Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PK3CA_HUMAN
Description:phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha [Source:HGNC Symbol;Acc:8975]
Location:chr3 q26.32
Node attribute:effector; kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S312YSRRIsTATPYPhosphoSitePlus
T876QFNSHtLHQWLPI3_PI4_kinasePhosphoSitePlus
Y698RACGMyLKHLNPI3Ka; DUF2321PhosphoSitePlus
T315RISTAtPYMNGPhosphoSitePlus
T957VPFVLtQDFLIPI3_PI4_kinasePhosphoSitePlus
S874ALQFNsHTLHQPI3_PI4_kinasePhosphoSitePlus
S509AGFSYsHAGLSPhosphoSitePlus
Y584EVAQMyCLVKDPI3KaPhosphoSitePlus
S507REAGFsYSHAGPhosphoSitePlus
S332LWVINsALRIKPhosphoSitePlus
Y1038QEALEyFMKQMPhosphoSitePlus
Y294AKESLySQLPMPhosphoSitePlus
Y361VRTGIyHGGEPPI3K_C2PhosphoSitePlus
Y355DIDKIyVRTGIPI3K_C2PhosphoSitePlus
Y508EAGFSySHAGLPhosphoSitePlus
T313SRRIStATPYMPhosphoSitePlus
Y317STATPyMNGETPhosphoSitePlus
S306CFTMPsYSRRIPhosphoSitePlus
Y246LCVLEyQGKYIPI3K_rbdPhosphoSitePlus

Dephosphorylation site
PK3CA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263967F909LCOSMICIntestines Cancer17932254
ENSP00000263967A222VCOSMICUterine Cancer21266528
ENSP00000263967H1047LOMIMBreast Cancer15520168
ENSP00000263967A533VCOSMICBreast Cancer19027487
ENSP00000263967K1041NCOSMICThyroid Carcinoma16288007
ENSP00000263967A1020VCOSMICBreast Cancer21345071
ENSP00000263967M1010ICOSMICThyroid Carcinoma17317825
ENSP00000263967G1007RCOSMICLung Cancer20668451, 19962665
ENSP00000263967Q546PCOSMICIntestines Cancer17363507
ENSP00000263967D1029YCOSMICLung Cancer19394761
ENSP00000263967A1066VCOSMICOther Cancer
ENSP00000263967E707KCOSMICBreast Cancer19898424
ENSP00000263967A341VCOSMICHead and Neck Cancer19012001
ENSP00000263967I1058FCOSMICUterine Cancer21266528
ENSP00000263967I1019FCOSMICLymphoma19330652
ENSP00000263967H1047YHPIOther Cancer16322209
ENSP00000263967W552CCOSMICIntestines Cancer21351276
ENSP00000263967E982KCOSMICThyroid Carcinoma16288007
ENSP00000263967M1004ICOSMICUterine Cancer21266528
ENSP00000263967S1015FCOSMICOvarian Cancer19638206
ENSP00000263967I311VCOSMICNeoplasms by Histologic Type21225506
ENSP00000263967F550SCOSMICThyroid Carcinoma17317825
ENSP00000263967Q530RCOSMICOvarian Cancer19638206
ENSP00000263967G1009ECOSMICThyroid Carcinoma16288007
ENSP00000263967K986NCOSMICIntestines Cancer19962665
ENSP00000263967P124LCOSMICOther Cancer
ENSP00000263967E110KCOSMICBreast Cancer15254419
ENSP00000263967R349*COSMICHead and Neck Cancer19012001
ENSP00000263967E453delCOSMICIntestines Cancer20049837
ENSP00000263967K111ECOSMICOvarian Cancer19349352
ENSP00000263967Y343CCOSMICHead and Neck Cancer16533766
ENSP00000263967L866FBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000263967H1047RCOSMICOther Cancer21533174
ENSP00000263967E39KCOSMICOvarian Cancer19349352
ENSP00000263967E726KCOSMICIntestines Cancer19962665
ENSP00000263967Y1021NHPIOther Cancer15289301
ENSP00000263967D1018NCOSMICThyroid Carcinoma17426084
ENSP00000263967H1047LCOSMICHead and Neck Cancer21798893
ENSP00000263967R93QCOSMICUterine Cancer21266528
ENSP00000263967K733RCOSMICIntestines Cancer15520168
ENSP00000263967F667LCOSMICUterine Cancer21266528
ENSP00000263967G106VHPIOther Cancer15930273 21266528
ENSP00000263967T1025ACOSMICLung Cancer
ENSP00000263967C420RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000263967A987TCOSMICIntestines Cancer18193083
ENSP00000263967E1012KCOSMICBreast Cancer19706770
ENSP00000263967D1017HCOSMICOther Cancer21533174
ENSP00000263967G364RCOSMICUterine Cancer21266528
ENSP00000263967E970KCOSMICBreast Cancer20668451
ENSP00000263967R1023QHPIOther Cancer15994075
ENSP00000263967S405FCOSMICBreast Cancer15520168
ENSP00000263967Q75ECOSMICCentral Nervous System Neoplasms18772396
ENSP00000263967E542KCOSMICCentral Nervous System Neoplasms17050665
ENSP00000263967P539RCOSMICCentral Nervous System Neoplasms18772890
ENSP00000263967E970KCOSMICBreast Cancer20668451
ENSP00000263967Q60KCOSMICBreast Cancer15805248
ENSP00000263967N515SCOSMICGastric Cancer20937558
ENSP00000263967P18LDing2008, COSMICLung Cancer18948947
ENSP00000263967R310CCOSMICCentral Nervous System Neoplasms17050665
ENSP00000263967K1024RCOSMICOvarian Cancer19349352
ENSP00000263967A1035VCOSMICUterine Cancer16322209
ENSP00000263967L531PCOSMICBreast Cancer19844788
ENSP00000263967L1026PCOSMICLymphoma17657213
ENSP00000263967Q546EOMIMBreast Cancer15520168
ENSP00000263967R88QTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263967Y343CHPIOther Cancer16533766
ENSP00000263967E1037KCOSMICOvarian Cancer19349352
ENSP00000263967M1043VCOSMICBreast Cancer20668451
ENSP00000263967E80KBIOMARTBreast Cancer21930507, 21930502
ENSP00000263967G1049ATCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263967L1036SCOSMICUterine Cancer17471559
ENSP00000263967G1049SCOSMICOther Cancer21533174
ENSP00000263967E545KCOSMICOther Cancer19789314
ENSP00000263967H1047RTCGAOvarian Cancer21720365, 18772890
ENSP00000263967T1052KCOSMICLung Cancer19394761
ENSP00000263967M1040LCOSMICUterine Cancer21266528
ENSP00000263967F1059LCOSMICBiliary Tract Cancer21087480
ENSP00000263967V344GCOSMICCentral Nervous System Neoplasms17050665
ENSP00000263967G12DCOSMICLung Cancer19962665
ENSP00000263967W1057*COSMICBreast Cancer19027487
ENSP00000263967E542VHPIOther Cancer16353168
ENSP00000263967C901FCOSMICIntestines Cancer17932254
ENSP00000263967D1045NCOSMICIntestines Cancer18516290
ENSP00000263967H701PCOSMICCentral Nervous System Neoplasms15016963
ENSP00000263967G1049RBIOMARTBreast Cancer21930507, 21930502
ENSP00000263967K111NBIOMARTBreast Cancer21930507, 21930502
ENSP00000263967D1056NCOSMICGastric Cancer20398348
ENSP00000263967E545KCOSMICCentral Nervous System Neoplasms21817013
ENSP00000263967H1048TCOSMICGastric Cancer20398348
ENSP00000263967A1035VHPIOther Cancer16322209
ENSP00000263967R524MCOSMICNeoplasms by Histologic Type16822308
ENSP00000263967R108HBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000263967L339FCOSMICEsophageal Cancer16380997
ENSP00000263967T324ICOSMICPancreatic Cancer18343945
ENSP00000263967T1031ICOSMICThyroid Carcinoma16288007
ENSP00000263967E418KCOSMICBreast Cancer15805248
ENSP00000263967E525KCOSMICBreast Cancer19844788
ENSP00000263967R1023QCOSMICIntestines Cancer
ENSP00000263967H1065YCOSMICCentral Nervous System Neoplasms15289301
ENSP00000263967L719VCOSMICBreast Cancer19898424
ENSP00000263967M1043ICOSMICOvarian Cancer19349352
ENSP00000263967I543VCOSMICLymphoma17657213
ENSP00000263967N457KCOSMICBreast Cancer19844788
ENSP00000263967M1043IHPIOther Cancer15930273 16322209 22120714
ENSP00000263967Q643RCOSMICOther Cancer19789314
ENSP00000263967C407WCOSMICOvarian Cancer20826764
ENSP00000263967G122DCOSMICIntestines Cancer15016963
ENSP00000263967C420RTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263967P1011SCOSMICGastric Cancer15608678
ENSP00000263967R38HHPIOther Cancer15930273 16339315
ENSP00000263967I1062VCOSMICBreast Cancer19027487
ENSP00000263967I112NCOSMICUterine Cancer17471559
ENSP00000263967M1040TBIOMARTBreast Cancer21930507, 21930502
ENSP00000263967E545AHPIOther Cancer15924253 15608678 22026810 19584164 18382359 18317450 18221484
ENSP00000263967R115LCOSMICHead and Neck Cancer21798893
ENSP00000263967D133VCOSMICHepatocellular Carcinoma17187432
ENSP00000263967L523SCOSMICBreast Cancer19844788
ENSP00000263967Q546KBIOMARTBreast Cancer21930507, 21930502
ENSP00000263967E545KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263967K594ECOSMICIntestines Cancer19962665
ENSP00000263967P134SCOSMICIntestines Cancer18224685
ENSP00000263967E81KCOSMICUterine Cancer21266528
ENSP00000263967K567RCOSMICBreast Cancer19593635
ENSP00000263967A1046VCOSMICBreast Cancer15254419
ENSP00000263967S1008PCOSMICIntestines Cancer15016963
ENSP00000263967K179TCOSMICIntestines Cancer18224685
ENSP00000263967I20MCOSMICUterine Cancer21984976
ENSP00000263967D520NCOSMICThyroid Carcinoma17317825
ENSP00000263967N345KCOSMICCentral Nervous System Neoplasms21817013
ENSP00000263967G1007RHPIOther Cancer16322209
ENSP00000263967Y1021CCOSMICOvarian Cancer19349352
ENSP00000263967D538GCOSMICThyroid Carcinoma17317825
ENSP00000263967P471LCOSMICSkin Cancer21984974
ENSP00000263967P104LBIOMARTBreast Cancer21930507, 21930502
ENSP00000263967G1050DHPIOther Cancer16322209
ENSP00000263967P471LCOSMICSkin Cancer21984974
ENSP00000263967R88QCOSMICCentral Nervous System Neoplasms18772890
ENSP00000263967E542KCOSMICHead and Neck Cancer21798893
ENSP00000263967L1001HCOSMICThyroid Carcinoma17426084
ENSP00000263967T1025NHPIOther Cancer15924253
ENSP00000263967E453QHPIOther Cancer15930273
ENSP00000263967S553NCOSMICThyroid Carcinoma17317825
ENSP00000263967N345KCOSMICBreast Cancer18676830
ENSP00000263967H1065YHPIOther Cancer15289301
ENSP00000263967D549NCOSMICIntestines Cancer16376301
ENSP00000263967E522KCOSMICThyroid Carcinoma16288007
ENSP00000263967G106VCOSMICIntestines Cancer15016963
ENSP00000263967L866WCOSMICGastric Cancer19962665
ENSP00000263967E365KCOSMICUterine Cancer21266528
ENSP00000263967T1053ICOSMICGastric Cancer20398348
ENSP00000263967P421LCOSMICIntestines Cancer20049837
ENSP00000263967P104RCOSMICIntestines Cancer15016963
ENSP00000263967S158LCOSMICIntestines Cancer18224685
ENSP00000263967R38HCOSMICIntestines Cancer15016963
ENSP00000263967R108PCOSMICIntestines Cancer15016963
ENSP00000263967F1016LCOSMICThyroid Carcinoma17426084
ENSP00000263967P449TCOSMICIntestines Cancer17088437
ENSP00000263967E1034GCOSMICHepatocellular Carcinoma15608678
ENSP00000263967W552*COSMICIntestines Cancer19731079
ENSP00000263967I31MCOSMICBreast Cancer17669465
ENSP00000263967P298TCOSMICCentral Nervous System Neoplasms17050665
ENSP00000263967W1051*COSMICOvarian Cancer19349352
ENSP00000263967D350HCOSMICCentral Nervous System Neoplasms15016963
ENSP00000263967Q661KCOSMICIntestines Cancer15016963
ENSP00000263967S173YCOSMICIntestines Cancer18224685
ENSP00000263967N1044KCOSMICOvarian Cancer21435433
ENSP00000263967Q546RHPIOther Cancer16353168
ENSP00000263967E453KCOSMICCentral Nervous System Neoplasms17050665
ENSP00000263967C420RHPIOther Cancer15930273 22120714
ENSP00000263967P17SCOSMICIntestines Cancer18224685
ENSP00000263967K1030ECOSMICThyroid Carcinoma16288007
ENSP00000263967G1050DCOSMICUterine Cancer16322209
ENSP00000263967C378RCOSMICIntestines Cancer17363507
ENSP00000263967K184ECOSMICIntestines Cancer18224685
ENSP00000263967N521SCOSMICThyroid Carcinoma17317825
ENSP00000263967L989ICOSMICUterine Cancer19839777
ENSP00000263967H160NCOSMICIntestines Cancer18224685
ENSP00000263967N345KTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263967L1067FCOSMICGastric Cancer20398348
ENSP00000263967G118DCOSMICLung Cancer
ENSP00000263967Y1038CCOSMICIntestines Cancer18224685
ENSP00000263967T1052KHPIOther Cancer16322209
ENSP00000263967F1039LCOSMICThyroid Carcinoma17317825
ENSP00000263967P539RTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000263967R88QHPIOther Cancer15924253
ENSP00000263967E545AOMIMHepatocellular Carcinoma15608678
ENSP00000263967E547KCOSMICBreast Cancer19027487

Differential expressed protein
PK3CA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PK3CA_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GNAQ_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG2_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG10_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG5_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG13_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG1_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBB5_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG12_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBB3_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBB1_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBB2_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG11_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG3_HUMANPK3CA_HUMANGprotein -> effectorgpDB
GBG8_HUMANPK3CA_HUMANGprotein -> effectorgpDB
PK3CA_HUMANP85A_HUMANkinase -> substrateRegPhos
PK3CA_HUMANKS6B1_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05160Hepatitis C
hsa05211Renal cell carcinoma
hsa05212Pancreatic cancer
hsa04650Natural killer cell mediated cytotoxicity
hsa05146Amoebiasis
hsa05222Small cell lung cancer
hsa04630Jak-STAT signaling pathway
hsa05164Influenza A
hsa04910Insulin signaling pathway
hsa04660T cell receptor signaling pathway
hsa05169Epstein-Barr virus infection
hsa04070Phosphatidylinositol signaling system
hsa04914Progesterone-mediated oocyte maturation
hsa04722Neurotrophin signaling pathway
hsa05203Viral carcinogenesis
hsa00562Inositol phosphate metabolism
hsa04664Fc epsilon RI signaling pathway
hsa05213Endometrial cancer
hsa04370VEGF signaling pathway
hsa04930Type II diabetes mellitus
hsa05210Colorectal cancer
hsa04062Chemokine signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa04725Cholinergic synapse
hsa05166HTLV-I infection
hsa05223Non-small cell lung cancer
hsa04620Toll-like receptor signaling pathway
hsa04150mTOR signaling pathway
hsa05145Toxoplasmosis
hsa04210Apoptosis
hsa04380Osteoclast differentiation
hsa05218Melanoma
hsa04662B cell receptor signaling pathway
hsa04670Leukocyte transendothelial migration
hsa04973Carbohydrate digestion and absorption
hsa05100Bacterial invasion of epithelial cells
hsa05200Pathways in cancer
hsa05215Prostate cancer
hsa05162Measles
hsa04510Focal adhesion
hsa05220Chronic myeloid leukemia
hsa04960Aldosterone-regulated sodium reabsorption
hsa05221Acute myeloid leukemia
hsa04810Regulation of actin cytoskeleton
hsa05214Glioma
hsa04012ErbB signaling pathway
hsa04666Fc gamma R-mediated phagocytosis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030168platelet activationTASbiological_process
GO:0038028insulin receptor signaling pathway via phosphatidyTASbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0046854phosphatidylinositol phosphorylationISSbiological_process
GO:0060048cardiac muscle contractionTASbiological_process
GO:0030027lamellipodiumIEAcellular_component
GO:2000811negative regulation of anoikisIMPbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0001944vasculature developmentTASbiological_process
GO:0044029hypomethylation of CpG islandIEAbiological_process
GO:0016773phosphotransferase activity, alcohol group as acceIEAmolecular_function
GO:0045860positive regulation of protein kinase activityIEAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0036092phosphatidylinositol-3-phosphate biosynthetic procIDAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:00163031-phosphatidylinositol-3-kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIEAbiological_process
GO:0043542endothelial cell migrationTASbiological_process
GO:0006661phosphatidylinositol biosynthetic processTASbiological_process
GO:0006644phospholipid metabolic processTASbiological_process
GO:0030295protein kinase activator activityIEAmolecular_function
GO:0006006glucose metabolic processIEAbiological_process
GO:2000653regulation of genetic imprintingIEAbiological_process
GO:0040014regulation of multicellular organism growthIEAbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:00059431-phosphatidylinositol-4-phosphate 3-kinase, classIDAcellular_component
GO:0035004phosphatidylinositol 3-kinase activityISSmolecular_function
GO:0005829cytosolTAScellular_component
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase actTASmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0005942phosphatidylinositol 3-kinase complexIEAcellular_component
GO:0050852T cell receptor signaling pathwayTASbiological_process
GO:0031295T cell costimulationTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0044281small molecule metabolic processTASbiological_process
GO:0050900leukocyte migrationTASbiological_process
GO:0016301kinase activityTASmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0033138positive regulation of peptidyl-serine phosphorylaIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0043560insulin receptor substrate bindingIEAmolecular_function