| UniProt/SwissProt ID: | GROA_HUMAN |
| Description: | chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [Source:HGNC Symbol;Acc:4602] |
| Location: | chr4 q13.3 |
| Node attribute: | PPI(source); ligand; gene |
| Phosphorylation site |
| GROA_HUMAN do not have phosphorylation site. |
| Dephosphorylation site |
| GROA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| GROA_HUMAN do not have mutation site. |
| Differential expressed protein |
| GROA_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| GROA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GROA_HUMAN | DUFFY_HUMAN | ligand -> receptor | HPMR |
| GROA_HUMAN | CXCR2_HUMAN | ligand -> receptor | HPMR |
| GROA_HUMAN | CXCR2_HUMAN | other | KEGG |
| MK14_HUMAN | GROA_HUMAN | TF -> target gene | KEGG |
| JUN_HUMAN | GROA_HUMAN | TF -> target gene | KEGG |
| NFKB1_HUMAN | GROA_HUMAN | TF -> target gene | KEGG |
| SP1_HUMAN | GROA_HUMAN | TF -> target gene | TRANSFAC |
| SP3_HUMAN | GROA_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05134 | Legionellosis |
| hsa05323 | Rheumatoid arthritis |
| hsa05132 | Salmonella infection |
| hsa05120 | Epithelial cell signaling in Helicobacter pylori i |
| hsa04621 | NOD-like receptor signaling pathway |
| hsa04062 | Chemokine signaling pathway |
| hsa04060 | Cytokine-cytokine receptor interaction |
| hsa05146 | Amoebiasis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008009 | chemokine activity | IEA | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0006935 | chemotaxis | TAS | biological_process |
| GO:0008047 | enzyme activator activity | TAS | molecular_function |
| GO:0043085 | positive regulation of catalytic activity | TAS | biological_process |
| GO:0035556 | intracellular signal transduction | TAS | biological_process |
| GO:0008285 | negative regulation of cell proliferation | TAS | biological_process |
| GO:0006955 | immune response | IEA | biological_process |
| GO:0006954 | inflammatory response | IEA | biological_process |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0005615 | extracellular space | IEA | cellular_component |
| GO:0008283 | cell proliferation | TAS | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005102 | receptor binding | TAS | molecular_function |
| GO:0030036 | actin cytoskeleton organization | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |