Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SOX10_HUMAN
Description:SRY (sex determining region Y)-box 10 [Source:HGNC Symbol;Acc:11190]
Location:chr22 q13.1
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S45SGLRAsPGPGEPhosphoSitePlus
Y171KDHPDyKYQPRHMG_boxPhosphoSitePlus
S24EPRCLsPGSAPPhosphoSitePlus

Dephosphorylation site
SOX10_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000380093Q125*COSMICMelanoma19422606
ENSP00000354130A361VCOSMICMelanoma19422606
ENSP00000354130H414YCOSMICMelanoma19422606
ENSP00000380093A424VCOSMICMelanoma19422606
ENSP00000354130Q125*COSMICMelanoma19422606
ENSP00000380093G413DCOSMICMelanoma19422606
ENSP00000354130G413DCOSMICMelanoma19422606
ENSP00000380093A361VCOSMICMelanoma19422606
ENSP00000354130R43QCOSMICMelanoma19422606
ENSP00000380093R43QCOSMICMelanoma19422606
ENSP00000354130A424VCOSMICMelanoma19422606
ENSP00000380093H414YCOSMICMelanoma19422606

Differential expressed protein
SOX10_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SOX10_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
FGFR4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
RAF1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
HIPK4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
MK01_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
SNRK_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
PXK_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
NRBP2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
DDR1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
AURKB_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
TGFR2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
NEK4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
CHK2_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
KC1E_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
KPCI_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
PIM1_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
CDK5_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
CDK7_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
CSK22_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
MK09_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
RAGE_HUMANSOX10_HUMANkinase -> substrateRobert H Newman (2013)
SOX10_HUMANMITF_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
SOX10_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005634nucleusIEAcellular_component
GO:0006357regulation of transcription from RNA polymerase IITASbiological_process
GO:0030154cell differentiationIEAbiological_process
GO:0090090negative regulation of canonical Wnt receptor signIEAbiological_process
GO:0048863stem cell differentiationIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0030318melanocyte differentiationIEAbiological_process
GO:0048484enteric nervous system developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0002052positive regulation of neuroblast proliferationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0048709oligodendrocyte differentiationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0048589developmental growthIEAbiological_process
GO:0014015positive regulation of gliogenesisIEAbiological_process
GO:0001755neural crest cell migrationIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0000980RNA polymerase II distal enhancer sequence-specifiIEAmolecular_function
GO:0031315extrinsic to mitochondrial outer membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0000981sequence-specific DNA binding RNA polymerase II trIEAmolecular_function
GO:0044212transcription regulatory region DNA bindingIEAmolecular_function
GO:0048546digestive tract morphogenesisIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0006366transcription from RNA polymerase II promoterIEAbiological_process
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0048469cell maturationIEAbiological_process
GO:0008134transcription factor bindingIEAmolecular_function
GO:0000978RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0007422peripheral nervous system developmentIEAbiological_process
GO:0003713transcription coactivator activityTASmolecular_function
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0009653anatomical structure morphogenesisTASbiological_process
GO:0042802identical protein bindingIPImolecular_function