Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MERL_HUMAN
Description:neurofibromin 2 (merlin) [Source:HGNC Symbol;Acc:7773]
Location:chr22 q12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S435DMKRLsMEIEKHPRD
S587LQSAKsRVAFFERMPhosphoSitePlus
S518DMKRLsMEIEKPAK_groupphosphoELM; RegPhos; SysPTM
T581TIKKLtLQSAKERMPhosphoSitePlus
T435LLEIAtKPTYPHPRD
T477LLEIAtKPTYPHPRD
S435DMKRLsMEIEKPAK1HPRD
S518DMKRLsMEIEKPAK1HPRD; RegPhos; SysPTM
S518DMKRLsMEIEKPAK2phosphoELM; RegPhos; SysPTM
S10IASRMsFSSLKPhosphoSitePlus
T230RNKKGtELLLGFERM_CPhosphoSitePlus
T394LLEIAtKPTYPHPRD
S518DMKRLsMEIEKHPRD; phosphoELM; RegPhos; SysPTM
S315RRKADsLEVQQFERM_CPhosphoSitePlus
T477LLEIAtKPTYPERMPhosphoSitePlus
S477DMKRLsMEIEKHPRD
S476DMKRLsMEIEKHPRD
S13RMSFSsLKRKQPhosphoSitePlus
S518DMKRLsMEIEKPKA_groupphosphoELM; RegPhos; SysPTM
T436LLEIAtKPTYPHPRD
S518DMKRLsMEIEKERMPhosphoSitePlus; SysPTM
S477DMKRLsMEIEKPAK1HPRD
S476DMKRLsMEIEKPAK1HPRD

Dephosphorylation site
MERL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000344666H534fs*16COSMICNeoplasms by Histologic Type12011146
ENSP00000344666L458fs*27COSMICNeoplasms by Histologic Type8698340
ENSP00000344666M363fs*12COSMICBrain Cancer8162072
ENSP00000344666R198*COSMICNeoplasms by Histologic Type8698340
ENSP00000344666Y217fs*3COSMICBrain Cancer17222329
ENSP00000344666L117ICOSMICBrain Cancer8655144
ENSP00000344666E38*COSMICBrain Cancer16786152
ENSP00000344666D45fs*78COSMICNeoplasms by Histologic Type8012353
ENSP00000344666A448fs*7COSMICBrain Cancer16612978
ENSP00000344666P246fs*5COSMICNeoplasms by Histologic Type8698340
ENSP00000344666I273FHPIbreast ductal carcinoma8162073
ENSP00000344666A395VCOSMICIntestines Cancer8069299
ENSP00000344666V24fs*1COSMICBrain Cancer16786152
ENSP00000344666L141RCOSMICBrain Cancer20930055
ENSP00000344666Q538fs*12COSMICNeoplasms by Histologic Type8698340
ENSP00000344666Y221CTCGAOvarian Cancer21720365, 18772890
ENSP00000344666I546fs*4COSMICNeoplasms by Histologic Type8698340
ENSP00000344666T21fs*4COSMICBrain Cancer7669741
ENSP00000344666K471fs*14COSMICNeoplasms by Histologic Type7669741
ENSP00000344666K79ECOSMICNeoplasms by Histologic Type7951231
ENSP00000344666Q456*COSMICNeoplasms by Histologic Type12011146
ENSP00000344666Y101*COSMICBrain Cancer7911002
ENSP00000344666Q453fs*2COSMICNeoplasms by Histologic Type8889506
ENSP00000344666D70fs*53COSMICBrain Cancer7911002
ENSP00000344666Y481*COSMICNeoplasms by Histologic Type12011146
ENSP00000344666Y221CCOSMICOvarian Cancer21720365
ENSP00000344666Y192*COSMICBrain Cancer16612978
ENSP00000344666Y528fs*1COSMICNeoplasms by Histologic Type8698340
ENSP00000344666Y221fs*30COSMICBrain Cancer8655144
ENSP00000344666L127fs*1COSMICBrain Cancer17222329
ENSP00000344666V219MCOSMICBrain Cancer7669741
ENSP00000344666E247KTCGAOvarian Cancer21720365, 18772890
ENSP00000344666K332fs*14COSMICBrain Cancer17222329
ENSP00000344666T251fs*45COSMICBrain Cancer17222329
ENSP00000344666E524fs*26COSMICNeoplasms by Histologic Type8889506
ENSP00000344666E106*COSMICNeoplasms by Histologic Type8889506
ENSP00000344666E378fs*48COSMICBrain Cancer11668501
ENSP00000344666Q147*COSMICBrain Cancer7717450
ENSP00000344666A464fs*21COSMICBrain Cancer17222329
ENSP00000344666Y101fs*22COSMICNeoplasms by Histologic Type8698340
ENSP00000344666E206fs*3COSMICMelanoma8162073
ENSP00000344666A211DCOSMICBrain Cancer15609345
ENSP00000344666Y244fs*1COSMICNeoplasms by Histologic Type7529050
ENSP00000344666E204fs*5COSMICBrain Cancer7717450
ENSP00000344666D201fs*8COSMICCentral Nervous System Neoplasms8805149
ENSP00000344666T114fs*9COSMICNeoplasms by Histologic Type8889506
ENSP00000344666R462fs*23COSMICNeoplasms by Histologic Type10394935
ENSP00000344666W41CCOSMICNeoplasms by Histologic Type8698340
ENSP00000344666Q389*COSMICBrain Cancer16612978
ENSP00000344666R16fs*9COSMICNeoplasms by Histologic Type8889506
ENSP00000344666Q65*COSMICBrain Cancer16786152
ENSP00000344666E463KHPIBreast Cancer16959974
ENSP00000344666E350fs*14COSMICBrain Cancer8162072
ENSP00000344666S315fs*7COSMICNeoplasms by Histologic Type8889506
ENSP00000344666V282fs*14COSMICNeoplasms by Histologic Type8012353
ENSP00000344666Q400fs*26COSMICBrain Cancer8162072
ENSP00000344666E463KSjoblom2006Neoplasms by Histologic Type16959974, 18428421, 7669741
ENSP00000344666E247KCOSMICOvarian Cancer21720365
ENSP00000344666E89fs*34COSMICNeoplasms by Histologic Type8889506
ENSP00000344666A223fs*28COSMICBrain Cancer8162072
ENSP00000344666L46RCOSMICBrain Cancer7669741
ENSP00000344666P257fs*39COSMICNeoplasms by Histologic Type17222254
ENSP00000344666Q324LCOSMICBrain Cancer7717450
ENSP00000344666R172fs*2COSMICUterine Cancer
ENSP00000344666S87fs*36COSMICBrain Cancer10901233
ENSP00000344666Q147fs*27COSMICNeoplasms by Histologic Type8012353
ENSP00000344666I487VCOSMICIntestines Cancer7497438
ENSP00000344666K149NCOSMICBrain Cancer16612978
ENSP00000344666K289*COSMICBrain Cancer17222329
ENSP00000344666E231*COSMICBreast Cancer17088437
ENSP00000344666K149fs*25COSMICNeoplasms by Histologic Type8012353
ENSP00000344666I273FCOSMICBreast Cancer8162073
ENSP00000344666E422fs*4COSMICBrain Cancer16786152
ENSP00000344666Y177*COSMICNeoplasms by Histologic Type18285426
ENSP00000344666Q298*COSMICNeoplasms by Histologic Type18072270
ENSP00000344666P91fs*32COSMICBrain Cancer15609345
ENSP00000344666F35fs*5COSMICBrain Cancer11668501
ENSP00000344666E463KCOSMICNeoplasms by Histologic Type7669741
ENSP00000344666E347fs*17COSMICNeoplasms by Histologic Type8889506
ENSP00000344666W191RCOSMICNeoplasms by Histologic Type19691769
ENSP00000344666G235*COSMICBrain Cancer16612978
ENSP00000344666Y207*COSMICBrain Cancer8162072
ENSP00000344666K44fs*79COSMICBrain Cancer8655144
ENSP00000344666Q470*COSMICNeoplasms by Histologic Type7669741
ENSP00000344666Q410*COSMICNeoplasms by Histologic Type12011146
ENSP00000344666R346SCOSMICNeoplasms by Histologic Type18285426
ENSP00000344666P181fs*28COSMICBrain Cancer8559307
ENSP00000344666E270fs*26COSMICBrain Cancer16612978
ENSP00000344666G161*COSMICBrain Cancer9126902
ENSP00000344666S156RCOSMICBrain Cancer16786152
ENSP00000344666L214fs*6COSMICNeoplasms by Histologic Type12665675
ENSP00000344666E357*COSMICNeoplasms by Histologic Type7529050
ENSP00000344666P170fs*4COSMICNeoplasms by Histologic Type12821741
ENSP00000344666L163fs*11COSMICBrain Cancer16786152
ENSP00000344666E541fs*9COSMICNeoplasms by Histologic Type12011146
ENSP00000344666R351fs*13COSMICBrain Cancer8655144
ENSP00000344666I26fs*14COSMICBrain Cancer7911002
ENSP00000344666I487fs*28COSMICNeoplasms by Histologic Type18072270
ENSP00000344666L75fs*48COSMICNeoplasms by Histologic Type8698340
ENSP00000344666M375fs*51COSMICNeoplasms by Histologic Type8889506
ENSP00000344666T419fs*7COSMICBrain Cancer16786152
ENSP00000344666E32*COSMICBrain Cancer16786152
ENSP00000344666L208fs*1COSMICCentral Nervous System Neoplasms8261460
ENSP00000344666Q337*COSMICBrain Cancer8162072
ENSP00000344666A313fs*9COSMICNeoplasms by Histologic Type8012353
ENSP00000344666P490fs*25COSMICNeoplasms by Histologic Type8698340
ENSP00000344666R52fs*71COSMICBrain Cancer17222329
ENSP00000344666K413fs*13COSMICBrain Cancer7669741
ENSP00000344666Q324*COSMICNeoplasms by Histologic Type12011146
ENSP00000344666Q470fs*15COSMICNeoplasms by Histologic Type8889506
ENSP00000344666A395fs*31COSMICNeoplasms by Histologic Type7529050
ENSP00000344666F271fs*25COSMICBrain Cancer16612978
ENSP00000344666W258*COSMICBrain Cancer20930055
ENSP00000344666T480fs*5COSMICNeoplasms by Histologic Type8698340
ENSP00000344666K130fs*44COSMICBrain Cancer11668501
ENSP00000344666Q428*COSMICBrain Cancer8162072
ENSP00000344666P134fs*40COSMICNeoplasms by Histologic Type8889506
ENSP00000344666Q389fs*37COSMICNeoplasms by Histologic Type8889506
ENSP00000344666E465fs*20COSMICRenal Cancer20054297
ENSP00000344666Q319*COSMICBrain Cancer20682713
ENSP00000344666D354fs*10COSMICBrain Cancer12821741
ENSP00000344666P102fs*21COSMICNeoplasms by Histologic Type20831745
ENSP00000344666L361fs*3COSMICNeoplasms by Histologic Type12011146
ENSP00000344666E463KSjoblom2006Breast Cancer16959974, 18428421, 7669741
ENSP00000344666R249fs*2COSMICNeoplasms by Histologic Type8698340
ENSP00000344666Q319fs*3COSMICNeoplasms by Histologic Type8889506
ENSP00000344666E247fs*4COSMICNeoplasms by Histologic Type12821741
ENSP00000344666G218fs*2COSMICNeoplasms by Histologic Type12011146
ENSP00000344666K228fs*23COSMICGastric Cancer
ENSP00000344666Q111*COSMICNeoplasms by Histologic Type12975302
ENSP00000344666W74*COSMICSarcoma
ENSP00000344666K364ICOSMICMelanoma8162073
ENSP00000344666E108fs*15COSMICNeoplasms by Histologic Type7529050
ENSP00000344666F47fs*76COSMICBrain Cancer11668501
ENSP00000344666A451fs*4COSMICBrain Cancer17222329
ENSP00000344666K44*COSMICBrain Cancer8622160
ENSP00000344666G197CCOSMICNeoplasms by Histologic Type8698340
ENSP00000344666Q212*COSMICNeoplasms by Histologic Type9852312
ENSP00000344666A203fs*6COSMICNeoplasms by Histologic Type7951231
ENSP00000344666K387ECOSMICBrain Cancer10790227
ENSP00000344666L398fs*28COSMICBrain Cancer16786152
ENSP00000344666L97fs*26COSMICNeoplasms by Histologic Type7529050
ENSP00000344666W191*COSMICNeoplasms by Histologic Type8698340
ENSP00000344666E392*COSMICBrain Cancer17222329
ENSP00000344666D78fs*45COSMICBrain Cancer16786152
ENSP00000344666A370fs*5COSMICBrain Cancer7911002
ENSP00000344666Q459*COSMICBrain Cancer7669741
ENSP00000344666T71fs*52COSMICNeoplasms by Histologic Type7669741
ENSP00000344666V50fs*73COSMICNeoplasms by Histologic Type9852312
ENSP00000344666Y144*COSMICBrain Cancer17222329
ENSP00000344666L239fs*12COSMICNeoplasms by Histologic Type7529050
ENSP00000344666E215*COSMICThyroid Carcinoma
ENSP00000344666R466fs*19COSMICBrain Cancer7657387
ENSP00000344666E206KTCGAOvarian Cancer21720365, 18772890
ENSP00000344666K289fs*7COSMICBrain Cancer7669741
ENSP00000344666W184*COSMICBrain Cancer20682713
ENSP00000344666Q400*COSMICBrain Cancer17222329
ENSP00000344666H116fs*7COSMICBrain Cancer7717450
ENSP00000344666E129fs*45COSMICBrain Cancer8559307
ENSP00000344666G161fs*13COSMICNeoplasms by Histologic Type8698340
ENSP00000344666K396fs*30COSMICBrain Cancer17222329
ENSP00000344666L339FCOSMICBrain Cancer8655144
ENSP00000344666S87*COSMICSarcoma
ENSP00000344666E422*COSMICBrain Cancer20682713
ENSP00000344666R57*COSMICNeoplasms by Histologic Type7669741
ENSP00000344666K449*COSMICNeoplasms by Histologic Type8889506
ENSP00000344666H84fs*39COSMICBrain Cancer17222329
ENSP00000344666R262*COSMICNeoplasms by Histologic Type18072270
ENSP00000344666E129*COSMICThyroid Carcinoma
ENSP00000344666Q165fs*9COSMICBrain Cancer20682713
ENSP00000344666Q125*COSMICNeoplasms by Histologic Type12821741
ENSP00000344666E167DCOSMICBrain Cancer16786152
ENSP00000344666E365fs*10COSMICBrain Cancer9126902
ENSP00000344666P482fs*3COSMICBrain Cancer15609345
ENSP00000344666R196*COSMICNeoplasms by Histologic Type8698340
ENSP00000344666R466*COSMICNeoplasms by Histologic Type7669741
ENSP00000344666Q362*COSMICUterine Cancer
ENSP00000344666A148fs*26COSMICNeoplasms by Histologic Type17216226
ENSP00000344666Q470LDing2008, COSMICLung Cancer18948947
ENSP00000344666E270DCOSMICBrain Cancer17222329
ENSP00000344666V526fs*24COSMICNeoplasms by Histologic Type8012353
ENSP00000344666V146ICOSMICBrain Cancer17222329
ENSP00000344666Y153*COSMICNeoplasms by Histologic Type12011146
ENSP00000344666Y153fs*1COSMICNeoplasms by Histologic Type20831745
ENSP00000344666R341*COSMICNeoplasms by Histologic Type7669741
ENSP00000344666Q407*COSMICNeoplasms by Histologic Type7529050
ENSP00000344666K429fs*10COSMICNeoplasms by Histologic Type8698340
ENSP00000344666N303fs*6COSMICCentral Nervous System Neoplasms10433955
ENSP00000344666T59fs*64COSMICBrain Cancer8655144
ENSP00000344666L56fs*67COSMICBrain Cancer7717450
ENSP00000344666Q298fs*11COSMICBrain Cancer16786152
ENSP00000344666L539HCOSMICNeoplasms by Histologic Type8698340

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000344666Breast CancerNormal vs. Cancercell lineUp4.820052998
ENSP00000344666Breast CancerNormal vs. Cancercell lineUp1.520052998
ENSP00000344666Breast CancerMetastasiscell lineDown0.3320052998

Hyperphosphorylation site
MERL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANMERL_HUMANkinase -> substrateHPRD; RegPhos
PAK2_HUMANMERL_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANMERL_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
MERL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030175filopodiumIEAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0030027lamellipodiumIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0030036actin cytoskeleton organizationIMPbiological_process
GO:0035330regulation of hippo signaling cascadeIMPbiological_process
GO:0046426negative regulation of JAK-STAT cascadeIDAbiological_process
GO:0032587ruffle membraneIEAcellular_component
GO:0005730nucleolusIDAcellular_component
GO:0005912adherens junctionIEAcellular_component
GO:0042127regulation of cell proliferationIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0070306lens fiber cell differentiationIEAbiological_process
GO:0031527filopodium membraneIEAcellular_component
GO:0001726ruffleIEAcellular_component
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:0030336negative regulation of cell migrationTASbiological_process
GO:0045216cell-cell junction organizationIEAbiological_process
GO:0043409negative regulation of MAPK cascadeIEAbiological_process
GO:0005856cytoskeletonIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0030864cortical actin cytoskeletonIEAcellular_component
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0042524negative regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0001953negative regulation of cell-matrix adhesionTASbiological_process
GO:0007398ectoderm developmentIEAbiological_process
GO:0019898extrinsic to membraneIEAcellular_component
GO:0022408negative regulation of cell-cell adhesionIDAbiological_process
GO:0008092cytoskeletal protein bindingIEAmolecular_function
GO:0005856cytoskeletonTAScellular_component
GO:0051496positive regulation of stress fiber assemblyIMPbiological_process
GO:0042518negative regulation of tyrosine phosphorylation ofIDAbiological_process
GO:0006469negative regulation of protein kinase activityIEAbiological_process
GO:0014010Schwann cell proliferationIMPbiological_process
GO:0032154cleavage furrowIEAcellular_component
GO:0008156negative regulation of DNA replicationIMPbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0005769early endosomeIDAcellular_component
GO:0001707mesoderm formationIEAbiological_process