Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EPOR_HUMAN
Description:erythropoietin receptor [Source:HGNC Symbol;Acc:3416]
Location:chr19 p13.2
Node attribute:PPI(target); substrate; receptor; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y504PLPPSyVAphosphoELM
Y485LSDGPySNPYEJAK2 RegPhos
Y489PYSNPyENSLIJAK2 RegPhos
Y485LSDGPySNPYEPhosphoSitePlus
S115PTADTsSFVPLEpoR_lig-bindPhosphoSitePlus
Y504PLPPSyVAJAK2HPRD
Y489PYSNPyENSLIJAK2HPRD; RegPhos
Y504PLPPSyVACSJAK2RegPhos
Y485LSDGPySNPYEJAK2HPRD; RegPhos
Y368HAQDTyLVLDKJAK2HPRD; phosphoELM; RegPhos
Y426AASFEyTILDPJAK2 RegPhos
S108VRFWCsLPTADEpoR_lig-bindPhosphoSitePlus
Y504PLPPSyVACS_PhosphoSitePlus
Y309FQLWLyQNDGCPhosphoSitePlus
Y426AASFEyTILDPJAK2HPRD; RegPhos
Y456HLKYLyLVVSDJAK2 RegPhos
Y504PLPPSyVACSRegPhos
Y504PLPPSyVACSJAK2 RegPhos
Y368HAQDTyLVLDKLynphosphoELM; RegPhos
Y426AASFEyTILDPPhosphoSitePlus; phosphoELM
S192GNGAGsVQRVEfn3PhosphoSitePlus
Y456HLKYLyLVVSDJAK2HPRD; RegPhos
Y468GISTDySSGDSJAK2HPRD; RegPhos
Y368HAQDTyLVLDKPhosphoSitePlus
S185YEVDVsAGNGAfn3PhosphoSitePlus
Y454PPHLKyLYLVVJAK2HPRD; RegPhos
Y468GISTDySSGDSPhosphoSitePlus
Y454PPHLKyLYLVVJAK2 RegPhos
Y368HAQDTyLVLDKJAK2 RegPhos
Y468GISTDySSGDSJAK2 RegPhos
Y454PPHLKyLYLVVPhosphoSitePlus; phosphoELM
Y489PYSNPyENSLIPhosphoSitePlus; phosphoELM; RegPhos
Y456HLKYLyLVVSDPhosphoSitePlus; phosphoELM

Dephosphorylation site
EPOR_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000222139T466ICOSMICOvarian Cancer21720365
ENSP00000222139N487SOMIMLeukemia8608241 1653276

Differential expressed protein
EPOR_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EPOR_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PERE_HUMANEPOR_HUMANligand -> receptorHPMR
JAK2_HUMANEPOR_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANEPOR_HUMANkinase -> substrateRegPhos
LYN_HUMANEPOR_HUMANkinase -> substrateRobert H Newman (2013)
PERE_HUMANEPOR_HUMANotherKEGG
SP1_HUMANEPOR_HUMANTF -> target geneTRANSFAC
GATA2_HUMANEPOR_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0007420brain developmentIEAbiological_process
GO:0046697decidualizationIEAbiological_process
GO:0004900erythropoietin receptor activityIDAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0038162erythropoietin-mediated signaling pathwayIDAbiological_process
GO:0007165signal transductionNASbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005576extracellular regionIEAcellular_component
GO:0004888transmembrane signaling receptor activityIEAmolecular_function
GO:0007507heart developmentIEAbiological_process
GO:0042802identical protein bindingIPImolecular_function


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