Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOMA_HUMAN
Description:growth hormone 1 [Source:HGNC Symbol;Acc:4261]
Location:chr17 q23.3
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T93SNREEtQQKSNHormone_1PhosphoSitePlus
S176KFDTNsHNDDAHormone_1PhosphoSitePlus
Y68PKEQKySFLQNHormone_1PhosphoSitePlus
S132LVYGAsDSNVYHPRD; phosphoELM
S176KFDTNsHNDDAHPRD; phosphoELM
S132LVYGAsDSNVYHormone_1PhosphoSitePlus
S97ETQQKsNLELLHormone_1PhosphoSitePlus
S161KFDTNsHNDDAHPRD
S77QNPQTsLCFSEHormone_1PhosphoSitePlus
S117LVYGAsDSNVYHPRD
S77QNPQTsLCFSEphosphoELM

Dephosphorylation site
SOMA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000408486*203LCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
SOMA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOMA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SOMA_HUMANGHR_HUMANligand -> receptorHPMR
SOMA_HUMANGHR_HUMANotherKEGG
SP1_HUMANSOMA_HUMANTF -> target geneTRANSFAC
PIT1_HUMANSOMA_HUMANTF -> target geneTRANSFAC
VDR_HUMANSOMA_HUMANTF -> target geneTRANSFAC
AP2A_HUMANSOMA_HUMANTF -> target geneTRANSFAC
NFIC_HUMANSOMA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005131growth hormone receptor bindingIPImolecular_function
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0005148prolactin receptor bindingIPImolecular_function
GO:0032355response to estradiol stimulusIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0060396growth hormone receptor signaling pathwayIDAbiological_process
GO:0070977bone maturationIDAbiological_process
GO:0015758glucose transportIDAbiological_process
GO:0046427positive regulation of JAK-STAT cascadeIDAbiological_process
GO:0043568positive regulation of insulin-like growth factor IDAbiological_process
GO:0060397JAK-STAT cascade involved in growth hormone signalTASbiological_process
GO:0007259JAK-STAT cascadeIDAbiological_process
GO:0040018positive regulation of multicellular organism growIDAbiological_process
GO:0042523positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0042517positive regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0043406positive regulation of MAP kinase activityTASbiological_process
GO:0010535positive regulation of activation of JAK2 kinase aIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0005179hormone activityIEAmolecular_function
GO:0005615extracellular spaceIDAcellular_component
GO:0008083growth factor activityIPImolecular_function


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