| UniProt/SwissProt ID: | RL10_HUMAN |
| Description: | ribosomal protein L10 [Source:HGNC Symbol;Acc:10298] |
| Location: | chrX q28 |
| Node attribute: | substrate; kinase; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S168 | QKIHIsKKWGF | RPL10(P27635 | RegPhos |
| S168 | QKIHIsKKWGF | PKCa | RegPhos |
| S137 | GQVIMsIRTKL | PRKCA | HPRD |
| S61 | EYEQLsSEALE | Ribosomal_L16 | PhosphoSitePlus |
| S168 | QKIHIsKKWGF | PRKCA | HPRD |
| S104 | INKMLsCAGAD | Ribosomal_L16 | PhosphoSitePlus |
| Y57 | MVSDEyEQLSS | Ribosomal_L16 | PhosphoSitePlus |
| Y9 | RPARCyRYCKN | HPRD | |
| Y17 | CKNKPyPKSRF | Ribosomal_L16 | PhosphoSitePlus |
| S137 | GQVIMsIRTKL | PKCa | RegPhos |
| S137 | GQVIMsIRTKL | RPL10(P27635 | RegPhos |
| Y75 | ICANKyMVKSC | Ribosomal_L16 | PhosphoSitePlus |
| Y9 | RPARCyRYCKN | Ribosomal_L16 | PhosphoSitePlus |
| S54 | CGHMVsDEYEQ | Ribosomal_L16 | PhosphoSitePlus |
| Dephosphorylation site |
| RL10_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000341730 | R90W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000413436 | M184L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000413436 | R90W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000358832 | M184L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000358832 | R90W | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000341730 | M184L | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000413436 | Non-small cell lung carcinoma | Treatment (none vs CIGB-300 treatment) | cell line | Up | 2.7 | 20804217 |
| Hyperphosphorylation site |
| RL10_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RL10_HUMAN | RL10_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | RL10_HUMAN | kinase -> substrate | HPRD |
| SP1_HUMAN | RL10_HUMAN | TF -> target gene | TRANSFAC |
| CREB1_HUMAN | RL10_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03010 | Ribosome |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0022625 | cytosolic large ribosomal subunit | IDA | cellular_component |
| GO:0019058 | viral infectious cycle | TAS | biological_process |
| GO:0019083 | viral transcription | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005840 | ribosome | IEA | cellular_component |
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsen | TAS | biological_process |
| GO:0003735 | structural constituent of ribosome | IEA | molecular_function |
| GO:0006614 | SRP-dependent cotranslational protein targeting to | TAS | biological_process |
| GO:0006413 | translational initiation | TAS | biological_process |
| GO:0006415 | translational termination | TAS | biological_process |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0016071 | mRNA metabolic process | TAS | biological_process |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0044267 | cellular protein metabolic process | TAS | biological_process |
| GO:0006412 | translation | IEA | biological_process |
| GO:0006414 | translational elongation | TAS | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016032 | viral reproduction | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0003735 | structural constituent of ribosome | NAS | molecular_function |
| GO:0006412 | translation | NAS | biological_process |