Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SNAI1_HUMAN
Description:snail homolog 1 (Drosophila) [Source:HGNC Symbol;Acc:11128]
Location:chr20 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S96LSDEDsGKGSQCAP_NPhosphoSitePlus
S111PSPAPsSFSSTCAP_NPhosphoSitePlus
T201QGHVRtHTGEKzf-H2C2_2PhosphoSitePlus
S90VAELTsLSDEDCAP_NPhosphoSitePlus
S92ELTSLsDEDSGCAP_NPhosphoSitePlus
T203HVRTHtGEKPFzf-H2C2_2PhosphoSitePlus
S104GSQPPsPPSPAGSK-3_betaphosphoELM
S100DSGKGsQPPSPCAP_NPhosphoSitePlus
S82LRLQEsPRVAECAP_NPhosphoSitePlus
S115PSSFSsTSVSSCAP_NPhosphoSitePlus
S11LVRKPsDPNRKPhosphoSitePlus
S92ELTSLsDEDSGHPRD; phosphoELM
S246CARTFsRMSLLPAK1phosphoELM
S104GSQPPsPPSPACAP_NPhosphoSitePlus
S119SSTSVsSLEAECAP_NPhosphoSitePlus
S96LSDEDsGKGSQphosphoELM
S246CARTFsRMSLLzf-H2C2_2; CxxC_CxxC_SSSSPhosphoSitePlus
S107PPSPPsPAPSSGSK-3_betaphosphoELM
S107PPSPPsPAPSSCAP_NPhosphoSitePlus

Dephosphorylation site
SNAI1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000244050R215HTCGA, COSMICOvarian Cancer21720365, 18772890
ENSP00000244050E48DCOSMICOvarian Cancer21720365

Differential expressed protein
SNAI1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SNAI1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANSNAI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
ZAGL2_HUMANSNAI1_HUMANkinase -> substrateRegPhos
GSK3B_HUMANSNAI1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0001078RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0010718positive regulation of epithelial to mesenchymal tIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0019900kinase bindingIPImolecular_function
GO:2000810regulation of tight junction assemblyIMPbiological_process
GO:0001649osteoblast differentiationIEPbiological_process
GO:0043518negative regulation of DNA damage response, signalIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0060806negative regulation of cell differentiation involvIEAbiological_process
GO:0001837epithelial to mesenchymal transitionIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0001078RNA polymerase II core promoter proximal region seIEAmolecular_function
GO:0060021palate developmentIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIMPbiological_process
GO:0010718positive regulation of epithelial to mesenchymal tTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0060536cartilage morphogenesisIEAbiological_process
GO:0016477cell migrationIEAbiological_process
GO:0061314Notch signaling involved in heart developmentIEAbiological_process
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0060707trophoblast giant cell differentiationIEAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0043066negative regulation of apoptotic processIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0030335positive regulation of cell migrationIEAbiological_process
GO:0001707mesoderm formationIEAbiological_process
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0006357regulation of transcription from RNA polymerase IIIEAbiological_process
GO:0060972left/right pattern formationIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0000122negative regulation of transcription from RNA polyISSbiological_process
GO:0007498mesoderm developmentIEAbiological_process
GO:0010957negative regulation of vitamin D biosynthetic procIDAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0061314Notch signaling involved in heart developmentISSbiological_process
GO:0001707mesoderm formationISSbiological_process
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0001837epithelial to mesenchymal transitionISSbiological_process