Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:EDA_HUMAN
Description:ectodysplasin A [Source:HGNC Symbol;Acc:3157]
Location:chrX q13.1
Node attribute:PPI(source); ligand; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S374ISINMsKHTTFTNFPhosphoSitePlus

Dephosphorylation site
EDA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363680L42RCOSMICOvarian Cancer21720365
ENSP00000363680P118LSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000363680L62ICOSMICOvarian Cancer21720365
ENSP00000363680P118LHPIColorectal Cancer16959974
ENSP00000363681L42RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
EDA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
EDA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
EDA_HUMANTNR27_HUMANligand -> receptorHPMR
EDA_HUMANEDAR_HUMANligand -> receptorHPMR
EDA_HUMANTNR27_HUMANotherKEGG
EDA_HUMANEDAR_HUMANotherKEGG
SP1_HUMANEDA_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04060Cytokine-cytokine receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0090263positive regulation of canonical Wnt receptor signIEAbiological_process
GO:0010467gene expressionIEAbiological_process
GO:0005856cytoskeletonTAScellular_component
GO:0043588skin developmentIEAbiological_process
GO:0005581collagenIEAcellular_component
GO:0030154cell differentiationIEAbiological_process
GO:0016021integral to membraneTAScellular_component
GO:0045177apical part of cellIEAcellular_component
GO:0016020membraneTAScellular_component
GO:0005886plasma membraneTAScellular_component
GO:0061153trachea gland developmentIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0060789hair follicle placode formationIEAbiological_process
GO:0005102receptor bindingIDAmolecular_function
GO:0006955immune responseIEAbiological_process
GO:0007165signal transductionTASbiological_process
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0005164tumor necrosis factor receptor bindingIEAmolecular_function
GO:0043473pigmentationIEAbiological_process
GO:0007160cell-matrix adhesionIEAbiological_process
GO:0042346positive regulation of NF-kappaB import into nucleIEAbiological_process
GO:0007398ectoderm developmentTASbiological_process
GO:0005887integral to plasma membraneIEAcellular_component
GO:0001942hair follicle developmentIEAbiological_process
GO:0060662salivary gland cavitationIEAbiological_process


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