| UniProt/SwissProt ID: | ITAM_HUMAN |
| Description: | integrin, alpha M (complement component 3 receptor 3 subunit) [Source:HGNC Symbol;Acc:6149] |
| Location: | chr16 p11.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y676 | QSVVTyDLALD | Integrin_alpha2 | PhosphoSitePlus |
| T930 | VYMVVtSHGVS | Integrin_alpha2 | PhosphoSitePlus |
| S1142 | YKDMMsEGGPP | Integrin_alpha | PhosphoSitePlus |
| S931 | YMVVTsHGVST | Integrin_alpha2 | PhosphoSitePlus |
| S574 | QRIAGsKLSPR | PhosphoSitePlus; HPRD | |
| T805 | FNVTVtVRNDG | Integrin_alpha2 | PhosphoSitePlus |
| S577 | AGSKLsPRLQY | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| ITAM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000287497 | K646N | COSMIC | Renal Cancer | 20054297 | ENSP00000287497 | N326D | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| ITAM_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ITAM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | ITAM_HUMAN | TF -> target gene | TRANSFAC |
| SPI1_HUMAN | ITAM_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ITAM_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009897 | external side of plasma membrane | IEA | cellular_component |
| GO:0030593 | neutrophil chemotaxis | IEA | biological_process |
| GO:0001948 | glycoprotein binding | IPI | molecular_function |
| GO:0007155 | cell adhesion | IEA | biological_process |
| GO:0043395 | heparan sulfate proteoglycan binding | IEA | molecular_function |
| GO:0008305 | integrin complex | IEA | cellular_component |
| GO:0007229 | integrin-mediated signaling pathway | IEA | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007155 | cell adhesion | TAS | biological_process |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0007159 | leukocyte cell-cell adhesion | IEA | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0001846 | opsonin binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0016337 | cell-cell adhesion | IEA | biological_process |
| GO:0050798 | activated T cell proliferation | IEA | biological_process |
| GO:0009986 | cell surface | IEA | cellular_component |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0014005 | microglia development | IEA | biological_process |
| GO:0045123 | cellular extravasation | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |