Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:KS6B1_HUMAN
Description:ribosomal protein S6 kinase, 70kDa, polypeptide 1 [Source:HGNC Symbol;Acc:10436]
Location:chr17 q23.1
Node attribute:substrate; kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T412VFLGFtYVAPSHPRD; phosphoELM
S394QTPVDsPDDSTCDC2(CDK1RegPhos
S434EPKIRsPRRFICDC2RegPhos
T250HDGTVtHTFCGPkinasePhosphoSitePlus
T412VFLGFtYVAPSmTORphosphoELM
S403STLSEsANQVFPkinase_CPhosphoSitePlus
T252GTVTHtFCGTIPDPK1HPRD
S427VKEKFsFEPKIPDK-1phosphoELM
T444IGSPRtPVSPVCDC2(CDK1RegPhos
T444IGSPRtPVSPVFRAP(mTORRegPhos
T390KFTRQtPVDSPHPRD; phosphoELM; RegPhos
S434EPKIRsPRRFImTORphosphoELM
T252GTVTHtFCGTIPDK1RegPhos
T412VFLGFtYVAPSPDK-1phosphoELM
S447PRTPVsPVKFSFRAP(mTORRegPhos; SysPTM
T390KFTRQtPVDSPFRAP(mTORRegPhos
S434EPKIRsPRRFICDK1HPRD; phosphoELM
T412VFLGFtYVAPSPDK1RegPhos
T412VFLGFtYVAPSp70S6KphosphoELM; RegPhos
S427VKEKFsFEPKIPDK1RegPhos
T252GTVTHtFCGTIPDK-1phosphoELM
S398DSPDDsTLSESHPRD
T252GTVTHtFCGTIPkinasePhosphoSitePlus
S394QTPVDsPDDSTPkinase_CPhosphoSitePlus
S434EPKIRsPRRFICDC2(CDK1RegPhos
S421PSVLEsVKEKFPhosphoSitePlus
T444IGSPRtPVSPVCDK1phosphoELM
Y413FLGFTyVAPSVPkinase_CPhosphoSitePlus
S394QTPVDsPDDSTFRAP(mTORRegPhos
T470TANPQtPVEYPPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T444IGSPRtPVSPVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S394QTPVDsPDDSTMTORHPRD
S394QTPVDsPDDSTphosphoELM
S441RRFIGsPRTPVPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T248SIHDGtVTHTFPkinasePhosphoSitePlus
S447PRTPVsPVKFSCDK1phosphoELM; SysPTM
S427VKEKFsFEPKIPhosphoSitePlus; HPRD; RegPhos
T412VFLGFtYVAPSMTORHPRD
S447PRTPVsPVKFSCDC2(CDK1RegPhos; SysPTM
S434EPKIRsPRRFIFRAP(mTORRegPhos
S394QTPVDsPDDSTCDC2RegPhos
S53GQLNEsMDHGGPhosphoSitePlus; phosphoELM
S434EPKIRsPRRFIPhosphoSitePlus; phosphoELM
S447PRTPVsPVKFSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S394QTPVDsPDDSTFRAPRegPhos
S243GLCKEsIHDGTPkinasePhosphoSitePlus
T412VFLGFtYVAPSFRAP(mTORRegPhos
T412VFLGFtYVAPSPkinase_CPhosphoSitePlus
S403STLSEsANQVFphosphoELM
T390KFTRQtPVDSPPDK1HPRD; RegPhos
T390KFTRQtPVDSPPIK3CAHPRD
S394QTPVDsPDDSTCDK1HPRD; phosphoELM
T390KFTRQtPVDSPPkinase_CPhosphoSitePlus
S394QTPVDsPDDSTmTORphosphoELM
S447PRTPVsPVKFSmTORphosphoELM; SysPTM
T256HTFCGtIEYMAPkinasePhosphoSitePlus
T390KFTRQtPVDSPmTORphosphoELM
S452SPVKFsPGDFWPhosphoSitePlus; HPRD; phosphoELM
T412VFLGFtYVAPSPDPK1HPRD
T390KFTRQtPVDSPMTORHPRD

Dephosphorylation site
KS6B1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000225577G289EBIOMART, HPIColorectal Cancer21930507, 21930502, 16959974
ENSP00000225577I264VBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000225577G289ESjoblom2006Intestines Cancer16959974, 21930507, 21930502

Differential expressed protein
KS6B1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
T412Pkinase_CNQVFLGFtYVAPSVLtype 2 diabetes17709744PhosphoSitePlus
T412Pkinase_CNQVFLGFtYVAPSVLovarian epithelial carcinoma21276607PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
KS6B1_HUMANNFAC4_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANHSF1_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANMTOR_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KS6B1_HUMANMDM2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANSYNJ2_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANKS6B1_HUMANkinase -> substrateRegPhos
KS6B1_HUMANRS6_HUMANkinase -> substrateNetPath
KS6B1_HUMANFGR_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANPP1R8_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANFR1OP_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANIRF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANHCLS1_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANNCBP2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANIF4B_HUMANkinase -> substrateKEGG; HPRD; Robert H Newman (2013)
KS6B1_HUMANHNRPK_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANKPCA_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANSRXN1_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANIRS1_HUMANkinase -> substrateKEGG; NetPath
KS6B1_HUMANTRIP6_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANSAFB2_HUMANkinase -> substrateRobert H Newman (2013)
MTOR_HUMANKS6B1_HUMANkinase -> substrateRegPhos
KS6B1_HUMAN4ET_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANASAP2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANASAP3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANSMCE1_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANCDA7L_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANPHB2_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANNXF3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANARI3A_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANPDIP3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANNFAC3_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMAN1433E_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANZN363_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANTAU_HUMANkinase -> substrateHPRD
KS6B1_HUMANRAB5B_HUMANkinase -> substrateRobert H Newman (2013)
CDK1_HUMANKS6B1_HUMANkinase -> substrateRegPhos
KS6B1_HUMANSRC8_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANENC2_HUMANkinase -> substrateRobert H Newman (2013)
PK3CA_HUMANKS6B1_HUMANkinase -> substrateHPRD
KS6B1_HUMANBAX_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANKS6B1_HUMANkinase -> substrateRegPhos
KS6B1_HUMANSTK11_HUMANkinase -> substrateHPRD
KS6B1_HUMANEF2K_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
KS6B1_HUMANNAR4_HUMANkinase -> substrateRobert H Newman (2013)
KS6B1_HUMANBPL1_HUMANkinase -> substrateRobert H Newman (2013)
PP2AA_HUMANKS6B1_HUMANphosphatase -> substrateKEGG
KS6B1_HUMANRS6_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04350TGF-beta signaling pathway
hsa05221Acute myeloid leukemia
hsa04910Insulin signaling pathway
hsa04012ErbB signaling pathway
hsa04666Fc gamma R-mediated phagocytosis
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0005840ribosomeIEAcellular_component
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0043491protein kinase B signaling cascadeIEAbiological_process
GO:0045931positive regulation of mitotic cell cycleIMPbiological_process
GO:0045727positive regulation of translationIMPbiological_process
GO:0043005neuron projectionIEAcellular_component
GO:0046324regulation of glucose importIEAbiological_process
GO:0009408response to heatIEAbiological_process
GO:0042277peptide bindingIEAmolecular_function
GO:0014878response to electrical stimulus involved in regulaIEAbiological_process
GO:0007584response to nutrientIEAbiological_process
GO:0033574response to testosterone stimulusIEAbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0014732skeletal muscle atrophyIEAbiological_process
GO:0043201response to leucineIEAbiological_process
GO:0048661positive regulation of smooth muscle cell proliferIEAbiological_process
GO:0042493response to drugIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0006468protein phosphorylationIDAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0045948positive regulation of translational initiationIMPbiological_process
GO:0045202synapseIEAcellular_component
GO:0006915apoptotic processIEAbiological_process
GO:0071363cellular response to growth factor stimulusIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0009986cell surfaceIEAcellular_component
GO:0033762response to glucagon stimulusIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0000082G1/S transition of mitotic cell cycleIMPbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0009636response to toxinIEAbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0007568agingIEAbiological_process
GO:0014911positive regulation of smooth muscle cell migratioIEAbiological_process
GO:0048471perinuclear region of cytoplasmIEAcellular_component
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0016477cell migrationIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0043434response to peptide hormone stimulusIEAbiological_process
GO:0003009skeletal muscle contractionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0046627negative regulation of insulin receptor signaling IEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0007165signal transductionTASbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0032870cellular response to hormone stimulusIEAbiological_process
GO:0009611response to woundingIEAbiological_process
GO:0031929TOR signaling cascadeIDAbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0004711ribosomal protein S6 kinase activityIEAmolecular_function
GO:0032868response to insulin stimulusIEAbiological_process
GO:0048633positive regulation of skeletal muscle tissue growIEAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0010033response to organic substanceIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0034612response to tumor necrosis factorIEAbiological_process
GO:0009612response to mechanical stimulusIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0007281germ cell developmentIEAbiological_process