Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:NOS3_HUMAN
Description:nitric oxide synthase 3 (endothelial cell) [Source:HGNC Symbol;Acc:7876]
Location:chr7 q36.1
Node attribute:PPI(target); substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1179RTQSFsLQERQPhosphoSitePlus
S615KIRFNsISCSDFlavodoxin_1PhosphoSitePlus
S738QRYRLsAQAEGPhosphoSitePlus
T854RLPPCtLRQALFAD_binding_1PhosphoSitePlus
S615KIRFNsISCSDAKT_groupRegPhos
Y657LGSRAyPHFCAFlavodoxin_1PhosphoSitePlus
S1177RIRTQsFSLQEAMPK_groupRegPhos
S615KIRFNsISCSDPKB_groupphosphoELM
S1177RIRTQsFSLQEPhosphoSitePlus; phosphoELM; RegPhos
S1177RIRTQsFSLQEAKT_groupRegPhos
S633RKRKEsSNTDSPKA_groupphosphoELM; RegPhos
S114LQGRPsPGPPAPhosphoSitePlus
Y81VGSITyDTLSAPhosphoSitePlus; HPRD; phosphoELM
S1177RIRTQsFSLQEAKT1HPRD; RegPhos
T495ITRKKtFKEVAPhosphoSitePlus; phosphoELM; RegPhos
S1179RTQSFsLQERQPKB_groupphosphoELM
T1175TSRIRtQSFSLPhosphoSitePlus; HPRD; RegPhos
T512ASLMGtVMAKRPhosphoSitePlus
S508VKISAsLMGTVPhosphoSitePlus
S633RKRKEsSNTDSFlavodoxin_1PhosphoSitePlus
S1179RTQSFsLQERQAKT_groupRegPhos
S102RRCLGsLVFPRPhosphoSitePlus
S1177RIRTQsFSLQEPKB_groupphosphoELM
S633RKRKEsSNTDSHPRD; RegPhos
Y210QEMFTyICNHINO_synthasePhosphoSitePlus

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S1177TSRIRTQsFSLQERQPPP2R5AHPRD
T495TGITRKKtFKEVANAPPP2R5AHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000297494R474CSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000297494R602QCOSMICIntestines Cancer16959974
ENSP00000297494G439RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000297494V567ATCGAOvarian Cancer21720365, 18772890
ENSP00000297494G345SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000297494R602QSjoblom2006Intestines Cancer16959974
ENSP00000297494R474CHPIColorectal Cancer16959974
ENSP00000297494C1009*COSMICSkin Cancer21984974
ENSP00000297494V567ACOSMICOvarian Cancer21720365
ENSP00000297494G439RTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000297494E342KCOSMICSkin Cancer21984974
ENSP00000297494E564KCOSMICMelanoma21499247
ENSP00000297494R602QHPIColorectal Cancer16959974

Differential expressed protein
NOS3_HUMAN is not differential expressed protein.

Hyperphosphorylation site
NOS3_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AAPK2_HUMANNOS3_HUMANkinase -> substrateRegPhos
AKT3_HUMANNOS3_HUMANkinase -> substrateKEGG
ZAGL2_HUMANNOS3_HUMANkinase -> substrateRegPhos
AKT1_HUMANNOS3_HUMANkinase -> substrateHPRD; RegPhos
2A5A_HUMANNOS3_HUMANphosphatase -> substrateHPRD
PLCG1_HUMANNOS3_HUMANotherKEGG
ELK1_HUMANNOS3_HUMANTF -> target geneTRANSFAC
MZF1_HUMANNOS3_HUMANTF -> target geneTRANSFAC
SP1_HUMANNOS3_HUMANTF -> target geneTRANSFAC
ERG_HUMANNOS3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04370VEGF signaling pathway
hsa00330Arginine and proline metabolism
hsa04020Calcium signaling pathway
hsa01100Metabolic pathways

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0046209nitric oxide metabolic processTASbiological_process
GO:0010181FMN bindingIEAmolecular_function
GO:0002028regulation of sodium ion transportIEAbiological_process
GO:0034618arginine bindingIDAmolecular_function
GO:0005506iron ion bindingIEAmolecular_function
GO:0007596blood coagulationTASbiological_process
GO:0050660flavin adenine dinucleotide bindingNASmolecular_function
GO:0000139Golgi membraneTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0050880regulation of blood vessel sizeISSbiological_process
GO:0043267negative regulation of potassium ion transportIEAbiological_process
GO:0034405response to fluid shear stressIEPbiological_process
GO:0045776negative regulation of blood pressureIBAbiological_process
GO:0050880regulation of blood vessel sizeIEAbiological_process
GO:0051346negative regulation of hydrolase activityIEAbiological_process
GO:0005516calmodulin bindingIEAmolecular_function
GO:0001974blood vessel remodelingIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0046870cadmium ion bindingNASmolecular_function
GO:0050660flavin adenine dinucleotide bindingIEAmolecular_function
GO:0008285negative regulation of cell proliferationISSbiological_process
GO:0009408response to heatNASbiological_process
GO:0007263nitric oxide mediated signal transductionIBAbiological_process
GO:0014806smooth muscle hyperplasiaISSbiological_process
GO:0034617tetrahydrobiopterin bindingIDAmolecular_function
GO:0020037heme bindingIDAmolecular_function
GO:0090382phagosome maturationTASbiological_process
GO:0045909positive regulation of vasodilationNASbiological_process
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0050999regulation of nitric-oxide synthase activityTASbiological_process
GO:0031284positive regulation of guanylate cyclase activityISSbiological_process
GO:0003057regulation of the force of heart contraction by chIEAbiological_process
GO:0008217regulation of blood pressureNASbiological_process
GO:0051926negative regulation of calcium ion transportIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0003958NADPH-hemoprotein reductase activityIBAmolecular_function
GO:0003785actin monomer bindingIPImolecular_function
GO:0006809nitric oxide biosynthetic processIEAbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0010181FMN bindingNASmolecular_function
GO:0014740negative regulation of muscle hyperplasiaIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0007005mitochondrion organizationISSbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005901caveolaIDAcellular_component
GO:0014806smooth muscle hyperplasiaIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0045766positive regulation of angiogenesisISSbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0043542endothelial cell migrationIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0051701interaction with hostTASbiological_process
GO:0020037heme bindingIEAmolecular_function
GO:0014740negative regulation of muscle hyperplasiaISSbiological_process
GO:0050661NADP bindingIEAmolecular_function
GO:0005634nucleusISScellular_component
GO:0030666endocytic vesicle membraneTAScellular_component
GO:0006527arginine catabolic processIDAbiological_process
GO:0045766positive regulation of angiogenesisIEAbiological_process
GO:0003100regulation of systemic arterial blood pressure by IMPbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0001542ovulation from ovarian follicleIEAbiological_process
GO:0001974blood vessel remodelingISSbiological_process
GO:0050661NADP bindingNASmolecular_function
GO:0030324lung developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0010544negative regulation of platelet activationNASbiological_process
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0006809nitric oxide biosynthetic processIDAbiological_process
GO:0004517nitric-oxide synthase activityIDAmolecular_function
GO:0004517nitric-oxide synthase activityIEAmolecular_function