Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PSN1_HUMAN
Description:presenilin 1 [Source:HGNC Symbol;Acc:9508]
Location:chr14 q24.2
Node attribute:PPI(source); substrate; ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S324STEREsQDTVAPresenilinPhosphoSitePlus
S365AVQELsSSILAHPRD; phosphoELM; SysPTM
S319KYNAEsTERESPresenilinPhosphoSitePlus
S357RSTPEsRAAVQGSK3BHPRD; RegPhos
S346EAQRDsHLGPHPKC_groupRegPhos
S366VQELSsSILAGHPRD; phosphoELM
T354GPHRStPESRACDK5HPRD; phosphoELM; RegPhos; SysPTM
S353LGPHRsTPESRGSK3BHPRD; RegPhos
S102VATIKsVSFYTTM; PresenilinPhosphoSitePlus
S353LGPHRsTPESRGSK-3_betaphosphoELM
S55RPQGNsRQVVEHPRD
T354GPHRStPESRACDK_groupphosphoELM; RegPhos; SysPTM
T354GPHRStPESRAPresenilinPhosphoSitePlus; SysPTM
S310AQRRVsKNSKYPKACaRegPhos
S346EAQRDsHLGPHPresenilinPhosphoSitePlus
S366VQELSsSILAGPresenilinPhosphoSitePlus
S367QELSSsILAGEPresenilinPhosphoSitePlus; SysPTM
S357RSTPEsRAAVQGSK-3_betaphosphoELM
S310AQRRVsKNSKYPRKACAHPRD
S361AVQELsSSILAHPRD
T320YNAEStERESQPresenilinPhosphoSitePlus
S353LGPHRsTPESRPresenilinPhosphoSitePlus
S365AVQELsSSILAPresenilinPhosphoSitePlus; SysPTM
S353LGPHRsTPESRGSK3B(GSK3 betaRegPhos
S357RSTPEsRAAVQPresenilinPhosphoSitePlus
T350GPHRStPESRAHPRD
S346EAQRDsHLGPHPRKCZHPRD
S310AQRRVsKNSKYPKA_groupphosphoELM; RegPhos
S310AQRRVsKNSKYPresenilinPhosphoSitePlus
S51HPEPLsNGRPQPhosphoSitePlus; HPRD
S47HPEPLsNGRPQHPRD
S346EAQRDsHLGPHPKC_alphaphosphoELM
S39HNDRRsLGHPEHPRD
S367QELSSsILAGEHPRD; phosphoELM; RegPhos; SysPTM
S43HNDRRsLGHPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S362VQELSsSILAGHPRD
S363QELSSsILAGEHPRD
S346EAQRDsHLGPHPKCzRegPhos
Y154LLVVLyKYRCYPresenilinPhosphoSitePlus
S357RSTPEsRAAVQGSK3B(GSK3 betaRegPhos
S346EAQRDsHLGPHPKCa(PKC alphaRegPhos
S104TIKSVsFYTRKPresenilinPhosphoSitePlus
S59RPQGNsRQVVEHPRD

Dephosphorylation site
PSN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000326366E321*COSMICBreast Cancer20668451
ENSP00000326366Y315CCOSMICRenal Cancer21248752

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000326366Testicular CancerNormal vs. Cancercell lineDown18489135

Hyperphosphorylation site
PSN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PSN1_HUMANNICA_HUMANligand -> receptorHPMR
CDK5_HUMANPSN1_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANPSN1_HUMANkinase -> substrateRegPhos
KPCZ_HUMANPSN1_HUMANkinase -> substrateHPRD
KPCA_HUMANPSN1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
GSK3B_HUMANPSN1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PSN1_HUMANATF6A_HUMANotherKEGG
PSN1_HUMANE2AK3_HUMANotherKEGG
PSN1_HUMANERN1_HUMANotherKEGG
PSN1_HUMANCTNB1_HUMANotherKEGG
CREB1_HUMANPSN1_HUMANTF -> target geneTRANSFAC
ETS1_HUMANPSN1_HUMANTF -> target geneTRANSFAC
SP1_HUMANPSN1_HUMANTF -> target geneTRANSFAC
ETS2_HUMANPSN1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05010Alzheimer's disease
hsa04330Notch signaling pathway
hsa04310Wnt signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005794Golgi apparatusIDAcellular_component
GO:0043589skin morphogenesisIEAbiological_process
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0035253ciliary rootletIBAcellular_component
GO:0005743mitochondrial inner membraneIBAcellular_component
GO:2000059negative regulation of protein ubiquitination invoIEAbiological_process
GO:0007220Notch receptor processingIBAbiological_process
GO:0060075regulation of resting membrane potentialIEAbiological_process
GO:0032436positive regulation of proteasomal ubiquitin-depenIEAbiological_process
GO:0030424axonIEAcellular_component
GO:0007613memoryIEAbiological_process
GO:0030165PDZ domain bindingIPImolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0015031protein transportIEAbiological_process
GO:0005262calcium channel activityIMPmolecular_function
GO:0021904dorsal/ventral neural tube patterningIEAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0005790smooth endoplasmic reticulumIDAcellular_component
GO:0021870Cajal-Retzius cell differentiationIEAbiological_process
GO:0030425dendriteIEAcellular_component
GO:0009790embryo developmentIEAbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0042640anagenIEAbiological_process
GO:0043025neuronal cell bodyIBAcellular_component
GO:0051966regulation of synaptic transmission, glutamatergicIEAbiological_process
GO:0004175endopeptidase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0007420brain developmentIEAbiological_process
GO:0009986cell surfaceIEAcellular_component
GO:0007611learning or memoryIEAbiological_process
GO:0004190aspartic-type endopeptidase activityIEAmolecular_function
GO:0045121membrane raftIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0009986cell surfaceIBAcellular_component
GO:0016020membraneTAScellular_component
GO:0007219Notch signaling pathwayTASbiological_process
GO:0050673epithelial cell proliferationIEAbiological_process
GO:0005743mitochondrial inner membraneIEAcellular_component
GO:0005765lysosomal membraneIEAcellular_component
GO:0016080synaptic vesicle targetingIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0030424axonIBAcellular_component
GO:0043198dendritic shaftIEAcellular_component
GO:0045296cadherin bindingIBAmolecular_function
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0042325regulation of phosphorylationIDAbiological_process
GO:0000776kinetochoreIDAcellular_component
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0000045autophagic vacuole assemblyIEAbiological_process
GO:0030326embryonic limb morphogenesisIEAbiological_process
GO:0048854brain morphogenesisIEAbiological_process
GO:0031594neuromuscular junctionIEAcellular_component
GO:0022008neurogenesisIEAbiological_process
GO:0005783endoplasmic reticulumIDAcellular_component
GO:0045296cadherin bindingIEAmolecular_function
GO:0001933negative regulation of protein phosphorylationIEAbiological_process
GO:0002244hematopoietic progenitor cell differentiationIEAbiological_process
GO:0048538thymus developmentIEAbiological_process
GO:0001708cell fate specificationIEAbiological_process
GO:0007219Notch signaling pathwayIEAbiological_process
GO:0002573myeloid leukocyte differentiationIEAbiological_process
GO:0048471perinuclear region of cytoplasmIBAcellular_component
GO:0031594neuromuscular junctionIBAcellular_component
GO:0008013beta-catenin bindingIPImolecular_function
GO:0006839mitochondrial transportIEAbiological_process
GO:0006974response to DNA damage stimulusIEAbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0051563smooth endoplasmic reticulum calcium ion homeostasIBAbiological_process
GO:0007220Notch receptor processingIEAbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0016485protein processingIDAbiological_process
GO:0005640nuclear outer membraneIDAcellular_component
GO:0043085positive regulation of catalytic activityIDAbiological_process
GO:0009791post-embryonic developmentIEAbiological_process
GO:0031293membrane protein intracellular domain proteolysisTASbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0043227membrane-bounded organelleIEAcellular_component
GO:0045121membrane raftIBAcellular_component
GO:0031410cytoplasmic vesicleIEAcellular_component
GO:0051604protein maturationIEAbiological_process
GO:0004175endopeptidase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0048167regulation of synaptic plasticityIEAbiological_process
GO:0005938cell cortexIBAcellular_component
GO:0002286T cell activation involved in immune responseIEAbiological_process
GO:0001921positive regulation of receptor recyclingIEAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0006979response to oxidative stressIEAbiological_process
GO:0048666neuron developmentIEAbiological_process
GO:0040011locomotionIEAbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0031965nuclear membraneIDAcellular_component
GO:0001568blood vessel developmentIEAbiological_process
GO:0044267cellular protein metabolic processIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0006486protein glycosylationIEAbiological_process
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0016324apical plasma membraneIBAcellular_component
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0030426growth coneIBAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0015871choline transportIEAbiological_process
GO:0050852T cell receptor signaling pathwayIEAbiological_process
GO:0050820positive regulation of coagulationIEAbiological_process
GO:0050435beta-amyloid metabolic processIBAbiological_process
GO:0051402neuron apoptotic processIEAbiological_process
GO:0015813L-glutamate transportIEAbiological_process
GO:0005791rough endoplasmic reticulumIDAcellular_component
GO:0030426growth coneIEAcellular_component
GO:0005765lysosomal membraneIBAcellular_component
GO:0007175negative regulation of epidermal growth factor-actIEAbiological_process
GO:0043198dendritic shaftIBAcellular_component
GO:0001764neuron migrationIEAbiological_process
GO:0051444negative regulation of ubiquitin-protein ligase acIEAbiological_process
GO:0032469endoplasmic reticulum calcium ion homeostasisIEAbiological_process
GO:0042987amyloid precursor protein catabolic processIBAbiological_process
GO:0070588calcium ion transmembrane transportIMPbiological_process
GO:0035282segmentationIEAbiological_process
GO:0006914autophagyIEAbiological_process
GO:0043393regulation of protein bindingIEAbiological_process
GO:0070765gamma-secretase complexIDAcellular_component
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0035253ciliary rootletIEAcellular_component
GO:0007176regulation of epidermal growth factor-activated reIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0030018Z discIBAcellular_component
GO:0001934positive regulation of protein phosphorylationIEAbiological_process
GO:0050771negative regulation of axonogenesisIEAbiological_process
GO:0050435beta-amyloid metabolic processIEAbiological_process
GO:0043234protein complexIEAcellular_component
GO:0042987amyloid precursor protein catabolic processIEAbiological_process
GO:0032469endoplasmic reticulum calcium ion homeostasisIGIbiological_process
GO:0005813centrosomeIDAcellular_component
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0000186activation of MAPKK activityIEAbiological_process
GO:0006509membrane protein ectodomain proteolysisIDAbiological_process
GO:0051563smooth endoplasmic reticulum calcium ion homeostasIEAbiological_process
GO:0005739mitochondrionIDAcellular_component
GO:0001756somitogenesisIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0016337cell-cell adhesionIMPbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0021795cerebral cortex cell migrationIEAbiological_process
GO:0006816calcium ion transportIBAbiological_process