Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:FURIN_HUMAN
Description:furin (paired basic amino acid cleaving enzyme) [Source:HGNC Symbol;Acc:8568]
Location:chr15 q26.1
Node attribute:cleavage(source); gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y167DLAGNyDPGASPeptidase_S8PhosphoSitePlus
S775ECPSDsEEDEGPhosphoSitePlus
Y123FPQQWyLSGVTPhosphoSitePlus
S773QEECPsDSEEDPhosphoSitePlus

Dephosphorylation site
FURIN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000268171G755DCOSMICCentral Nervous System Neoplasms18772890
ENSP00000268171G284ACOSMICLung Cancer20668451
ENSP00000268171G755DTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000268171G653ECOSMICOvarian Cancer21720365
ENSP00000268171D778VCOSMICLung Cancer20668451
ENSP00000268171A574TTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000268171P654STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000268171A574TCOSMICCentral Nervous System Neoplasms18772890
ENSP00000268171G653ETCGAOvarian Cancer21720365, 18772890
ENSP00000268171P654SCOSMICCentral Nervous System Neoplasms18772890

Differential expressed protein
FURIN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
FURIN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
FURIN_HUMANNOTC1_HUMANcleavageNetPath
SP1_HUMANFURIN_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05164Influenza A

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030198extracellular matrix organizationTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0032455nerve growth factor processingTASbiological_process
GO:0004867serine-type endopeptidase inhibitor activityIDAmolecular_function
GO:0032940secretion by cellIDAbiological_process
GO:0043043peptide biosynthetic processIDAbiological_process
GO:0002020protease bindingIPImolecular_function
GO:0032902nerve growth factor productionIDAbiological_process
GO:0007219Notch signaling pathwayTASbiological_process
GO:0051044positive regulation of membrane protein ectodomainICbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0022617extracellular matrix disassemblyTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0030140trans-Golgi network transport vesicleIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006508proteolysisIEAbiological_process
GO:0043687post-translational protein modificationTASbiological_process
GO:0004252serine-type endopeptidase activityIEAmolecular_function
GO:0032911negative regulation of transforming growth factor IMPbiological_process
GO:0008283cell proliferationIMPbiological_process
GO:0042277peptide bindingIDAmolecular_function
GO:0000139Golgi membraneTAScellular_component
GO:0032804negative regulation of low-density lipoprotein parIDAbiological_process
GO:0048406nerve growth factor bindingIDAmolecular_function
GO:0052548regulation of endopeptidase activityIDAbiological_process
GO:0044267cellular protein metabolic processTASbiological_process
GO:0019067viral assembly, maturation, egress, and releaseIEPbiological_process
GO:0005802trans-Golgi networkIDAcellular_component
GO:0017187peptidyl-glutamic acid carboxylationTASbiological_process
GO:0006465signal peptide processingIDAbiological_process
GO:0042176regulation of protein catabolic processIMPbiological_process
GO:0005796Golgi lumenTAScellular_component
GO:0008233peptidase activityIDAmolecular_function
GO:0004175endopeptidase activityIDAmolecular_function
GO:0016485protein processingIEAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0009966regulation of signal transductionIEAbiological_process
GO:0045121membrane raftIDAcellular_component
GO:0016486peptide hormone processingIDAbiological_process


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