Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KC1A_HUMAN
Description:casein kinase 1, alpha 1 [Source:HGNC Symbol;Acc:2451]
Location:chr5 q32
Node attribute:kinase; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S341QAASSsGQGQQHPRD
S3___MAsSSGSKPhosphoSitePlus
T351QAQTPtGKQTDHPRD
T184KNLTGtARYASPkinasePhosphoSitePlus
S218YFNRTsLPWQGPkinasePhosphoSitePlus
S311AQQAAsSSGQGPhosphoSitePlus; HPRD
Y17IVGGKyKLVRKPkinasePhosphoSitePlus
Y85GQEKDyNVLVMPkinasePhosphoSitePlus
S156NKCLEsPVGKRHPRD
Y294NHQYDyTFDWTPhosphoSitePlus
S340QQAASsSGQGQHPRD
S339AQQAAsSSGQGHPRD
T287RILFRtLNHQYPkinasePhosphoSitePlus
T349GQQAQtPTGKQHPRD
S312QQAASsSGQGQHPRD
T321GQQAQtPTGKQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S313QAASSsGQGQQHPRD
Y59HPQLLyESKLYPkinasePhosphoSitePlus
S332TDKTKsNMKGFPhosphoSitePlus
T327PTGKQtDKTKSPhosphoSitePlus; HPRD
S3SGSKHPRD
S199LGIEQsRRDDMPkinasePhosphoSitePlus
S105LFNFCsRRFTMPkinasePhosphoSitePlus
Y32SFGDIyLAINIPkinasePhosphoSitePlus
Y292TLNHQyDYTFDPkinasePhosphoSitePlus
S242SEKKMsTPVEVPkinasePhosphoSitePlus
T323QAQTPtGKQTDHPRD
T355PTGKQtDKTKSHPRD

Dephosphorylation site
KC1A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000367074D297HHPIBreast Cancer17344846
ENSP00000421689M165ICOSMICLung Cancer20668451
ENSP00000421689E274*COSMICLung Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000367074Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000367074Gastric CancerNormal vs. CancertissueUp2.815761955

Hyperphosphorylation site
KC1A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KC1A_HUMANMDM4_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANBID_HUMANkinase -> substrateHPRD
KC1A_HUMANLEG3_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1A_HUMANFOXO1_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANB3AT_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANPRKN2_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANPLMN_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANSYUA_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANNFAC3_HUMANkinase -> substrateHPRD
KC1A_HUMANP53_HUMANkinase -> substrateHPRD
KC1A_HUMAN1433Z_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1A_HUMAN1433T_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1A_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANCREM_HUMANkinase -> substrateHPRD
KC1A_HUMANBACE1_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANHNRPC_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KC1A_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANGNA12_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANVMAT2_HUMANkinase -> substrateHPRD
KC1A_HUMANCSEN_HUMANkinase -> substrateRobert H Newman (2013)
KC1A_HUMANCTNB1_HUMANkinase -> substrateHPRD; NetPath
KC1A_HUMANFADD_HUMANkinase -> substrateHPRD
KC1A_HUMANPSN2_HUMANkinase -> substrateHPRD
KC1A_HUMANEI2BE_HUMANkinase -> substrateHPRD
SP1_HUMANKC1A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04340Hedgehog signaling pathway
hsa04310Wnt signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004672protein kinase activityTASmolecular_function
GO:0006468protein phosphorylationIDAbiological_process
GO:0005847mRNA cleavage and polyadenylation specificity factIDAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0005813centrosomeIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0007165signal transductionNASbiological_process
GO:0007067mitosisIEAbiological_process
GO:0016607nuclear speckIDAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0016055Wnt receptor signaling pathwayIEAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0007166cell surface receptor signaling pathwayTASbiological_process
GO:0000777condensed chromosome kinetochoreIEAcellular_component


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