| UniProt/SwissProt ID: | TTF1_HUMAN |
| Description: | transcription termination factor, RNA polymerase I [Source:HGNC Symbol;Acc:12397] |
| Location: | chr9 q34.13 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y476 | DSEIRyLSADS | PhosphoSitePlus; HPRD | |
| Y868 | RDIFYyEDDSE | PhosphoSitePlus | |
| S297 | AMPEGsQVGSE | PhosphoSitePlus | |
| S253 | TDMQEsQPTVG | PhosphoSitePlus | |
| S47 | LVNEQsQITRR | HPRD | |
| S227 | KKKKSsNREYE | PhosphoSitePlus | |
| S481 | YLSADsGDADD | PhosphoSitePlus; HPRD; phosphoELM | |
| S15 | IHTPVsDKKKK | PhosphoSitePlus; HPRD | |
| S240 | AMPEGsQAGRE | PhosphoSitePlus; HPRD; phosphoELM | |
| T12 | RFEIHtPVSDK | PhosphoSitePlus; HPRD | |
| S41 | IFRDSsLVNEQ | HPRD | |
| S872 | YYEDDsEGEDI | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S487 | GDADDsDADLG | PhosphoSitePlus; HPRD; phosphoELM | |
| S478 | EIRYLsADSGD | PhosphoSitePlus; HPRD; phosphoELM | |
| S403 | KRARVsGDDFS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S361 | AYPEGsQVGSE | PhosphoSitePlus | |
| S301 | GSQVGsEVGAD | PhosphoSitePlus | |
| S64 | FQHLIsSPLKK | HPRD; phosphoELM | |
| S65 | QHLISsPLKKS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S365 | GSQVGsEVGTV | PhosphoSitePlus | |
| T82 | ANATStLKKRK | PhosphoSitePlus | |
| Y231 | SSNREyETLAM | PhosphoSitePlus; HPRD; phosphoELM | |
| S161 | SEALHsKVREK | PhosphoSitePlus | |
| Dephosphorylation site |
| TTF1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000333920 | D519Y | COSMIC | Pancreatic Cancer | ENSP00000333920 | K747N | COSMIC | Ovarian Cancer | 21720365 | ENSP00000333920 | S240W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000333920 | A176V | COSMIC | Head and Neck Cancer | 21798897 |
| Differential expressed protein |
| TTF1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TTF1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP3_HUMAN | TTF1_HUMAN | TF -> target gene | TRANSFAC |
| SP1_HUMAN | TTF1_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| TTF1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0008156 | negative regulation of DNA replication | IEA | biological_process |
| GO:0006363 | termination of RNA polymerase I transcription | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0006360 | transcription from RNA polymerase I promoter | TAS | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006363 | termination of RNA polymerase I transcription | IEA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0006338 | chromatin remodeling | IEA | biological_process |
| GO:0006361 | transcription initiation from RNA polymerase I pro | IEA | biological_process |
| GO:0006353 | DNA-dependent transcription, termination | NAS | biological_process |
| GO:0003682 | chromatin binding | IEA | molecular_function |
| GO:0005634 | nucleus | NAS | cellular_component |