Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:2A5D_HUMAN
Description:protein phosphatase 2, regulatory subunit B', delta [Source:HGNC Symbol;Acc:9312]
Location:chr6 p21.1
Node attribute:substrate; phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y488DCTQQyKAEKQB56; 7TM_GPCR_SrxPhosphoSitePlus
Y519RLNPQyPMFRAPhosphoSitePlus
S89ERRQSsSRFNLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y451MFPALyRNSKSB56; 7TM_GPCR_SrxPhosphoSitePlus
T538SMETEtPTAEDPhosphoSitePlus
S467LLRRKsELPQDHPRD
Y532PLPPVySMETEPhosphoSitePlus
S88KERRQsSSRFNPhosphoSitePlus; HPRD; phosphoELM
S62KRPSNsTPPPTPhosphoSitePlus
S60SNKRPsNSTPPPhosphoSitePlus
T429SHWNKtIHGLIHPRD
T581PQDVYtIKALEPhosphoSitePlus
T553KRTVEtEAVQMPhosphoSitePlus
S54QSQPPsSNKRPPhosphoSitePlus
S75SKIKYsGGPQIPhosphoSitePlus
S90RRQSSsRFNLSPhosphoSitePlus; HPRD
Y580LPQDVyTIKALPhosphoSitePlus
T63RPSNStPPPTQPhosphoSitePlus
S598EFLTAsQEAL_PhosphoSitePlus; SysPTM
S573LLRRKsELPQDPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T355SHWNKtIHGLIHPRD
S566EFLTAsQEHPRD
S533LPPVYsMETETPhosphoSitePlus
S598EFLTAsQEHPRD; phosphoELM; SysPTM
T536VYSMEtETPTAPhosphoSitePlus
S492EFLTAsQEHPRD
Y74LSKIKySGGPQPhosphoSitePlus
T461SHWNKtIHGLIHPRD
S95SRFNLsKNRELPhosphoSitePlus
S541LLRRKsELPQDHPRD

Dephosphorylation site
2A5D_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000417963G267STCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000417963E510DCOSMICOvarian Cancer21720365
ENSP00000420674P223SBIOMARTBreast Cancer21930507, 21930502
ENSP00000417963G267SCOSMICCentral Nervous System Neoplasms18772890
ENSP00000417963P329SBIOMARTBreast Cancer21930507, 21930502
ENSP00000377669P297SBIOMARTBreast Cancer21930507, 21930502
ENSP00000417963R123HCOSMICSkin Cancer21984974
ENSP00000417963L139FCOSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000377669Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4918646787

Hyperphosphorylation site
2A5D_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TGFR2_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
MARK3_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
KCC1B_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
CLK3_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
WNK1_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
BUB1_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
KCC4_HUMAN2A5D_HUMANkinase -> substrateRobert H Newman (2013)
2A5D_HUMANHAND1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04114Oocyte meiosis
hsa04728Dopaminergic synapse
hsa04310Wnt signaling pathway
hsa03015mRNA surveillance pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:0007165signal transductionIEAbiological_process
GO:0005488bindingIEAmolecular_function
GO:0000159protein phosphatase type 2A complexIEAcellular_component
GO:0005634nucleusIEAcellular_component
GO:0008601protein phosphatase type 2A regulator activityIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0007399nervous system developmentTASbiological_process


Fatal error: Uncaught Error: Call to undefined function mysql_close() in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php:23 Stack trace: #0 /usr/local/apache/htdocs/PhoSigNet/proteintable.php(435): db_disconnect(Object(mysqli)) #1 {main} thrown in /usr/local/apache/htdocs/PhoSigNet/include/locateconfig.inc.php on line 23