| UniProt/SwissProt ID: | KC1A_HUMAN |
| Description: | casein kinase 1, alpha 1 [Source:HGNC Symbol;Acc:2451] |
| Location: | chr5 q32 |
| Node attribute: | kinase; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S341 | QAASSsGQGQQ | HPRD | |
| S3 | ___MAsSSGSK | PhosphoSitePlus | |
| T351 | QAQTPtGKQTD | HPRD | |
| T184 | KNLTGtARYAS | Pkinase | PhosphoSitePlus |
| S218 | YFNRTsLPWQG | Pkinase | PhosphoSitePlus |
| S311 | AQQAAsSSGQG | PhosphoSitePlus; HPRD | |
| Y17 | IVGGKyKLVRK | Pkinase | PhosphoSitePlus |
| Y85 | GQEKDyNVLVM | Pkinase | PhosphoSitePlus |
| S156 | NKCLEsPVGKR | HPRD | |
| Y294 | NHQYDyTFDWT | PhosphoSitePlus | |
| S340 | QQAASsSGQGQ | HPRD | |
| S339 | AQQAAsSSGQG | HPRD | |
| T287 | RILFRtLNHQY | Pkinase | PhosphoSitePlus |
| T349 | GQQAQtPTGKQ | HPRD | |
| S312 | QQAASsSGQGQ | HPRD | |
| T321 | GQQAQtPTGKQ | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S313 | QAASSsGQGQQ | HPRD | |
| Y59 | HPQLLyESKLY | Pkinase | PhosphoSitePlus |
| S332 | TDKTKsNMKGF | PhosphoSitePlus | |
| T327 | PTGKQtDKTKS | PhosphoSitePlus; HPRD | |
| S3 | SGSK | HPRD | |
| S199 | LGIEQsRRDDM | Pkinase | PhosphoSitePlus |
| S105 | LFNFCsRRFTM | Pkinase | PhosphoSitePlus |
| Y32 | SFGDIyLAINI | Pkinase | PhosphoSitePlus |
| Y292 | TLNHQyDYTFD | Pkinase | PhosphoSitePlus |
| S242 | SEKKMsTPVEV | Pkinase | PhosphoSitePlus |
| T323 | QAQTPtGKQTD | HPRD | |
| T355 | PTGKQtDKTKS | HPRD | |
| Dephosphorylation site |
| KC1A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000367074 | D297H | HPI | Breast Cancer | 17344846 | ENSP00000421689 | M165I | COSMIC | Lung Cancer | 20668451 | ENSP00000421689 | E274* | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000367074 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000367074 | Gastric Cancer | Normal vs. Cancer | tissue | Up | 2.8 | 15761955 |
| Hyperphosphorylation site |
| KC1A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KC1A_HUMAN | MDM4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | BID_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | LEG3_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KC1A_HUMAN | FOXO1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | B3AT_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | PRKN2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | MDM2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | PLMN_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | SYUA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | NFAC3_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | P53_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | 1433Z_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KC1A_HUMAN | 1433T_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KC1A_HUMAN | SRC8_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | CREM_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | BACE1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | HNRPC_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| KC1A_HUMAN | ASAP3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | GNA12_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | VMAT2_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | CSEN_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KC1A_HUMAN | CTNB1_HUMAN | kinase -> substrate | HPRD; NetPath |
| KC1A_HUMAN | FADD_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | PSN2_HUMAN | kinase -> substrate | HPRD |
| KC1A_HUMAN | EI2BE_HUMAN | kinase -> substrate | HPRD |
| SP1_HUMAN | KC1A_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04340 | Hedgehog signaling pathway |
| hsa04310 | Wnt signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004672 | protein kinase activity | TAS | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0005847 | mRNA cleavage and polyadenylation specificity fact | IDA | cellular_component |
| GO:0004674 | protein serine/threonine kinase activity | IDA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0007067 | mitosis | IEA | biological_process |
| GO:0016607 | nuclear speck | IDA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0016055 | Wnt receptor signaling pathway | IEA | biological_process |
| GO:0051301 | cell division | IEA | biological_process |
| GO:0007166 | cell surface receptor signaling pathway | TAS | biological_process |
| GO:0000777 | condensed chromosome kinetochore | IEA | cellular_component |