Phosphorylation

You are querying signaling transduction network mediated by 5HT2C_HUMAN in Intestines Cancer.

Signaling Transduction Network:

NO.	Source	Target	Relation Attribute	Resource
1	TPH1_HUMAN	5HT2C_HUMAN	ligand -> receptor	HPMR
2	5HT2C_HUMAN	GNAQ_HUMAN	GPCR -> Gprotein	gpDB
3	5HT2C_HUMAN	GNA13_HUMAN	GPCR -> Gprotein	gpDB
4	5HT2C_HUMAN	GNA11_HUMAN	GPCR -> Gprotein	gpDB
5	GNAQ_HUMAN	BTK_HUMAN	Gprotein -> effector	gpDB
6	GNA13_HUMAN	KPCD1_HUMAN	Gprotein -> effector	gpDB
7	GNAQ_HUMAN	PK3CA_HUMAN	Gprotein -> effector	gpDB
8	GNAQ_HUMAN	ARBK1_HUMAN	Gprotein -> effector	gpDB
9	GNAQ_HUMAN	KPCD1_HUMAN	Gprotein -> effector	gpDB
10	GNA11_HUMAN	ARBK1_HUMAN	Gprotein -> effector	gpDB
11	BTK_HUMAN	GTF2I_HUMAN	kinase -> substrate	RegPhos; NetPath; Robert H Newman (2013)
12	BTK_HUMAN	CDK9_HUMAN	kinase -> substrate	Robert H Newman (2013)
13	BTK_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
14	BTK_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
15	KPCD1_HUMAN	KSYK_HUMAN	kinase -> substrate	NetPath
16	BTK_HUMAN	MK08_HUMAN	kinase -> substrate	Robert H Newman (2013)
17	BTK_HUMAN	MK01_HUMAN	kinase -> substrate	Robert H Newman (2013)
18	BTK_HUMAN	STA5A_HUMAN	kinase -> substrate	HPRD; RegPhos
19	BTK_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
20	PK3CA_HUMAN	KS6B1_HUMAN	kinase -> substrate	HPRD
21	ARBK1_HUMAN	P53_HUMAN	kinase -> substrate	Robert H Newman (2013)
22	BTK_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
23	BTK_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
24	BTK_HUMAN	STA5B_HUMAN	kinase -> substrate	Robert H Newman (2013)
25	BTK_HUMAN	ITK_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
26	BTK_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
27	CDK9_HUMAN	CHK2_HUMAN	kinase -> substrate	Robert H Newman (2013)
28	FGR_HUMAN	ZAP70_HUMAN	kinase -> substrate	Robert H Newman (2013)
29	KPCA_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
30	KSYK_HUMAN	KS6A1_HUMAN	kinase -> substrate	NetPath
31	MK08_HUMAN	ELK1_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
32	KPCA_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
33	MK01_HUMAN	CEBPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
34	MK01_HUMAN	PRGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
35	KSYK_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
36	MK01_HUMAN	SP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
37	MK08_HUMAN	NFAC4_HUMAN	kinase -> substrate	KEGG
38	MK08_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
39	FGR_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
40	MK01_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
41	KPCA_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
42	KPCA_HUMAN	GLI1_HUMAN	kinase -> substrate	KEGG
43	MK01_HUMAN	NR4A1_HUMAN	kinase -> substrate	HPRD
44	FGR_HUMAN	CSK21_HUMAN	kinase -> substrate	Robert H Newman (2013)
45	FGR_HUMAN	ENOA_HUMAN	kinase -> substrate	Robert H Newman (2013)
46	MK08_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
47	STA5A_HUMAN	IRF1_HUMAN	TF -> target gene	TRANSFAC
48	KPCA_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
49	KS6A2_HUMAN	NR4A1_HUMAN	kinase -> substrate	RegPhos
50	KS6A2_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
51	KS6B1_HUMAN	STK11_HUMAN	kinase -> substrate	HPRD
52	MK01_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
53	MK08_HUMAN	ELK3_HUMAN	kinase -> substrate	HPRD; RegPhos
54	MK01_HUMAN	MP2K1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
55	KS6B1_HUMAN	HSF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
56	KS6A2_HUMAN	SRF_HUMAN	kinase -> substrate	RegPhos
57	MK01_HUMAN	MITF_HUMAN	kinase -> substrate	NetPath
58	MK01_HUMAN	FOS_HUMAN	kinase -> substrate; other	KEGG
59	MK08_HUMAN	DYR1B_HUMAN	kinase -> substrate	Robert H Newman (2013)
60	MK08_HUMAN	NFAC2_HUMAN	kinase -> substrate	KEGG
61	HNRPK_HUMAN	MYC_HUMAN	TF -> target gene	TRANSFAC
62	KPCA_HUMAN	GSK3B_HUMAN	kinase -> substrate	KEGG; HPRD
63	MK01_HUMAN	ELK1_HUMAN	kinase -> substrate	NetPath
64	FGR_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
65	MK08_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
66	FGR_HUMAN	RXRA_HUMAN	kinase -> substrate	Robert H Newman (2013)
67	MK01_HUMAN	SOS1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
68	MK08_HUMAN	ATF2_HUMAN	kinase -> substrate	NetPath; Robert H Newman (2013)
69	MK01_HUMAN	SRBP2_HUMAN	kinase -> substrate	Robert H Newman (2013)
70	KS6A2_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
71	KS6A2_HUMAN	GABPA_HUMAN	kinase -> substrate	Robert H Newman (2013)
72	MK08_HUMAN	JUND_HUMAN	kinase -> substrate	KEGG
73	KS6A2_HUMAN	CSEN_HUMAN	kinase -> substrate	Robert H Newman (2013)
74	KPCA_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
75	MK01_HUMAN	MYB_HUMAN	kinase -> substrate	HPRD
76	MK08_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD; RegPhos
77	MK08_HUMAN	PPARA_HUMAN	kinase -> substrate	Robert H Newman (2013)
78	MK01_HUMAN	KS6A1_HUMAN	kinase -> substrate	HPRD
79	MK01_HUMAN	GCR_HUMAN	kinase -> substrate	HPRD
80	KS6A2_HUMAN	CREB1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
81	KPCA_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
82	KSYK_HUMAN	MK03_HUMAN	kinase -> substrate	NetPath
83	KS6A2_HUMAN	CEBPB_HUMAN	kinase -> substrate	RegPhos
84	MK01_HUMAN	ELK4_HUMAN	kinase -> substrate	KEGG
85	ITK_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
86	MK01_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
87	KPCA_HUMAN	MYOD1_HUMAN	kinase -> substrate	HPRD
88	MK08_HUMAN	MYC_HUMAN	kinase -> substrate	RegPhos
89	KPCA_HUMAN	AHR_HUMAN	kinase -> substrate	Robert H Newman (2013)
90	KPCA_HUMAN	EP300_HUMAN	kinase -> substrate	Robert H Newman (2013)
91	P53_HUMAN	P63_HUMAN	TF -> target gene	TRANSFAC
92	KPCA_HUMAN	KLF1_HUMAN	kinase -> substrate	HPRD
93	GTF2I_HUMAN	FOS_HUMAN	TF -> target gene	TRANSFAC
94	KPCA_HUMAN	FOS_HUMAN	kinase -> substrate	HPRD
95	MK08_HUMAN	MITF_HUMAN	kinase -> substrate	Robert H Newman (2013)
96	MK01_HUMAN	SRBP1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
97	KPCA_HUMAN	NFKB1_HUMAN	kinase -> substrate	HPRD
98	MK01_HUMAN	BCL6_HUMAN	kinase -> substrate	NetPath
99	KS6B1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
100	KPCA_HUMAN	GSK3A_HUMAN	kinase -> substrate	HPRD
101	P53_HUMAN	P73_HUMAN	TF -> target gene	KEGG; TRANSFAC
102	P53_HUMAN	ATF3_HUMAN	TF -> target gene	TRANSFAC
103	MK01_HUMAN	STF1_HUMAN	kinase -> substrate	HPRD
104	MK08_HUMAN	HSF1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
105	MK01_HUMAN	STK16_HUMAN	kinase -> substrate	Robert H Newman (2013)
106	MK08_HUMAN	JUN_HUMAN	kinase -> substrate; other	NetPath; Robert H Newman (2013); KEGG
107	KPCA_HUMAN	CREM_HUMAN	kinase -> substrate	HPRD
108	MK01_HUMAN	GSK3B_HUMAN	kinase -> substrate	Robert H Newman (2013)
109	KS6B1_HUMAN	MTOR_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
110	KPCA_HUMAN	RXRG_HUMAN	kinase -> substrate	Robert H Newman (2013)
111	MK08_HUMAN	FOXO4_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
112	P53_HUMAN	BBC3_HUMAN	TF -> target gene	TRANSFAC
113	MK01_HUMAN	THB_HUMAN	kinase -> substrate	Robert H Newman (2013)
114	MK01_HUMAN	RXRA_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
115	MK01_HUMAN	TF65_HUMAN	kinase -> substrate	Robert H Newman (2013)
116	SMAD3_HUMAN	JUN_HUMAN	TF -> target gene	TRANSFAC
117	KS6A2_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
118	MK08_HUMAN	FOS_HUMAN	kinase -> substrate	KEGG
119	MK01_HUMAN	JUN_HUMAN	kinase -> substrate	KEGG
120	MK08_HUMAN	PAX2_HUMAN	kinase -> substrate	NetPath
121	MK01_HUMAN	TFE2_HUMAN	kinase -> substrate	HPRD; NetPath
122	MK01_HUMAN	MYC_HUMAN	kinase -> substrate	KEGG; Robert H Newman (2013)
123	KS6A2_HUMAN	FOS_HUMAN	kinase -> substrate	RegPhos
124	MK01_HUMAN	PTN7_HUMAN	kinase -> substrate	HPRD
125	MK01_HUMAN	CEBPB_HUMAN	kinase -> substrate	HPRD
126	KPCA_HUMAN	ATF4_HUMAN	kinase -> substrate	KEGG
127	KS6B1_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
128	KPCA_HUMAN	TF65_HUMAN	kinase -> substrate	HPRD
129	KPCA_HUMAN	ATF1_HUMAN	kinase -> substrate	HPRD
130	KS6A2_HUMAN	KS6A1_HUMAN	kinase -> substrate	RegPhos
131	MK01_HUMAN	PPARA_HUMAN	kinase -> substrate	HPRD
132	MK01_HUMAN	SMAD4_HUMAN	kinase -> substrate	HPRD
133	FGR_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
134	KKCC1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
135	CHK2_HUMAN	E2F1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
136	ZAP70_HUMAN	MK14_HUMAN	kinase -> substrate	KEGG; RegPhos; Robert H Newman (2013)
137	KS6A1_HUMAN	ESR2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
138	ELK1_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
139	SP1_HUMAN	TGFR2_HUMAN	TF -> target gene	TRANSFAC
140	STK11_HUMAN	SIK1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
141	CSK21_HUMAN	MYF5_HUMAN	kinase -> substrate	HPRD
142	SP1_HUMAN	REL_HUMAN	TF -> target gene	TRANSFAC
143	SRF_HUMAN	EGR2_HUMAN	TF -> target gene	TRANSFAC
144	NR4A1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
145	STK11_HUMAN	SIK2_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
146	MP2K1_HUMAN	KS6A4_HUMAN	kinase -> substrate	RegPhos
147	CSK21_HUMAN	EGR1_HUMAN	kinase -> substrate	HPRD
148	STK11_HUMAN	TFE3_HUMAN	kinase -> substrate	Robert H Newman (2013)
149	CSK21_HUMAN	HMGA1_HUMAN	kinase -> substrate	HPRD
150	DYR1B_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
151	MYC_HUMAN	CDK4_HUMAN	TF -> target gene	TRANSFAC
152	GSK3B_HUMAN	CDX2_HUMAN	kinase -> substrate	RegPhos
153	CSK21_HUMAN	MAZ_HUMAN	kinase -> substrate	HPRD
154	SP1_HUMAN	RARA_HUMAN	TF -> target gene	TRANSFAC
155	RXRA_HUMAN	RARB_HUMAN	TF -> target gene	TRANSFAC
156	SP1_HUMAN	MAZ_HUMAN	TF -> target gene	TRANSFAC
157	PRGR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
158	DYR1B_HUMAN	HNF1A_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
159	PTN7_HUMAN	MK14_HUMAN	phosphatase -> substrate	KEGG
160	GCR_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
161	SP1_HUMAN	CDK2_HUMAN	TF -> target gene	TRANSFAC
162	CSK21_HUMAN	APEX1_HUMAN	kinase -> substrate	HPRD
163	SRF_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
164	CREB1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
165	MK03_HUMAN	MAZ_HUMAN	kinase -> substrate	Robert H Newman (2013)
166	CSK21_HUMAN	MEF2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
167	PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
168	SP1_HUMAN	AP2C_HUMAN	TF -> target gene	TRANSFAC
169	SP1_HUMAN	HNF4A_HUMAN	TF -> target gene	TRANSFAC
170	GSK3A_HUMAN	TF7L2_HUMAN	kinase -> substrate	Robert H Newman (2013)
171	STK11_HUMAN	SIK3_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
172	STK16_HUMAN	IRF5_HUMAN	kinase -> substrate	Robert H Newman (2013)
173	NFAC2_HUMAN	EGR3_HUMAN	TF -> target gene	TRANSFAC
174	CREB1_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
175	MTOR_HUMAN	HIF1A_HUMAN	kinase -> substrate	KEGG
176	SP1_HUMAN	SP3_HUMAN	TF -> target gene	TRANSFAC
177	FOXO4_HUMAN	IBP1_HUMAN	TF -> target gene	TRANSFAC
178	SP1_HUMAN	E2F1_HUMAN	TF -> target gene	TRANSFAC
179	CSK21_HUMAN	HIF1A_HUMAN	kinase -> substrate	HPRD
180	CSK21_HUMAN	MYF6_HUMAN	kinase -> substrate	Robert H Newman (2013)
181	CSK21_HUMAN	TF7L2_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
182	SP1_HUMAN	PHX2A_HUMAN	TF -> target gene	TRANSFAC
183	CSK21_HUMAN	NKX25_HUMAN	kinase -> substrate	HPRD
184	ATF1_HUMAN	EGR1_HUMAN	TF -> target gene	TRANSFAC
185	TGFR2_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
186	SIK1_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
187	SIK2_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
188	KS6A4_HUMAN	PO6F1_HUMAN	kinase -> substrate	Robert H Newman (2013)
189	PRDM1_HUMAN	PAX5_HUMAN	TF -> target gene	TRANSFAC
190	CDK4_HUMAN	FOXN2_HUMAN	kinase -> substrate	Robert H Newman (2013)
191	CDK2_HUMAN	NFYA_HUMAN	kinase -> substrate	HPRD
192	CDK4_HUMAN	PKNX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
193	SIK3_HUMAN	CRTC2_HUMAN	kinase -> substrate	HPRD
194	MEF2A_HUMAN	MYOG_HUMAN	TF -> target gene	TRANSFAC
195	CDK2_HUMAN	TFDP1_HUMAN	kinase -> substrate	RegPhos
196	5HT2C_HUMAN	GNA12_HUMAN	GPCR -> Gprotein	gpDB

⁺Protein attribute:

protein with cancer-related variations (CanProVar)

up expressed protein;

down expressed protein(dbDEPC)

protein with hyperphosphorylation site (PhosphoSitePlus)

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network