| UniProt/SwissProt ID: | LIMK1_HUMAN |
| Description: | LIM domain kinase 1 [Source:UniProtKB/Swiss-Prot;Acc:P53667] |
| Location: | chr7 q11.23 |
| Node attribute: | kinase; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T261 | HDPHDtLGHGL | HPRD | |
| S427 | RGIIKsMDSQY | HPRD | |
| S287 | GEAGSsARQKP | PhosphoSitePlus | |
| T253 | RLLQLtLEHDP | PDZ | PhosphoSitePlus |
| S534 | KVDVFsFGIVL | Pkinase_Tyr | PhosphoSitePlus |
| S210 | DPGCMsPDVKN | PDZ | PhosphoSitePlus |
| S337 | RIFRPsDLIHG | PhosphoSitePlus; HPRD; SysPTM | |
| S296 | KPVLRsCSIDR | PhosphoSitePlus | |
| T229 | LEINGtPIRNV | PDZ | PhosphoSitePlus |
| T229 | LEINGtPIRNV | HPRD | |
| Y415 | NFITEyIKGGT | Pkinase_Tyr | PhosphoSitePlus |
| T508 | RKKRYtVVGNP | Pkinase_Tyr | PhosphoSitePlus |
| S274 | ETSPLsSPAYT | PhosphoSitePlus; HPRD | |
| S286 | SGEAGsSARQK | PhosphoSitePlus | |
| S323 | LGRSEsLRVVC | PhosphoSitePlus | |
| S313 | LGSPAsQRKDL | PhosphoSitePlus; HPRD | |
| S210 | DPGCMsPDVKN | HPRD | |
| T508 | RKKRYtVVGNP | PAK1 | HPRD; phosphoELM; RegPhos |
| T508 | RKKRYtVVGNP | CDC42BPA | HPRD |
| T508 | RKKRYtVVGNP | ROCK_group | phosphoELM; RegPhos |
| S298 | VLRSCsIDRSP | PhosphoSitePlus; phosphoELM; RegPhos | |
| S307 | SPGAGsLGSPA | PhosphoSitePlus; HPRD; phosphoELM | |
| S310 | AGSLGsPASQR | LIMK1 | HPRD |
| S310 | AGSLGsPASQR | PhosphoSitePlus; phosphoELM; RegPhos | |
| T253 | RLLQLtLEHDP | HPRD | |
| T508 | RKKRYtVVGNP | ROCK1 | HPRD; RegPhos |
| T508 | RKKRYtVVGNP | MRCKa | phosphoELM; RegPhos |
| S298 | VLRSCsIDRSP | LIMK1 | HPRD |
| S439 | WSQRVsFAKDI | HPRD | |
| S302 | CSIDRsPGAGS | PhosphoSitePlus; HPRD; phosphoELM | |
| T270 | GLGPEtSPLSS | PhosphoSitePlus | |
| S637 | YRRGEsGLPAH | PhosphoSitePlus; SysPTM | |
| Dephosphorylation site |
| LIMK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000394098 | G342E | COSMIC | Skin Cancer | 21984974 | ENSP00000394098 | G207D | COSMIC | Gastric Cancer | 21097718 | ENSP00000336740 | P518L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000394098 | P276Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000336740 | P276Q | COSMIC | Ovarian Cancer | 21720365 | ENSP00000336740 | G207D | COSMIC | Gastric Cancer | 21097718 | ENSP00000394098 | P518L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000336740 | G342E | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| LIMK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| LIMK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | LIMK1_HUMAN | kinase -> substrate | HPRD; RegPhos; Robert H Newman (2013) |
| MRCKA_HUMAN | LIMK1_HUMAN | kinase -> substrate | HPRD |
| LIMK1_HUMAN | COF1_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos |
| ZAGL2_HUMAN | LIMK1_HUMAN | kinase -> substrate | RegPhos |
| LIMK1_HUMAN | COF2_HUMAN | kinase -> substrate | HPRD; RegPhos |
| LIMK1_HUMAN | LIMK1_HUMAN | kinase -> substrate | HPRD |
| SRC_HUMAN | LIMK1_HUMAN | kinase -> substrate | KEGG |
| ROCK1_HUMAN | LIMK1_HUMAN | kinase -> substrate | KEGG; HPRD; RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04360 | Axon guidance |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0009103 | lipopolysaccharide biosynthetic process | IEA | biological_process |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0032233 | positive regulation of actin filament bundle assem | IDA | biological_process |
| GO:0005925 | focal adhesion | IEA | cellular_component |
| GO:0045773 | positive regulation of axon extension | ISS | biological_process |
| GO:0004672 | protein kinase activity | NAS | molecular_function |
| GO:0043005 | neuron projection | ISS | cellular_component |
| GO:0030036 | actin cytoskeleton organization | TAS | biological_process |
| GO:0004674 | protein serine/threonine kinase activity | TAS | molecular_function |
| GO:0016773 | phosphotransferase activity, alcohol group as acce | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0007266 | Rho protein signal transduction | TAS | biological_process |
| GO:0031072 | heat shock protein binding | IDA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0051444 | negative regulation of ubiquitin-protein ligase ac | IDA | biological_process |
| GO:0046982 | protein heterodimerization activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |