| UniProt/SwissProt ID: | CCND3_HUMAN |
| Description: | cyclin D3 [Source:HGNC Symbol;Acc:1585] |
| Location: | chr6 p21.1 |
| Node attribute: | substrate; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T283 | PSQTStPTDVT | GSK-3_beta | phosphoELM |
| S264 | SQTSSsPAPKA | Cyclin_C | PhosphoSitePlus |
| S263 | ASQTSsSPAPK | Cyclin_C | PhosphoSitePlus |
| S282 | GPSQTsTPTDV | PhosphoSitePlus | |
| S263 | ASQTSsSPAPK | HPRD; phosphoELM | |
| T283 | PSQTStPTDVT | GSK3B(GSK3 beta | RegPhos |
| T281 | QGPSQtSTPTD | PhosphoSitePlus | |
| T9 | LCCEGtRHAPR | PhosphoSitePlus | |
| S264 | SQTSSsPAPKA | HPRD; phosphoELM | |
| T283 | PSQTStPTDVT | PhosphoSitePlus | |
| T261 | REASQtSSSPA | Cyclin_C | PhosphoSitePlus |
| S279 | SSQGPsQTSTP | Cyclin_C | PhosphoSitePlus |
| Dephosphorylation site |
| CCND3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362082 | R172C | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000362082 | Neoplasms by Histologic Type | Cancer vs. Cancer (progression) | tissue | Up | 15098007 | |
| Hyperphosphorylation site |
| CCND3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GSK3B_HUMAN | CCND3_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| SP1_HUMAN | CCND3_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04510 | Focal adhesion |
| hsa04110 | Cell cycle |
| hsa04310 | Wnt signaling pathway |
| hsa05166 | HTLV-I infection |
| hsa04115 | p53 signaling pathway |
| hsa05162 | Measles |
| hsa05203 | Viral carcinogenesis |
| hsa04630 | Jak-STAT signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045737 | positive regulation of cyclin-dependent protein ki | IDA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0001934 | positive regulation of protein phosphorylation | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0051726 | regulation of cell cycle | IEA | biological_process |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0000307 | cyclin-dependent protein kinase holoenzyme complex | IDA | cellular_component |
| GO:0042098 | T cell proliferation | IEA | biological_process |
| GO:0000079 | regulation of cyclin-dependent protein kinase acti | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0004693 | cyclin-dependent protein kinase activity | IEA | molecular_function |
| GO:0051301 | cell division | IEA | biological_process |