| UniProt/SwissProt ID: | CO1A2_HUMAN |
| Description: | collagen, type I, alpha 2 [Source:HGNC Symbol;Acc:2198] |
| Location: | chr7 q21.3 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T1148 | NNQIEtLLTPE | PhosphoSitePlus | |
| S710 | AGPRGsPGERG | Collagen | PhosphoSitePlus |
| S1155 | LTPEGsRKNPA | COLFI | PhosphoSitePlus |
| S1141 | DATLKsLNNQI | PhosphoSitePlus | |
| T981 | GNRGEtGPSGP | Collagen | PhosphoSitePlus |
| T1073 | TGHPGtVGPAG | Collagen | PhosphoSitePlus |
| S1104 | GPPGVsGGGYD | Collagen | PhosphoSitePlus |
| S1295 | VILQGsNDVEL | COLFI | PhosphoSitePlus |
| S389 | NGEAGsAGPPG | Collagen | PhosphoSitePlus |
| Dephosphorylation site |
| CO1A2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000297268 | A843T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000297268 | G271S | BIOMART | Brain Cancer | 21930507, 21930502 | ENSP00000297268 | P230S | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000297268 | G937S | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000297268 | P230S | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 | ENSP00000297268 | K1273R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000297268 | P40R | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000297268 | P92T | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000297268 | A843T | COSMIC | Ovarian Cancer | 21720365 | ENSP00000297268 | R938H | COSMIC | Central Nervous System Neoplasms | 18772890 | ENSP00000297268 | G74C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000297268 | G937S | COSMIC | Ovarian Cancer | 21720365 | ENSP00000297268 | G655R | COSMIC | Skin Cancer | 21984974 | ENSP00000297268 | E644* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000297268 | G1229E | COSMIC | Melanoma | 21499247 | ENSP00000297268 | P936S | COSMIC | Skin Cancer | 21984974 | ENSP00000297268 | Y1240C | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000297268 | R938H | TCGA | Neoplasms by Histologic Type | 21720365, 18772890 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000297268 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18482919 | ENSP00000297268 | breast ductal carcinoma | Normal vs. Cancer | tissue | Up | 18564057 | ENSP00000297268 | Gastric Cancer | Normal vs. Cancer | cell line | Down | 0.1 | 20812763 | ENSP00000297268 | Gastric Cancer | Normal vs. Cancer | cell line | Down | 0.05 | 20812763 |
| Hyperphosphorylation site |
| CO1A2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SP1_HUMAN | CO1A2_HUMAN | TF -> target gene | TRANSFAC |
| SMAD3_HUMAN | CO1A2_HUMAN | TF -> target gene | TRANSFAC |
| TF65_HUMAN | CO1A2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| CO1A2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005201 | extracellular matrix structural constituent | NAS | molecular_function |
| GO:0030198 | extracellular matrix organization | TAS | biological_process |
| GO:0005584 | collagen type I | IMP | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0042476 | odontogenesis | NAS | biological_process |
| GO:0042802 | identical protein binding | IDA | molecular_function |
| GO:0001568 | blood vessel development | IMP | biological_process |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0005581 | collagen | IEA | cellular_component |
| GO:0007179 | transforming growth factor beta receptor signaling | IDA | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0048407 | platelet-derived growth factor binding | IDA | molecular_function |
| GO:0008217 | regulation of blood pressure | IMP | biological_process |
| GO:0007266 | Rho protein signal transduction | IDA | biological_process |
| GO:0043589 | skin morphogenesis | IMP | biological_process |
| GO:0030199 | collagen fibril organization | IMP | biological_process |
| GO:0030168 | platelet activation | TAS | biological_process |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0030674 | protein binding, bridging | IMP | molecular_function |
| GO:0001501 | skeletal system development | IMP | biological_process |
| GO:0071230 | cellular response to amino acid stimulus | IEA | biological_process |
| GO:0050900 | leukocyte migration | TAS | biological_process |
| GO:0005584 | collagen type I | IEA | cellular_component |
| GO:0046332 | SMAD binding | IEA | molecular_function |
| GO:0070208 | protein heterotrimerization | IEA | biological_process |
| GO:0005788 | endoplasmic reticulum lumen | TAS | cellular_component |