| UniProt/SwissProt ID: | EPOR_HUMAN |
| Description: | erythropoietin receptor [Source:HGNC Symbol;Acc:3416] |
| Location: | chr19 p13.2 |
| Node attribute: | PPI(target); substrate; receptor; gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y504 | PLPPSyVA | phosphoELM | |
| Y485 | LSDGPySNPYE | JAK2 | RegPhos |
| Y489 | PYSNPyENSLI | JAK2 | RegPhos |
| Y485 | LSDGPySNPYE | PhosphoSitePlus | |
| S115 | PTADTsSFVPL | EpoR_lig-bind | PhosphoSitePlus |
| Y504 | PLPPSyVA | JAK2 | HPRD |
| Y489 | PYSNPyENSLI | JAK2 | HPRD; RegPhos |
| Y504 | PLPPSyVACS | JAK2 | RegPhos |
| Y485 | LSDGPySNPYE | JAK2 | HPRD; RegPhos |
| Y368 | HAQDTyLVLDK | JAK2 | HPRD; phosphoELM; RegPhos |
| Y426 | AASFEyTILDP | JAK2 | RegPhos |
| S108 | VRFWCsLPTAD | EpoR_lig-bind | PhosphoSitePlus |
| Y504 | PLPPSyVACS_ | PhosphoSitePlus | |
| Y309 | FQLWLyQNDGC | PhosphoSitePlus | |
| Y426 | AASFEyTILDP | JAK2 | HPRD; RegPhos |
| Y456 | HLKYLyLVVSD | JAK2 | RegPhos |
| Y504 | PLPPSyVACS | RegPhos | |
| Y504 | PLPPSyVACS | JAK2 | RegPhos |
| Y368 | HAQDTyLVLDK | Lyn | phosphoELM; RegPhos |
| Y426 | AASFEyTILDP | PhosphoSitePlus; phosphoELM | |
| S192 | GNGAGsVQRVE | fn3 | PhosphoSitePlus |
| Y456 | HLKYLyLVVSD | JAK2 | HPRD; RegPhos |
| Y468 | GISTDySSGDS | JAK2 | HPRD; RegPhos |
| Y368 | HAQDTyLVLDK | PhosphoSitePlus | |
| S185 | YEVDVsAGNGA | fn3 | PhosphoSitePlus |
| Y454 | PPHLKyLYLVV | JAK2 | HPRD; RegPhos |
| Y468 | GISTDySSGDS | PhosphoSitePlus | |
| Y454 | PPHLKyLYLVV | JAK2 | RegPhos |
| Y368 | HAQDTyLVLDK | JAK2 | RegPhos |
| Y468 | GISTDySSGDS | JAK2 | RegPhos |
| Y454 | PPHLKyLYLVV | PhosphoSitePlus; phosphoELM | |
| Y489 | PYSNPyENSLI | PhosphoSitePlus; phosphoELM; RegPhos | |
| Y456 | HLKYLyLVVSD | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| EPOR_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000222139 | T466I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000222139 | N487S | OMIM | Leukemia | 8608241 1653276 |
| Differential expressed protein |
| EPOR_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| EPOR_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PERE_HUMAN | EPOR_HUMAN | ligand -> receptor | HPMR |
| JAK2_HUMAN | EPOR_HUMAN | kinase -> substrate | RegPhos; Robert H Newman (2013) |
| ZAGL2_HUMAN | EPOR_HUMAN | kinase -> substrate | RegPhos |
| LYN_HUMAN | EPOR_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PERE_HUMAN | EPOR_HUMAN | other | KEGG |
| SP1_HUMAN | EPOR_HUMAN | TF -> target gene | TRANSFAC |
| GATA2_HUMAN | EPOR_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04630 | Jak-STAT signaling pathway |
| hsa04640 | Hematopoietic cell lineage |
| hsa04060 | Cytokine-cytokine receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0009790 | embryo development | IEA | biological_process |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0046697 | decidualization | IEA | biological_process |
| GO:0004900 | erythropoietin receptor activity | IDA | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0038162 | erythropoietin-mediated signaling pathway | IDA | biological_process |
| GO:0007165 | signal transduction | NAS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0005576 | extracellular region | IEA | cellular_component |
| GO:0004888 | transmembrane signaling receptor activity | IEA | molecular_function |
| GO:0007507 | heart development | IEA | biological_process |
| GO:0042802 | identical protein binding | IPI | molecular_function |