Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:DPOLB_HUMAN
Description:polymerase (DNA directed), beta [Source:HGNC Symbol;Acc:9174]
Location:chr8 p11.21
Node attribute:gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y39HKYNAyRKAASPhosphoSitePlus
S44YRKAAsVIAKYHPRD
T67LPGVGtKIAEKPhosphoSitePlus
Y49SVIAKyPHKIKPhosphoSitePlus
S180ATVCGsFRRGAPhosphoSitePlus
S55PHKIKsGAEAKHPRD
Y36QAIHKyNAYRKPhosphoSitePlus
Y250NDEKEyPHRRIPhosphoSitePlus

Dephosphorylation site
DPOLB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265421G80RCOSMICOvarian Cancer21720365
ENSP00000265421N37HBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000265421N281SCOSMICHepatocellular Carcinoma21822264

Differential expressed protein
DPOLB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
DPOLB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
SP1_HUMANDPOLB_HUMANTF -> target geneTRANSFAC
ATF2_HUMANDPOLB_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
DPOLB_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0003824catalytic activityIEAmolecular_function
GO:0003684damaged DNA bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005654nucleoplasmTAScellular_component
GO:0005876spindle microtubuleIDAcellular_component
GO:0016829lyase activityIDAmolecular_function
GO:0006974response to DNA damage stimulusIMPbiological_process
GO:0008017microtubule bindingIDAmolecular_function
GO:0006284base-excision repairIDAbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0006281DNA repairTASbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0019899enzyme bindingIPImolecular_function
GO:0003677DNA bindingIEAmolecular_function
GO:0008219cell deathIEAbiological_process
GO:0005874microtubuleIDAcellular_component
GO:0016779nucleotidyltransferase activityIEAmolecular_function
GO:0003887DNA-directed DNA polymerase activityIEAmolecular_function
GO:0006290pyrimidine dimer repairIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0006261DNA-dependent DNA replicationTASbiological_process


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