| UniProt/SwissProt ID: | ASSY_HUMAN |
| Description: | argininosuccinate synthase 1 [Source:HGNC Symbol;Acc:758] |
| Location: | chr9 q34.11 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y87 | LYEDRyLLGTS | HPRD | |
| S352 | GKVQVsVLKGQ | Arginosuc_synth | PhosphoSitePlus |
| S131 | VRFELsCYSLA | Arginosuc_synth | PhosphoSitePlus |
| Y163 | NDLMEyAKQHG | Arginosuc_synth | PhosphoSitePlus |
| S92 | YLLGTsLARPC | Arginosuc_synth | PhosphoSitePlus |
| Y383 | NVQGDyEPTDA | Arginosuc_synth | PhosphoSitePlus |
| T174 | IPIPVtPKNPW | Arginosuc_synth | PhosphoSitePlus |
| S180 | PKNPWsMDENL | Arginosuc_synth | PhosphoSitePlus |
| T219 | AKAPNtPDILE | HPRD | |
| T91 | RYLLGtSLARP | HPRD | |
| Y133 | FELSCySLAPQ | Arginosuc_synth | PhosphoSitePlus |
| Y322 | FAELVyTGFWH | Arginosuc_synth | PhosphoSitePlus |
| Y83 | QSSALyEDRYL | Arginosuc_synth | PhosphoSitePlus |
| S180 | PKNPWsMDENL | HPRD | |
| Y87 | LYEDRyLLGTS | Arginosuc_synth | PhosphoSitePlus |
| Y359 | LKGQVyILGRE | Arginosuc_synth | PhosphoSitePlus |
| T219 | AKAPNtPDILE | Arginosuc_synth | PhosphoSitePlus |
| T174 | IPIPVtPKNPW | HPRD | |
| Y113 | REGAKyVSHGA | Arginosuc_synth | PhosphoSitePlus |
| S92 | YLLGTsLARPC | HPRD | |
| Y282 | KSRGIyETPAG | HPRD | |
| S134 | ELSCYsLAPQI | Arginosuc_synth | PhosphoSitePlus |
| Y291 | AGTILyHAHLD | Arginosuc_synth | PhosphoSitePlus |
| Dephosphorylation site |
| ASSY_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361469 | K412T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361471 | K412T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361469 | K412T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361470 | K412T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000253004 | K412T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000361469 | T210I | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000361470 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.2 | 18715028 | ENSP00000361470 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.27 | 14726492 | ENSP00000361470 | hepatitis B virus | Normal vs. Cancer | tissue | Down | 0.088 | 14654528 | ENSP00000361470 | hepatitis C virus | Normal vs. Cancer | tissue | Down | 0.088 | 14654528 | ENSP00000361470 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.088 | 14654528 | ENSP00000361470 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 18571811 | ENSP00000361470 | Hepatocellular Carcinoma | Normal vs. Cancer | tissue | Down | 0.5 | 19956837 | ENSP00000361470 | Breast Cancer | Normal vs. Cancer | cell line | Up | 4.9 | 20198662 | ENSP00000361470 | Breast Cancer | Metastasis | cell line | Up | 2.2 | 20198662 | ENSP00000361470 | Renal Cancer | Normal vs. Cancer | tissue | Down | 0.43 | 12923786 | ENSP00000361470 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | ENSP00000361470 | Gastric Cancer | Treatment (none vs. drug-resistant) | cell line | Up | 1.7 | 20625496 |
| Hyperphosphorylation site |
| ASSY_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | ASSY_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| ASSY_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006526 | arginine biosynthetic process | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0034641 | cellular nitrogen compound metabolic process | TAS | biological_process |
| GO:0000050 | urea cycle | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0004055 | argininosuccinate synthase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | TAS | cellular_component |