| UniProt/SwissProt ID: | CO4A2_HUMAN |
| Description: | collagen, type IV, alpha 2 [Source:HGNC Symbol;Acc:2203] |
| Location: | chr13 q34 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S1687 | QSFQGsPSADT | C4 | PhosphoSitePlus |
| T1204 | HGLPGtKGFPG | Collagen | PhosphoSitePlus |
| S1446 | GRGGVsAVPGF | PhosphoSitePlus | |
| Y306 | PGLRGyPGLSG | Collagen | PhosphoSitePlus |
| S321 | PGQKGsRGLDG | Collagen | PhosphoSitePlus |
| T1403 | AVQPGtVGPQG | HPRD | |
| Y327 | RGLDGyQGPDG | Collagen | PhosphoSitePlus |
| T1403 | AVQPGtVGPQG | Collagen | PhosphoSitePlus |
| Y1586 | DEIKPyISRCS | HPRD | |
| S1683 | TIPEQsFQGSP | C4 | PhosphoSitePlus |
| Dephosphorylation site |
| CO4A2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000353654 | P468S | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000353654 | E1083D | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353654 | G457E | COSMIC | Skin Cancer | 21984974 | ENSP00000353654 | V1138M | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000353654 | P307L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000353654 | P164S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000353654 | P164S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000353654 | G1119E | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000353654 | R1431C | COSMIC | Melanoma | 21499247 | ENSP00000353654 | R304K | COSMIC | Central Nervous System Neoplasms | 18772396 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000353654 | Breast Cancer | Normal vs. Cancer | tissue | Up | 18257521 | ENSP00000353654 | Breast Cancer | Normal vs. Cancer | cell line | Up | 3.2 | 19053080 | ENSP00000353654 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 |
| Hyperphosphorylation site |
| CO4A2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | CO4A2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CO4A2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0030198 | extracellular matrix organization | NAS | biological_process |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005201 | extracellular matrix structural constituent | TAS | molecular_function |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005581 | collagen | IEA | cellular_component |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0071560 | cellular response to transforming growth factor be | IEA | biological_process |
| GO:0005587 | collagen type IV | IEA | cellular_component |
| GO:0016525 | negative regulation of angiogenesis | IDA | biological_process |
| GO:0005788 | endoplasmic reticulum lumen | TAS | cellular_component |