Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	PKN1_HUMAN
Description:	protein kinase N1 [Source:HGNC Symbol;Acc:9405]
Location:	chr19 p13.12
Node attribute:	PPI(source); substrate; kinase; PPI(target)

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
T527	LIPNAtGTGTF		PhosphoSitePlus
T353	MGGPGtPDSRP		PhosphoSitePlus; HPRD
S614	SPLRKsPLTLE	PKN1	HPRD
S537	FSPGAsPGSEA		PhosphoSitePlus; HPRD; phosphoELM
T772	GYGDRtSTFCG		HPRD
S908	GRTDVsNFDEE		HPRD
S902	GRTDVsNFDEE	Pkinase_C	PhosphoSitePlus
S565	NLGTDsDSSPQ		HPRD
T780	GDRTStFCGTP	PDPK1	HPRD
S380	LSGRSsLKAEA	PKN1	HPRD; RegPhos
S374	YSRSGsLSGRS	PKN1	HPRD; RegPhos
S568	TDSDSsPQKSS		HPRD
S372	GLYSRsGSLSG	PKN1	HPRD; RegPhos
T64	LRRATtDLGRS	HR1	PhosphoSitePlus
S378	GLYSRsGSLSG	PKN1	HPRD
S916	EAPTLsPPRDA		HPRD; phosphoELM; RegPhos
T70	LRRATtDLGRS	PKN1	HPRD
T315	ATHYStLCKPA		PhosphoSitePlus
S582	PSSPSsLSSPI	PKN1	HPRD
T557	KLNLGtDSDSS		PhosphoSitePlus; HPRD
S575	PPSSPsSLSSP		PhosphoSitePlus
T772	GYGDRtSTFCG	Pkinase	PhosphoSitePlus
T537	ATGTGtFSPGA	PKN1	HPRD
S567	GTDSDsSPQKS		HPRD
T914	TGEAPtLSPPR		HPRD
T64	LRRATtDLGRS	PKN1	HPRD; RegPhos
T774	GDRTStFCGTP		phosphoELM; RegPhos
S372	GLYSRsGSLSG		PhosphoSitePlus
S240	VLRLLsAAKAP		HPRD
T925	DARPLtAAEQA	Pkinase_C	PhosphoSitePlus
T63	NLRRAtTDLGR	HR1	PhosphoSitePlus
S561	GTDSDsSPQKS		PhosphoSitePlus; HPRD
T784	STFCGtPEFLA		HPRD
T563	KLNLGtDSDSS		HPRD
T774	GDRTStFCGTP	PDK1	RegPhos
S205	DDTQGsPDLGA		PhosphoSitePlus; HPRD
S301	SSAAFsTRLAG		PhosphoSitePlus
T529	PNATGtGTFSP		PhosphoSitePlus
S916	EAPTLsPPRDA	Pkinase_C	PhosphoSitePlus
T774	GDRTStFCGTP	PDPK1	HPRD
T359	MGGPGtPDSRP		HPRD
S559	NLGTDsDSSPQ		PhosphoSitePlus; HPRD; phosphoELM
T778	STFCGtPEFLA		HPRD; phosphoELM
S382	RSGSLsGRSSL		HPRD
Y768	KEGMGyGDRTS	Pkinase	PhosphoSitePlus
S380	YSRSGsLSGRS	PKN1	HPRD
S608	SPLRKsPLTLE	PKN1	HPRD; RegPhos
S773	YGDRTsTFCGT	Pkinase	PhosphoSitePlus
T914	TGEAPtLSPPR	Pkinase_C	PhosphoSitePlus
S240	VLRLLsAAKAP	HR1	PhosphoSitePlus
T774	GDRTStFCGTP	PDK-1	phosphoELM
S69	TDLGRsLGPVE	HR1	PhosphoSitePlus
S902	GRTDVsNFDEE		HPRD
S539	GTGTFsPGASP		HPRD
S3	___MAsDAVQS		PhosphoSitePlus
S543	FSPGAsPGSEA		HPRD
S576	PSSPSsLSSPI	PKN1	HPRD; RegPhos
S562	TDSDSsPQKSS		PhosphoSitePlus; HPRD; phosphoELM; RegPhos
T778	GYGDRtSTFCG		HPRD
T531	ATGTGtFSPGA	PKN1	HPRD; RegPhos
S112	HDGPQsPGAGG		PhosphoSitePlus
S922	EAPTLsPPRDA		HPRD
S374	YSRSGsLSGRS		PhosphoSitePlus
T920	TGEAPtLSPPR		HPRD
S576	PSSPSsLSSPI		PhosphoSitePlus
S246	VLRLLsAAKAP		HPRD
S380	LSGRSsLKAEA		PhosphoSitePlus
T778	STFCGtPEFLA	Pkinase	PhosphoSitePlus
T774	GDRTStFCGTP	Pkinase	PhosphoSitePlus
T611	RKSPLtLEDFK		PhosphoSitePlus
S211	DDTQGsPDLGA		HPRD
S533	GTGTFsPGASP		PhosphoSitePlus; HPRD; phosphoELM
S376	RSGSLsGRSSL		HPRD; phosphoELM; RegPhos

Dephosphorylation site

PKN1_HUMAN do not have dephosphorylation site.

Mutation site

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000242783	R185C	Greenman2007	Skin Cancer	17344846, 18428421, 21930507, 21930502
ENSP00000242783	F873L	Greenman2007	Breast Cancer	15908952, 17344846, 18428421
ENSP00000242783	E764D	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000242783	A921V	HPI	Colorectal Cancer	17344846
ENSP00000242783	F873L	HPI	breast ductal carcinoma	17344846
ENSP00000242783	R185C	BIOMART	Melanoma	21930507, 21930502
ENSP00000242783	E327G	TCGA	Ovarian Cancer	21720365, 18772890
ENSP00000242783	A921V	Greenman2007	Intestines Cancer	17344846, 18428421

Differential expressed protein

PKN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site

PKN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
CDK5_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; RegPhos
PKN1_HUMAN	MAGA9_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	LIMK1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
PKN1_HUMAN	KC1G2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	FLNA_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	MPIP3_HUMAN	kinase -> substrate	HPRD; RegPhos
PKN1_HUMAN	PRI2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	KPCA_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	HNRPK_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ZHX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	IF4H_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MK12_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	SNAI1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	BPL1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	WIPI3_HUMAN	kinase -> substrate	Robert H Newman (2013)
ZAGL2_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
PKN1_HUMAN	MP2K1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
PKN1_HUMAN	CXXC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	STMN1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	MDM4_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	CSAG2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	KCIP4_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	IF4A3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ZDH11_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	BRAF_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos
PKN1_HUMAN	VIME_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	TB22A_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	IF4B_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	SYN1_HUMAN	kinase -> substrate	HPRD; RegPhos
PKN1_HUMAN	FOXN3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MEN1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	OTU7B_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	IASPP_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	RHG20_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	PGM1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	ESR1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
PKN1_HUMAN	ARC1B_HUMAN	kinase -> substrate	HPRD; RegPhos
PKN1_HUMAN	EXOS5_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ABI2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	TAK1L_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	1433F_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	SRC8_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MDFI_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MAX_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	BPNT1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	NACC2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ZN396_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MYLK_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
PKN1_HUMAN	FOXL2_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
PKN1_HUMAN	MBNL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ARRD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MTG8_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	DAXX_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	PHB2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	TBCB_HUMAN	kinase -> substrate	RegPhos
PKN1_HUMAN	ARHG2_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
PKN1_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	TRI16_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ASAP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	PGAM1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	MTA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ZCHC8_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	BAD_HUMAN	kinase -> substrate	HPRD
PKN1_HUMAN	MERL_HUMAN	kinase -> substrate	HPRD; RegPhos
PDPK1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
PKN1_HUMAN	MARCS_HUMAN	kinase -> substrate	RegPhos
OXSR1_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; RegPhos
PKN1_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	CASP1_HUMAN	kinase -> substrate	HPRD
PKN1_HUMAN	2AAA_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	RUVB2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	FOXO1_HUMAN	kinase -> substrate	HPRD; RegPhos
PKN1_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	GNAZ_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	MAGA2_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	GDIR1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	RAF1_HUMAN	kinase -> substrate	RegPhos; Robert H Newman (2013)
PKN1_HUMAN	PKN1_HUMAN	kinase -> substrate	RegPhos
PKN1_HUMAN	GRK5_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	SRSF1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	LRIG1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	HCLS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	MP2K4_HUMAN	kinase -> substrate	KEGG
PKN1_HUMAN	CSRP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	BCL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	M3K2_HUMAN	kinase -> substrate	KEGG
PKN1_HUMAN	STK16_HUMAN	kinase -> substrate	Robert H Newman (2013)
MK01_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
PKN1_HUMAN	MYOD1_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	2A5D_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	ZBT44_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	UPK3A_HUMAN	kinase -> substrate	Robert H Newman (2013)
PKN1_HUMAN	M3K14_HUMAN	other	KEGG
RAC1_HUMAN	PKN1_HUMAN	other	KEGG
CASP3_HUMAN	PKN1_HUMAN	other	KEGG

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05132	Salmonella infection

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0035402	histone kinase activity (H3-T11 specific)	IDA	molecular_function
GO:0042393	histone binding	IDA	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0006357	regulation of transcription from RNA polymerase II	IDA	biological_process
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0032154	cleavage furrow	IDA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	cellular_component
GO:0030496	midbody	IDA	cellular_component
GO:0005080	protein kinase C binding	IPI	molecular_function
GO:0006351	transcription, DNA-dependent	IEA	biological_process
GO:0030374	ligand-dependent nuclear receptor transcription co	IDA	molecular_function
GO:0042826	histone deacetylase binding	IDA	molecular_function
GO:0007165	signal transduction	TAS	biological_process
GO:0004674	protein serine/threonine kinase activity	IDA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0006972	hyperosmotic response	IEA	biological_process
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0050681	androgen receptor binding	IDA	molecular_function
GO:2000145	regulation of cell motility	IMP	biological_process
GO:0006468	protein phosphorylation	IDA	biological_process
GO:0005768	endosome	IDA	cellular_component
GO:0003682	chromatin binding	IDA	molecular_function
GO:0035407	histone H3-T11 phosphorylation	IDA	biological_process
GO:0007257	activation of JUN kinase activity	TAS	biological_process
GO:0010631	epithelial cell migration	IMP	biological_process
GO:0004697	protein kinase C activity	IEA	molecular_function
GO:0048365	Rac GTPase binding	IDA	molecular_function
GO:0017049	GTP-Rho binding	IDA	molecular_function
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network