Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TCAM1_HUMAN
Description:toll-like receptor adaptor molecule 1 [Source:HGNC Symbol;Acc:18348]
Location:chr19 p13.3
Node attribute:PPI(target); PPI(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y573AAYSAyLQSYLPhosphoSitePlus
S212LEISQsPTMPFPhosphoSitePlus; HPRD
Y570ALNAAySAYLQPhosphoSitePlus
S388PSSLEsSSEQKPhosphoSitePlus
S390SLESSsEQKFYTIRPhosphoSitePlus
S389SSLESsSEQKFPhosphoSitePlus
S500SPAQLsSDTASPhosphoSitePlus
S196GCSLRsTGSPAHPRD
Y577AYLQSyLSYQAPhosphoSitePlus
S199LRSTGsPASLAHPRD

Dephosphorylation site
TCAM1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000248244S327FCOSMICSkin Cancer21984974
ENSP00000248244M46ISjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000248244F528LCOSMICSkin Cancer21984974
ENSP00000248244G675EBIOMARTBreast Cancer21930507, 21930502
ENSP00000248244Q612KCOSMICSkin Cancer21984974

Differential expressed protein
TCAM1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TCAM1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TCAM1_HUMANTRAF3_HUMANotherKEGG
TLR3_HUMANTCAM1_HUMANotherKEGG
TCAM2_HUMANTCAM1_HUMANotherKEGG
SP1_HUMANTCAM1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05133Pertussis
hsa04620Toll-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04064NF-kappa B signaling pathway
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05160Hepatitis C

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050871positive regulation of B cell activationIEAbiological_process
GO:0031398positive regulation of protein ubiquitinationIEAbiological_process
GO:0032481positive regulation of type I interferon productioIEAbiological_process
GO:0051607defense response to virusIEAbiological_process
GO:0004871signal transducer activityIMPmolecular_function
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0007249I-kappaB kinase/NF-kappaB cascadeTASbiological_process
GO:0034138toll-like receptor 3 signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patTASbiological_process
GO:0032755positive regulation of interleukin-6 productionIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0045080positive regulation of chemokine biosynthetic procIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0045359positive regulation of interferon-beta biosynthetiIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0043496regulation of protein homodimerization activityIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035666TRIF-dependent toll-like receptor signaling pathwaTASbiological_process
GO:0032760positive regulation of tumor necrosis factor produIEAbiological_process
GO:0034142toll-like receptor 4 signaling pathwayTASbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0030890positive regulation of B cell proliferationIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0010008endosome membraneTAScellular_component
GO:0032092positive regulation of protein bindingIEAbiological_process
GO:0043330response to exogenous dsRNAIEAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0045429positive regulation of nitric oxide biosynthetic pIEAbiological_process
GO:0008063Toll signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling patIEAbiological_process
GO:0002281macrophage activation involved in immune responseIEAbiological_process