Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:5HT2C_HUMAN
Description:5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled [Source:HGNC Symbol;Acc:5295]
Location:chrX q23
Node attribute:receptor; GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S457SERISHPRD; phosphoELM
S456VSERIsHPRD; phosphoELM

Dephosphorylation site
5HT2C_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000361019L336VCOSMICOvarian Cancer21720365
ENSP00000276198P188LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000361019W55RCOSMICOvarian Cancer21720365
ENSP00000276198W55RCOSMICOvarian Cancer21720365
ENSP00000276198L336VCOSMICOvarian Cancer21720365
ENSP00000276198L336VTCGAOvarian Cancer21720365, 18772890
ENSP00000276198P393LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000276198Y382CBIOMARTBreast Cancer21930507, 21930502
ENSP00000361019P188LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000361019P393LTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000361019Y382CBIOMARTBreast Cancer21930507, 21930502
ENSP00000276198D42NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000361019L336VTCGAOvarian Cancer21720365, 18772890
ENSP00000276198W55RTCGAOvarian Cancer21720365, 18772890
ENSP00000361019W55RTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
5HT2C_HUMAN is not differential expressed protein.

Hyperphosphorylation site
5HT2C_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TPH1_HUMAN5HT2C_HUMANligand -> receptorHPMR
5HT2C_HUMANGNA12_HUMANGPCR -> GproteingpDB
5HT2C_HUMANGNAQ_HUMANGPCR -> GproteingpDB
5HT2C_HUMANGNA11_HUMANGPCR -> GproteingpDB
5HT2C_HUMANGNA13_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04020Calcium signaling pathway
hsa04726Serotonergic synapse
hsa04540Gap junction
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051209release of sequestered calcium ion into cytosolIMPbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIDAmolecular_function
GO:0006661phosphatidylinositol biosynthetic processIMPbiological_process
GO:0006182cGMP biosynthetic processIDAbiological_process
GO:0007631feeding behaviorTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0051378serotonin bindingIDAmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0070371ERK1 and ERK2 cascadeIMPbiological_process
GO:0004993serotonin receptor activityIDAmolecular_function
GO:0008144drug bindingIDAmolecular_function
GO:00718861-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine bindiIDAmolecular_function
GO:0007210serotonin receptor signaling pathwayIMPbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0042493response to drugIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0007268synaptic transmissionTASbiological_process


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