Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EGLN_HUMAN
Description:endoglin [Source:HGNC Symbol;Acc:3349]
Location:chr9 q34.11
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S634VAAPAsSESSSDUF4199PhosphoSitePlus
T640SESSStNHSIGDUF4199PhosphoSitePlus
T650GSTQStPCSTSPhosphoSitePlus
S635AAPASsESSSTDUF4199PhosphoSitePlus
S649IGSTQsTPCSTDUF4199PhosphoSitePlus
T654STPCStSSMA_PhosphoSitePlus
S646NHSIGsTQSTPDUF4199PhosphoSitePlus

Dephosphorylation site
EGLN_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000341917L251PCOSMICOvarian Cancer21720365

Differential expressed protein
EGLN_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EGLN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANEGLN_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
EGLN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003084positive regulation of systemic arterial blood preIMPbiological_process
GO:0048870cell motilityIMPbiological_process
GO:0016477cell migrationIMPbiological_process
GO:0048845venous blood vessel morphogenesisIEAbiological_process
GO:0072563endothelial microparticleIEAcellular_component
GO:0042325regulation of phosphorylationTASbiological_process
GO:0030336negative regulation of cell migrationIDAbiological_process
GO:0005072transforming growth factor beta receptor, cytoplasIDAmolecular_function
GO:0010862positive regulation of pathway-restricted SMAD proIDAbiological_process
GO:0009897external side of plasma membraneIDAcellular_component
GO:0001947heart loopingISSbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0048745smooth muscle tissue developmentIEAbiological_process
GO:0000122negative regulation of transcription from RNA polyIDAbiological_process
GO:0048745smooth muscle tissue developmentISSbiological_process
GO:0003273cell migration involved in endocardial cushion forIEAbiological_process
GO:0050431transforming growth factor beta bindingIPImolecular_function
GO:0001937negative regulation of endothelial cell proliferatIMPbiological_process
GO:0022617extracellular matrix disassemblyIMPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030512negative regulation of transforming growth factor TASbiological_process
GO:0042127regulation of cell proliferationTASbiological_process
GO:0005024transforming growth factor beta-activated receptorIDAmolecular_function
GO:0030155regulation of cell adhesionTASbiological_process
GO:0001947heart loopingIEAbiological_process
GO:0070483detection of hypoxiaIDAbiological_process
GO:0042060wound healingIMPbiological_process
GO:0042803protein homodimerization activityIEAmolecular_function
GO:0031953negative regulation of protein autophosphorylationIDAbiological_process
GO:0070022transforming growth factor beta receptor homodimerICcellular_component
GO:0022009central nervous system vasculogenesisIMPbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0030513positive regulation of BMP signaling pathwayIDAbiological_process
GO:0048845venous blood vessel morphogenesisISSbiological_process
GO:0001569patterning of blood vesselsIEAbiological_process
GO:0007179transforming growth factor beta receptor signalingIDAbiological_process
GO:0048844artery morphogenesisIEAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0005534galactose bindingIDAmolecular_function
GO:0050431transforming growth factor beta bindingIEAmolecular_function
GO:0001570vasculogenesisIMPbiological_process
GO:0048844artery morphogenesisISSbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0001934positive regulation of protein phosphorylationIDAbiological_process
GO:0001300chronological cell agingIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0001666response to hypoxiaIDAbiological_process
GO:0004888transmembrane signaling receptor activityNASmolecular_function
GO:0017015regulation of transforming growth factor beta receIDAbiological_process
GO:0001569patterning of blood vesselsISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0009986cell surfaceIDAcellular_component
GO:0060326cell chemotaxisIMPbiological_process
GO:0005539glycosaminoglycan bindingIDAmolecular_function
GO:0060394negative regulation of pathway-restricted SMAD proIMPbiological_process
GO:0030509BMP signaling pathwayTASbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0007155cell adhesionIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIMPbiological_process
GO:0048185activin bindingTASmolecular_function
GO:0051001negative regulation of nitric-oxide synthase activIMPbiological_process
GO:0034713type I transforming growth factor beta receptor biIPImolecular_function
GO:0005114type II transforming growth factor beta receptor bIPImolecular_function