Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PAI2_HUMAN
Description:serpin peptidase inhibitor, clade B (ovalbumin), member 2 [Source:HGNC Symbol;Acc:8584]
Location:chr18 q21.33
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T72AVTPMtPENFTSerpinPhosphoSitePlus
S296LNKWTsKDKMASerpinPhosphoSitePlus
T69GANAVtPMTPESerpinPhosphoSitePlus

Dephosphorylation site
PAI2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000299502N127SCOSMICHepatocellular Carcinoma21822264
ENSP00000401645N127SCOSMICHepatocellular Carcinoma21822264
ENSP00000401645E285KCOSMICLung Cancer
ENSP00000299502E285KCOSMICLung Cancer

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000401645Pancreatic CancerNormal vs. CancertissueDown0.0516215274
ENSP00000401645Breast CancerNormal vs. Cancercell lineDown0.2220198662

Hyperphosphorylation site
PAI2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANPAI2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PAI2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042060wound healingIEAbiological_process
GO:0010951negative regulation of endopeptidase activityIBAbiological_process
GO:0005615extracellular spaceIEAcellular_component
GO:0030162regulation of proteolysisIBAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043066negative regulation of apoptotic processTASbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIEAmolecular_function
GO:0042730fibrinolysisTASbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005576extracellular regionTAScellular_component


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