Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ACTC_HUMAN
Description:actin, alpha, cardiac muscle 1 [Source:HGNC Symbol;Acc:143]
Location:chr15 q14
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y190RDLTDyLMKILActinPhosphoSitePlus
Y364ISKQEyDEAGPActinPhosphoSitePlus
T91KIWHHtFYNELActinPhosphoSitePlus
T128QIMFEtFNVPAActinPhosphoSitePlus
S350GSILAsLSTFQActinPhosphoSitePlus
T188AGRDLtDYLMKActinPhosphoSitePlus
S35RAVFPsIVGRPActinPhosphoSitePlus
T196LMKILtERGYSActinPhosphoSitePlus
Y93WHHTFyNELRVActinPhosphoSitePlus
T280GIHETtYNSIMActinPhosphoSitePlus
S157GIVLDsGDGVTActinPhosphoSitePlus
S62GDEAQsKRGILActinPhosphoSitePlus
S283ETTYNsIMKCDActinPhosphoSitePlus
T251DGQVItIGNERActinPhosphoSitePlus
Y71ILTLKyPIEHGActinPhosphoSitePlus
Y55GQKDSyVGDEAActinPhosphoSitePlus
S241SSLEKsYELPDActinPhosphoSitePlus
Y200LTERGySFVTTActinPhosphoSitePlus
Y171PIYEGyALPHAActinPhosphoSitePlus
T68KRGILtLKYPIActinPhosphoSitePlus
T204GYSFVtTAEREActinPhosphoSitePlus
S54MGQKDsYVGDEActinPhosphoSitePlus
S325TALAPsTMKIKActinPhosphoSitePlus
Y296IRKDLyANNVLActinPhosphoSitePlus
Y242SLEKSyELPDGActinPhosphoSitePlus
Y168HNVPIyEGYALActinPhosphoSitePlus
T306LSGGTtMYPGIActinPhosphoSitePlus
Y281IHETTyNSIMKActinPhosphoSitePlus
T79EHGIItNWDDMActinPhosphoSitePlus
Y308GGTTMyPGIADActinPhosphoSitePlus
Y220KEKLCyVALDFActinPhosphoSitePlus
S201TERGYsFVTTAActinPhosphoSitePlus
S267TLFQPsFIGMEActinPhosphoSitePlus
T326ALAPStMKIKIActinPhosphoSitePlus
T320MQKEItALAPSActinPhosphoSitePlus
Y145AVLSLyASGRTActinPhosphoSitePlus

Dephosphorylation site
ACTC_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000290378D365NCOSMICSkin Cancer21984974
ENSP00000290378D246NCOSMICHead and Neck Cancer21798897
ENSP00000290378E102VCOSMICSkin Cancer21984974
ENSP00000290378S241GCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000290378Pancreatic CancerNormal vs. CancertissueUp3.816230073

Hyperphosphorylation site
ACTC_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SRF_HUMANACTC_HUMANTF -> target geneTRANSFAC
SP1_HUMANACTC_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
ACTC_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031032actomyosin structure organizationIEAbiological_process
GO:0017022myosin bindingIPImolecular_function
GO:0033275actin-myosin filament slidingIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030240skeletal muscle thin filament assemblyIEAbiological_process
GO:0060047heart contractionIMPbiological_process
GO:0055003cardiac myofibril assemblyISSbiological_process
GO:0005884actin filamentIDAcellular_component
GO:0055008cardiac muscle tissue morphogenesisISSbiological_process
GO:0070062extracellular vesicular exosomeIDAcellular_component
GO:0060048cardiac muscle contractionIEAbiological_process
GO:0006915apoptotic processISSbiological_process
GO:0030049muscle filament slidingTASbiological_process
GO:0031032actomyosin structure organizationISSbiological_process
GO:0031674I bandISScellular_component
GO:0042493response to drugIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0030017sarcomereIDAcellular_component
GO:0031674I bandIEAcellular_component
GO:0016887ATPase activityIDAmolecular_function
GO:0055003cardiac myofibril assemblyIEAbiological_process
GO:0006200ATP catabolic processIDAbiological_process
GO:0030240skeletal muscle thin filament assemblyISSbiological_process
GO:0030048actin filament-based movementIDAbiological_process
GO:0055008cardiac muscle tissue morphogenesisIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0042643actomyosin, actin partIDAcellular_component
GO:0005524ATP bindingIDAmolecular_function
GO:0006915apoptotic processIEAbiological_process


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