Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TTF1_HUMAN
Description:transcription termination factor, RNA polymerase I [Source:HGNC Symbol;Acc:12397]
Location:chr9 q34.13
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y476DSEIRyLSADSPhosphoSitePlus; HPRD
Y868RDIFYyEDDSEPhosphoSitePlus
S297AMPEGsQVGSEPhosphoSitePlus
S253TDMQEsQPTVGPhosphoSitePlus
S47LVNEQsQITRRHPRD
S227KKKKSsNREYEPhosphoSitePlus
S481YLSADsGDADDPhosphoSitePlus; HPRD; phosphoELM
S15IHTPVsDKKKKPhosphoSitePlus; HPRD
S240AMPEGsQAGREPhosphoSitePlus; HPRD; phosphoELM
T12RFEIHtPVSDKPhosphoSitePlus; HPRD
S41IFRDSsLVNEQHPRD
S872YYEDDsEGEDIPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S487GDADDsDADLGPhosphoSitePlus; HPRD; phosphoELM
S478EIRYLsADSGDPhosphoSitePlus; HPRD; phosphoELM
S403KRARVsGDDFSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S361AYPEGsQVGSEPhosphoSitePlus
S301GSQVGsEVGADPhosphoSitePlus
S64FQHLIsSPLKKHPRD; phosphoELM
S65QHLISsPLKKSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S365GSQVGsEVGTVPhosphoSitePlus
T82ANATStLKKRKPhosphoSitePlus
Y231SSNREyETLAMPhosphoSitePlus; HPRD; phosphoELM
S161SEALHsKVREKPhosphoSitePlus

Dephosphorylation site
TTF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000333920D519YCOSMICPancreatic Cancer
ENSP00000333920K747NCOSMICOvarian Cancer21720365
ENSP00000333920S240WCOSMICOvarian Cancer21720365
ENSP00000333920A176VCOSMICHead and Neck Cancer21798897

Differential expressed protein
TTF1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TTF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP3_HUMANTTF1_HUMANTF -> target geneTRANSFAC
SP1_HUMANTTF1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
TTF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005730nucleolusIEAcellular_component
GO:0008156negative regulation of DNA replicationIEAbiological_process
GO:0006363termination of RNA polymerase I transcriptionTASbiological_process
GO:0010467gene expressionTASbiological_process
GO:0006360transcription from RNA polymerase I promoterTASbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006363termination of RNA polymerase I transcriptionIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0006338chromatin remodelingIEAbiological_process
GO:0006361transcription initiation from RNA polymerase I proIEAbiological_process
GO:0006353DNA-dependent transcription, terminationNASbiological_process
GO:0003682chromatin bindingIEAmolecular_function
GO:0005634nucleusNAScellular_component


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