Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CO1A1_HUMAN
Description:collagen, type I, alpha 1 [Source:HGNC Symbol;Acc:2197]
Location:chr17 q21.33
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S867KGARGsAGPPGCollagenPhosphoSitePlus
T172YDEKStGGISVHPRD
S889GPPGPsGNAGPCollagenPhosphoSitePlus
S546TGSPGsPGPDGCollagenPhosphoSitePlus
S171GYDEKsTGGISHPRD
S176STGGIsVPGPMHPRD
S1125PGPPGsPGEQGCollagenPhosphoSitePlus
S1023PGAEGsPGRDGCollagenPhosphoSitePlus
S543KGLTGsPGSPGCollagenPhosphoSitePlus

Dephosphorylation site
CO1A1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225964P343SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000225964L1235FCOSMICCentral Nervous System Neoplasms18772890
ENSP00000225964P204LCOSMICSkin Cancer21984974
ENSP00000225964R220*COSMICCentral Nervous System Neoplasms18772890
ENSP00000225964G434DCOSMICCentral Nervous System Neoplasms18772890
ENSP00000225964R244HCOSMICPancreatic Cancer21252315
ENSP00000225964G446ACOSMICOvarian Cancer21720365
ENSP00000225964D613NCOSMICMelanoma21499247
ENSP00000225964E1015*COSMICHepatocellular Carcinoma21822264
ENSP00000225964G629DCOSMICBreast Cancer19812674
ENSP00000225964P774SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000225964A589PCOSMICHead and Neck Cancer21798893
ENSP00000225964E288DCOSMICHead and Neck Cancer21798893

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000225964hepatitis C virusNormal vs. CancertissueDown0.418715028
ENSP00000225964papillary thyroid carcinomaNormal vs. CancertissueDown0.2616788983
ENSP00000225964papillary thyroid carcinomaNormal vs. CancertissueDown0.2716788983
ENSP00000225964breast ductal carcinomaNormal vs. CancertissueUp18482919
ENSP00000225964Neoplasms by Histologic TypeCancer vs. Cancer (subtype)tissueDown0.4416807943
ENSP00000225964Ovarian CancerMetastasiscell lineDown0.0817892554
ENSP00000225964Gastric CancerNormal vs. Cancercell lineDown0.0920812763
ENSP00000225964Gastric CancerNormal vs. Cancercell lineDown0.0520812763

Hyperphosphorylation site
CO1A1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CO1A1_HUMANDDR1_HUMANligand -> receptorHPMR
CO1A1_HUMANDDR2_HUMANligand -> receptorHPMR
CO1A1_HUMANSDC1_HUMANotherKEGG
CO1A1_HUMANGPVI_HUMANotherKEGG
CO1A1_HUMANCD44_HUMANotherKEGG
SP1_HUMANCO1A1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05146Amoebiasis
hsa04510Focal adhesion
hsa04974Protein digestion and absorption
hsa04512ECM-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0042060wound healingIEAbiological_process
GO:0005584collagen type IIEAcellular_component
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0001957intramembranous ossificationIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0005788endoplasmic reticulum lumenTAScellular_component
GO:0007605sensory perception of soundIMPbiological_process
GO:0007411axon guidanceTASbiological_process
GO:0010812negative regulation of cell-substrate adhesionIEAbiological_process
GO:0071363cellular response to growth factor stimulusIEAbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0071560cellular response to transforming growth factor beIEAbiological_process
GO:0010035response to inorganic substanceIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005615extracellular spaceIEAcellular_component
GO:0007584response to nutrientIEAbiological_process
GO:0001649osteoblast differentiationIEAbiological_process
GO:0031012extracellular matrixIDAcellular_component
GO:0007596blood coagulationTASbiological_process
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0030199collagen fibril organizationIMPbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0005615extracellular spaceIDAcellular_component
GO:0031960response to corticosteroid stimulusIEAbiological_process
GO:0001568blood vessel developmentIEAbiological_process
GO:0042802identical protein bindingIDAmolecular_function
GO:0034504protein localization to nucleusIDAbiological_process
GO:0030198extracellular matrix organizationTASbiological_process
GO:0070208protein heterotrimerizationIEAbiological_process
GO:0090263positive regulation of canonical Wnt receptor signIDAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0034505tooth mineralizationIMPbiological_process
GO:0005581collagenIEAcellular_component
GO:0051591response to cAMPIEAbiological_process
GO:0048706embryonic skeletal system developmentIMPbiological_process
GO:0001568blood vessel developmentIMPbiological_process
GO:0005584collagen type IIMPcellular_component
GO:0001958endochondral ossificationIEAbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tIDAbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0031012extracellular matrixIEAcellular_component
GO:0060351cartilage development involved in endochondral bonIEAbiological_process
GO:0048407platelet-derived growth factor bindingIDAmolecular_function
GO:0005201extracellular matrix structural constituentIEAmolecular_function
GO:0043589skin morphogenesisIMPbiological_process
GO:0005578proteinaceous extracellular matrixIEAcellular_component
GO:0030335positive regulation of cell migrationIDAbiological_process
GO:0043588skin developmentIEAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0071300cellular response to retinoic acidIEAbiological_process
GO:0032964collagen biosynthetic processIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0001501skeletal system developmentIMPbiological_process
GO:0060346bone trabecula formationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007601visual perceptionIMPbiological_process
GO:0060325face morphogenesisIEAbiological_process
GO:0001501skeletal system developmentIEAbiological_process