Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CCL2_HUMAN
Description:chemokine (C-C motif) ligand 2 [Source:HGNC Symbol;Acc:10618]
Location:chr17 q12
Node attribute:PPI(source); ligand; gene

Phosphorylation site
CCL2_HUMAN do not have phosphorylation site.

Dephosphorylation site
CCL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225831K58*COSMICHead and Neck Cancer21798893
ENSP00000225831R53*COSMICPancreatic Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000225831Pancreatic CancerNormal vs. CancertissueUp2016215274
ENSP00000225831Gastric CancerNormal vs. Cancercell lineDown0.0220812763
ENSP00000225831Gastric CancerNormal vs. Cancercell lineDown0.0820812763

Hyperphosphorylation site
CCL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CCL2_HUMANCCR1_HUMANligand -> receptorHPMR
CCL2_HUMANCCR2_HUMANligand -> receptorHPMR
CCL2_HUMANNOCT_HUMANligand -> receptorHPMR
CCL2_HUMANCCR2_HUMANotherKEGG
TF65_HUMANCCL2_HUMANTF -> target geneTRANSFAC
STAT1_HUMANCCL2_HUMANTF -> target geneTRANSFAC
SP1_HUMANCCL2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05144Malaria
hsa05142Chagas disease (American trypanosomiasis)
hsa05168Herpes simplex infection
hsa04060Cytokine-cytokine receptor interaction
hsa05323Rheumatoid arthritis
hsa04621NOD-like receptor signaling pathway
hsa04062Chemokine signaling pathway
hsa05164Influenza A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:2000427positive regulation of apoptotic cell clearanceIEAbiological_process
GO:0043025neuronal cell bodyIEAcellular_component
GO:0004672protein kinase activityTASmolecular_function
GO:0090265positive regulation of immune complex clearance byIEAbiological_process
GO:0019725cellular homeostasisTASbiological_process
GO:0031100organ regenerationIEAbiological_process
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0051770positive regulation of nitric-oxide synthase biosyIEAbiological_process
GO:0001525angiogenesisTASbiological_process
GO:0046677response to antibioticIEAbiological_process
GO:0050870positive regulation of T cell activationISSbiological_process
GO:0071356cellular response to tumor necrosis factorISSbiological_process
GO:0006954inflammatory responseIDAbiological_process
GO:0031663lipopolysaccharide-mediated signaling pathwayIDAbiological_process
GO:0048246macrophage chemotaxisIDAbiological_process
GO:0007010cytoskeleton organizationIDAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0071347cellular response to interleukin-1IEAbiological_process
GO:0071222cellular response to lipopolysaccharideIEAbiological_process
GO:0048246macrophage chemotaxisIEAbiological_process
GO:0009408response to heatIEAbiological_process
GO:0031727CCR2 chemokine receptor bindingIEAmolecular_function
GO:0071356cellular response to tumor necrosis factorIEAbiological_process
GO:0051770positive regulation of nitric-oxide synthase biosyISSbiological_process
GO:0006987activation of signaling protein activity involved TASbiological_process
GO:0071222cellular response to lipopolysaccharideISSbiological_process
GO:0030593neutrophil chemotaxisIEAbiological_process
GO:0008360regulation of cell shapeIDAbiological_process
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0007568agingIEAbiological_process
GO:0043491protein kinase B signaling cascadeIMPbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0071347cellular response to interleukin-1ISSbiological_process
GO:0001664G-protein coupled receptor bindingIEAmolecular_function
GO:0050806positive regulation of synaptic transmissionIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0030968endoplasmic reticulum unfolded protein responseTASbiological_process
GO:0044344cellular response to fibroblast growth factor stimIEPbiological_process
GO:0006874cellular calcium ion homeostasisIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0007259JAK-STAT cascadeTASbiological_process
GO:0043615astrocyte cell migrationIDAbiological_process
GO:0010574regulation of vascular endothelial growth factor pIEAbiological_process
GO:0000165MAPK cascadeIMPbiological_process
GO:0002548monocyte chemotaxisIDAbiological_process
GO:0035684helper T cell extravasationIEAbiological_process
GO:0007155cell adhesionTASbiological_process
GO:0006955immune responseIEAbiological_process
GO:0005102receptor bindingTASmolecular_function
GO:0045471response to ethanolIEAbiological_process
GO:2000427positive regulation of apoptotic cell clearanceISSbiological_process
GO:0033552response to vitamin B3IEAbiological_process
GO:0048247lymphocyte chemotaxisIEAbiological_process
GO:0006959humoral immune responseTASbiological_process
GO:2000502negative regulation of natural killer cell chemotaIDAbiological_process
GO:0006935chemotaxisTASbiological_process
GO:0008201heparin bindingIEAmolecular_function
GO:0014823response to activityIEAbiological_process
GO:0006954inflammatory responseIEAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0050870positive regulation of T cell activationIEAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0031727CCR2 chemokine receptor bindingISSmolecular_function
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0071346cellular response to interferon-gammaIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0009611response to woundingIEAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0035684helper T cell extravasationISSbiological_process
GO:0009617response to bacteriumIEPbiological_process
GO:0019221cytokine-mediated signaling pathwayIDAbiological_process
GO:0009887organ morphogenesisTASbiological_process
GO:0070098chemokine-mediated signaling pathwayIEAbiological_process
GO:0019079viral genome replicationTASbiological_process
GO:0071346cellular response to interferon-gammaISSbiological_process
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0060137maternal process involved in parturitionIEAbiological_process
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0010759positive regulation of macrophage chemotaxisIEAbiological_process
GO:0071407cellular response to organic cyclic compoundIDAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0043066negative regulation of apoptotic processIDAbiological_process
GO:0010332response to gamma radiationIEAbiological_process
GO:0016525negative regulation of angiogenesisIEAbiological_process
GO:0005576extracellular regionIDAcellular_component
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0008009chemokine activityIEAmolecular_function
GO:0032496response to lipopolysaccharideIEAbiological_process