Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDGFB_HUMAN
Description:platelet-derived growth factor beta polypeptide [Source:HGNC Symbol;Acc:8800]
Location:chr22 q13.1
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PDGFB_HUMAN do not have phosphorylation site.

Dephosphorylation site
PDGFB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000330382R39CCOSMICHead and Neck Cancer21798893
ENSP00000330382*242SCOSMICBreast Cancer16959974

Differential expressed protein
PDGFB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDGFB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDGFB_HUMANPGFRA_HUMANligand -> receptorHPMR
PDGFB_HUMANPGFRB_HUMANligand -> receptorHPMR
PDGFB_HUMANPGFRA_HUMANotherKEGG
PDGFB_HUMANPGFRB_HUMANotherKEGG
SP1_HUMANPDGFB_HUMANTF -> target geneTRANSFAC
ZN174_HUMANPDGFB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05214Glioma
hsa05211Renal cell carcinoma
hsa04060Cytokine-cytokine receptor interaction
hsa04810Regulation of actin cytoskeleton
hsa04010MAPK signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05218Melanoma
hsa05166HTLV-I infection
hsa04540Gap junction
hsa04510Focal adhesion

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048514blood vessel morphogenesisIEAbiological_process
GO:0008083growth factor activityIEAmolecular_function
GO:0050918positive chemotaxisIDAbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005576extracellular regionNAScellular_component
GO:0010512negative regulation of phosphatidylinositol biosynIDAbiological_process
GO:0005518collagen bindingIDAmolecular_function
GO:0030168platelet activationTASbiological_process
GO:0032147activation of protein kinase activityIDAbiological_process
GO:0002576platelet degranulationTASbiological_process
GO:0048407platelet-derived growth factor bindingIPImolecular_function
GO:0009611response to woundingNASbiological_process
GO:0060445branching involved in salivary gland morphogenesisIEAbiological_process
GO:0072126positive regulation of glomerular mesangial cell pIDAbiological_process
GO:0043410positive regulation of MAPK cascadeIMPbiological_process
GO:0016176superoxide-generating NADPH oxidase activator actiIDAmolecular_function
GO:0031093platelet alpha granule lumenTAScellular_component
GO:0043499eukaryotic cell surface bindingIDAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0042060wound healingIEAbiological_process
GO:0032148activation of protein kinase B activityIDAbiological_process
GO:0061098positive regulation of protein tyrosine kinase actIDAbiological_process
GO:0007507heart developmentIEAbiological_process
GO:0002548monocyte chemotaxisIDAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0050921positive regulation of chemotaxisIDAbiological_process
GO:0072262metanephric glomerular mesangial cell proliferatioIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0071363cellular response to growth factor stimulusIDAbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0006929substrate-dependent cell migrationIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0042056chemoattractant activityIDAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:2000591positive regulation of metanephric mesenchymal celIEAbiological_process
GO:0030031cell projection assemblyIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0043536positive regulation of blood vessel endothelial ceIDAbiological_process
GO:0043498cell surface bindingIEAmolecular_function
GO:0050731positive regulation of peptidyl-tyrosine phosphoryIDAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0035793positive regulation of metanephric mesenchymal celIDAbiological_process
GO:0072593reactive oxygen species metabolic processIMPbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0001938positive regulation of endothelial cell proliferatIEAbiological_process
GO:0005161platelet-derived growth factor receptor bindingIEAmolecular_function
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0060326cell chemotaxisIDAbiological_process
GO:0045737positive regulation of cyclin-dependent protein kiIDAbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0072264metanephric glomerular endothelium developmentIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0010544negative regulation of platelet activationIDAbiological_process
GO:0090280positive regulation of calcium ion importIDAbiological_process
GO:0038001paracrine signalingIEAbiological_process
GO:0050730regulation of peptidyl-tyrosine phosphorylationIEAbiological_process
GO:0070374positive regulation of ERK1 and ERK2 cascadeIDAbiological_process
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0043627response to estrogen stimulusIEAbiological_process
GO:0043552positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0016323basolateral plasma membraneIEAcellular_component
GO:1900127positive regulation of hyaluronan biosynthetic proIDAbiological_process
GO:0043406positive regulation of MAP kinase activityIEAbiological_process
GO:0008284positive regulation of cell proliferationIDAbiological_process
GO:0046982protein heterodimerization activityIPImolecular_function
GO:0007179transforming growth factor beta receptor signalingIEAbiological_process
GO:0000139Golgi membraneTAScellular_component
GO:2000379positive regulation of reactive oxygen species metIDAbiological_process
GO:0016049cell growthIEAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioIEAbiological_process
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0060664epithelial cell proliferation involved in salivaryIEAbiological_process
GO:2000573positive regulation of DNA biosynthetic processIDAbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0031954positive regulation of protein autophosphorylationIDAbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0045840positive regulation of mitosisIDAbiological_process
GO:0032868response to insulin stimulusIEAbiological_process
GO:0071506cellular response to mycophenolic acidIEAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0001892embryonic placenta developmentIEAbiological_process
GO:0072255metanephric glomerular mesangial cell developmentIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0003104positive regulation of glomerular filtrationIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaIDAbiological_process
GO:0045743positive regulation of fibroblast growth factor reIEAbiological_process