Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	CCND1_HUMAN
Description:	cyclin D1 [Source:HGNC Symbol;Acc:1582]
Location:	chr11 q13.3
Node attribute:	PPI(target); substrate; gene

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S234	LTRFLsRVIKC	PKA_group	phosphoELM; RegPhos
S234	LTRFLsRVIKC	PRKACA	HPRD
S90	LDRFLsLEPVK	PRKACA	HPRD
S197	DVKFIsNPPSM	Cyclin_C	PhosphoSitePlus
S197	DVKFIsNPPSM	PKA_group	phosphoELM; RegPhos
T286	VDLACtPTDVR	GSK-3_group	phosphoELM
S197	DVKFIsNPPSM	PKACa	RegPhos
Y226	NNFLSyYRLTR	Cyclin_C	PhosphoSitePlus
T286	VDLACtPTDVR	GSK_group	RegPhos
T286	VDLACtPTDVR	IKKa(IKK alpha	RegPhos
S234	LTRFLsRVIKC	PKACa	RegPhos
T286	VDLACtPTDVR	GSK3B	HPRD; RegPhos
S131	IYTDNsIRPEE	Cyclin_N	PhosphoSitePlus
T286	VDLACtPTDVR		PhosphoSitePlus
T286	VDLACtPTDVR	IKK_alpha	phosphoELM
S90	LDRFLsLEPVK	PKA_group	phosphoELM; RegPhos
S234	LTRFLsRVIKC	Cyclin_C	PhosphoSitePlus
S90	LDRFLsLEPVK	Cyclin_N	PhosphoSitePlus
S197	DVKFIsNPPSM	PRKACA	HPRD
T288	LACTPtDVRDV		PhosphoSitePlus
S90	LDRFLsLEPVK	PKACa	RegPhos

Dephosphorylation site

CCND1_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000227507	Q4P	COSMIC	Lung Cancer	20668451

Differential expressed protein

CCND1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

CCND1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
GSK3B_HUMAN	CCND1_HUMAN	kinase -> substrate	KEGG; HPRD; RegPhos
KPCA_HUMAN	CCND1_HUMAN	kinase -> substrate	HPRD
MYC_HUMAN	CCND1_HUMAN	other	KEGG
FOS_HUMAN	CCND1_HUMAN	other	KEGG
LEF1_HUMAN	CCND1_HUMAN	other	KEGG
JUN_HUMAN	CCND1_HUMAN	other	KEGG
CTNB1_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
ELK1_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
LEF1_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
STAT1_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
SOS1_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
JUN_HUMAN	CCND1_HUMAN	TF -> target gene	KEGG
E2F1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
SP3_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
SP2_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
JUND_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
TF65_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
SP4_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
PO2F1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
STA5B_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
LEF1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
CREM_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
SP1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
EP300_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
STA5A_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
USF1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
ETS2_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
CREB1_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
JUN_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC
TF7L2_HUMAN	CCND1_HUMAN	TF -> target gene	TRANSFAC

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05215	Prostate cancer
hsa05203	Viral carcinogenesis
hsa04110	Cell cycle
hsa04310	Wnt signaling pathway
hsa05220	Chronic myeloid leukemia
hsa05214	Glioma
hsa05162	Measles
hsa05210	Colorectal cancer
hsa04510	Focal adhesion
hsa05219	Bladder cancer
hsa04630	Jak-STAT signaling pathway
hsa05218	Melanoma
hsa05416	Viral myocarditis
hsa05213	Endometrial cancer
hsa05216	Thyroid cancer
hsa04115	p53 signaling pathway
hsa05166	HTLV-I infection
hsa05221	Acute myeloid leukemia
hsa05222	Small cell lung cancer
hsa05212	Pancreatic cancer
hsa05200	Pathways in cancer
hsa05223	Non-small cell lung cancer

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0001889	liver development	IEA	biological_process
GO:0033601	positive regulation of mammary gland epithelial ce	IEA	biological_process
GO:0016055	Wnt receptor signaling pathway	IEA	biological_process
GO:0032026	response to magnesium ion	IEA	biological_process
GO:0045737	positive regulation of cyclin-dependent protein ki	IDA	biological_process
GO:0071310	cellular response to organic substance	IEA	biological_process
GO:0005634	nucleus	IDA	cellular_component
GO:0060749	mammary gland alveolus development	IEA	biological_process
GO:0000082	G1/S transition of mitotic cell cycle	TAS	biological_process
GO:0000079	regulation of cyclin-dependent protein kinase acti	IEA	biological_process
GO:0033327	Leydig cell differentiation	IEA	biological_process
GO:0007595	lactation	IEA	biological_process
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IEA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0051726	regulation of cell cycle	IEA	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0042493	response to drug	IEA	biological_process
GO:0001934	positive regulation of protein phosphorylation	IDA	biological_process
GO:0042493	response to drug	IEP	biological_process
GO:0008284	positive regulation of cell proliferation	IEA	biological_process
GO:0000307	cyclin-dependent protein kinase holoenzyme complex	IDA	cellular_component
GO:0016538	cyclin-dependent protein kinase regulator activity	IEA	molecular_function
GO:0014070	response to organic cyclic compound	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0016301	kinase activity	IEA	molecular_function
GO:0005737	cytoplasm	IEA	cellular_component
GO:0010243	response to organic nitrogen	IEA	biological_process
GO:0051412	response to corticosterone stimulus	IEA	biological_process
GO:0000278	mitotic cell cycle	TAS	biological_process
GO:0070141	response to UV-A	IDA	biological_process
GO:0006974	response to DNA damage stimulus	IDA	biological_process
GO:0000080	G1 phase of mitotic cell cycle	TAS	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0043627	response to estrogen stimulus	IEA	biological_process
GO:0007049	cell cycle	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0060070	canonical Wnt receptor signaling pathway	IEA	biological_process
GO:0045471	response to ethanol	IEA	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0031100	organ regeneration	IEA	biological_process
GO:0010165	response to X-ray	IEA	biological_process
GO:0019901	protein kinase binding	IPI	molecular_function
GO:0048545	response to steroid hormone stimulus	IEA	biological_process
GO:0033197	response to vitamin E	IEA	biological_process
GO:0000084	S phase of mitotic cell cycle	TAS	biological_process
GO:2000045	regulation of G1/S transition of mitotic cell cycl	IEA	biological_process
GO:0005622	intracellular	IDA	cellular_component
GO:0045444	fat cell differentiation	IEA	biological_process
GO:0030178	negative regulation of Wnt receptor signaling path	IEA	biological_process
GO:0000320	re-entry into mitotic cell cycle	IEA	biological_process
GO:0019899	enzyme binding	IPI	molecular_function
GO:0033598	mammary gland epithelial cell proliferation	IEA	biological_process
GO:0032403	protein complex binding	IEA	molecular_function
GO:0005923	tight junction	IEA	cellular_component
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0010033	response to organic substance	IEA	biological_process
GO:0051384	response to glucocorticoid stimulus	IEA	biological_process
GO:0030968	endoplasmic reticulum unfolded protein response	IEA	biological_process
GO:0030857	negative regulation of epithelial cell differentia	IEA	biological_process
GO:0010039	response to iron ion	IEA	biological_process
GO:0051592	response to calcium ion	IEA	biological_process
GO:0051301	cell division	IEA	biological_process
GO:0031571	mitotic cell cycle G1/S transition DNA damage chec	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network