Phosphorylation

Protein information

Protein summary

Phosphorylation site

Dephosphorylation site

Mutation site

Differential expressed protein

Hyperphosphorylation site

Direct interaction pair

Function Annotation

Protein Summary

UniProt/SwissProt ID:	CDK5_HUMAN
Description:	cyclin-dependent kinase 5 [Source:HGNC Symbol;Acc:1774]
Location:	chr7 q36.1
Node attribute:	kinase; substrate

Phosphorylation site

Position	PhosphoPeptide	Catalytic kinase	Source
S159	PVRCYsAEVVT	CK1d	RegPhos
S46	DEGVPsSALRE	Pkinase	PhosphoSitePlus
T14	KIGEGtYGTVF	Pkinase	PhosphoSitePlus
T14	KIGEGtYGTVF		RegPhos
Y15	IGEGTyGTVFK		phosphoELM; SysPTM
Y15	IGEGTyGTVFK	Abl	phosphoELM; SysPTM
Y167	VVTLWyRPPDV	Pkinase	PhosphoSitePlus
Y239	PDYKPyPMYPA	Pkinase	PhosphoSitePlus
Y15	IGEGTyGTVFK	ABL1	HPRD; RegPhos; SysPTM
Y158	IPVRCySAEVV	Pkinase	PhosphoSitePlus
S72	HDVLHsDKKLT		HPRD; SysPTM
Y4	KLEK		HPRD
T17	EGTYGtVFKAK		HPRD; SysPTM
S159	PVRCYsAEVVT		RegPhos
S159	PVRCYsAEVVT	Pkinase	PhosphoSitePlus
Y15	IGEGTyGTVFK	Pkinase	PhosphoSitePlus; SysPTM
S159	PVRCYsAEVVT	CK1_group	phosphoELM; RegPhos
Y15	IGEGTyGTVFK	ABL1	RegPhos; SysPTM
T17	EGTYGtVFKAK	Pkinase	PhosphoSitePlus; SysPTM
S159	PVRCYsAEVVT	CSNK1D	HPRD
S72	HDVLHsDKKLT	Pkinase	PhosphoSitePlus; SysPTM
Y15	IGEGTyGTVFK	FYN	HPRD; RegPhos; SysPTM

Dephosphorylation site

CDK5_HUMAN do not have dephosphorylation site.

Mutation site

CDK5_HUMAN do not have mutation site.

Differential expressed protein

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000297518	Colorectal Cancer	Treatment (none vs transfected with HPV-16 E6 gene)	cell line	Up		15684709

Hyperphosphorylation site

CDK5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair

Source	Target	Relationship	Resource
CDK5_HUMAN	AMPH_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	LRIG1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	PKN1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	MTA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	TIF1A_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	A4_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	NFAC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	KKCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	MK12_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	UBE2A_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	PSN1_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
CDK5_HUMAN	IPP2_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
CDK5_HUMAN	CBL_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	DYN1_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	PPR1B_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	ZHX1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	FGR_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	MEF2D_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	ERBB3_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	VHL_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	M4K5_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	CSRP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	RAN_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	EZRI_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	DCX_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	MEF2A_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
FYN_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	ENC2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	ABI2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	ASAP3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	XRCC1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	KS6A2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	NMDE1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	SRC8_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	RFA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	MK07_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	CIP4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	OTU7B_HUMAN	kinase -> substrate	Robert H Newman (2013)
ZAGL2_HUMAN	CDK5_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	MDFI_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SRC_HUMAN	kinase -> substrate	HPRD; RegPhos; Robert H Newman (2013)
CDK5_HUMAN	MLX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SPN1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	HES1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	NEST_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	MBNL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	PTN2_HUMAN	kinase -> substrate	HPRD
CDK5_HUMAN	ZN397_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	RFOX2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	TAU_HUMAN	kinase -> substrate	RegPhos; NetPath
CDK5_HUMAN	P53_HUMAN	kinase -> substrate	RegPhos
KC1D_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD
CDK5_HUMAN	BCL3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	CDKA1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	IASPP_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	ETS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	ANDR_HUMAN	kinase -> substrate	NetPath
CDK5_HUMAN	T22D4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	2AAB_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SYUA_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	CSRP1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	PHB2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	RAD51_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	HCLS1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	PRDM1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SMYD2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SYN1_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	PRS6A_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	IF4A3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SOX10_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SMAD3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	CRY1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	EXOS3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	MDM4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	RGRF2_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	CDK16_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	MK10_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	DAXX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	DAB1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	NDEL1_HUMAN	kinase -> substrate	RegPhos
CDK5_HUMAN	IRF3_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	MP2K1_HUMAN	kinase -> substrate	HPRD; RegPhos
CDK5_HUMAN	WASF1_HUMAN	kinase -> substrate	HPRD
CDK5_HUMAN	SRS10_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	XRCC4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	ZYX_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	APBB1_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	MDM2_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SRF_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	SMAD4_HUMAN	kinase -> substrate	Robert H Newman (2013)
CDK5_HUMAN	PI51C_HUMAN	kinase -> substrate	HPRD
ABL1_HUMAN	CDK5_HUMAN	kinase -> substrate	HPRD; RegPhos

Function Annotation

KEGG Pathway

KEGG ID	Pathway
hsa05030	Cocaine addiction
hsa04360	Axon guidance
hsa05010	Alzheimer's disease

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0018105	peptidyl-serine phosphorylation	IEA	biological_process
GO:0021695	cerebellar cortex development	IEA	biological_process
GO:0048709	oligodendrocyte differentiation	IDA	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0030549	acetylcholine receptor activator activity	ISS	molecular_function
GO:0048813	dendrite morphogenesis	IEA	biological_process
GO:0048675	axon extension	TAS	biological_process
GO:0051402	neuron apoptotic process	TAS	biological_process
GO:0043025	neuronal cell body	IEA	cellular_component
GO:0021537	telencephalon development	IEA	biological_process
GO:0030549	acetylcholine receptor activator activity	IEA	molecular_function
GO:0045055	regulated secretory pathway	IEA	biological_process
GO:0004713	protein tyrosine kinase activity	IEA	molecular_function
GO:0050321	tau-protein kinase activity	IEA	molecular_function
GO:0061001	regulation of dendritic spine morphogenesis	ISS	biological_process
GO:0030334	regulation of cell migration	IEA	biological_process
GO:0043125	ErbB-3 class receptor binding	ISS	molecular_function
GO:0060079	regulation of excitatory postsynaptic membrane pot	IEA	biological_process
GO:0004693	cyclin-dependent protein kinase activity	ISS	molecular_function
GO:0016310	phosphorylation	IDA	biological_process
GO:0014069	postsynaptic density	IEA	cellular_component
GO:0048167	regulation of synaptic plasticity	IEA	biological_process
GO:0009611	response to wounding	IEA	biological_process
GO:0030900	forebrain development	IEA	biological_process
GO:0005856	cytoskeleton	IEA	cellular_component
GO:0048488	synaptic vesicle endocytosis	IEA	biological_process
GO:0019233	sensory perception of pain	IEA	biological_process
GO:0018105	peptidyl-serine phosphorylation	IDA	biological_process
GO:0014044	Schwann cell development	IEA	biological_process
GO:0007411	axon guidance	TAS	biological_process
GO:0051301	cell division	IEA	biological_process
GO:0002039	p53 binding	IEA	molecular_function
GO:0007519	skeletal muscle tissue development	IEA	biological_process
GO:0048488	synaptic vesicle endocytosis	TAS	biological_process
GO:0001764	neuron migration	TAS	biological_process
GO:0008306	associative learning	IEA	biological_process
GO:0021819	layer formation in cerebral cortex	IEA	biological_process
GO:0009790	embryo development	IEA	biological_process
GO:0005829	cytosol	TAS	cellular_component
GO:0021549	cerebellum development	IEA	biological_process
GO:0021987	cerebral cortex development	IEA	biological_process
GO:0031397	negative regulation of protein ubiquitination	IEA	biological_process
GO:0014069	postsynaptic density	ISS	cellular_component
GO:0048812	neuron projection morphogenesis	IEA	biological_process
GO:0009790	embryo development	ISS	biological_process
GO:0042220	response to cocaine	IEA	biological_process
GO:0007416	synapse assembly	IEA	biological_process
GO:0048167	regulation of synaptic plasticity	ISS	biological_process
GO:0071156	regulation of cell cycle arrest	TAS	biological_process
GO:0030175	filopodium	IEA	cellular_component
GO:0060078	regulation of postsynaptic membrane potential	IEA	biological_process
GO:0030425	dendrite	ISS	cellular_component
GO:0016301	kinase activity	ISS	molecular_function
GO:0006915	apoptotic process	IEA	biological_process
GO:0035418	protein localization to synapse	IEA	biological_process
GO:0016477	cell migration	IEA	biological_process
GO:0018107	peptidyl-threonine phosphorylation	IEA	biological_process
GO:0005886	plasma membrane	IEA	cellular_component
GO:0031594	neuromuscular junction	ISS	cellular_component
GO:0050321	tau-protein kinase activity	ISS	molecular_function
GO:0007409	axonogenesis	IEA	biological_process
GO:0043525	positive regulation of neuron apoptotic process	IEA	biological_process
GO:0021697	cerebellar cortex formation	IEA	biological_process
GO:0004693	cyclin-dependent protein kinase activity	IEA	molecular_function
GO:0042981	regulation of apoptotic process	TAS	biological_process
GO:0022038	corpus callosum development	IEA	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0048148	behavioral response to cocaine	IEA	biological_process
GO:0005176	ErbB-2 class receptor binding	IEA	molecular_function
GO:0005634	nucleus	ISS	cellular_component
GO:0021766	hippocampus development	IEA	biological_process
GO:0005829	cytosol	IEA	cellular_component
GO:0016079	synaptic vesicle exocytosis	TAS	biological_process
GO:0032801	receptor catabolic process	IEA	biological_process
GO:0030424	axon	ISS	cellular_component
GO:0007160	cell-matrix adhesion	IEA	biological_process
GO:0030425	dendrite	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0045956	positive regulation of calcium ion-dependent exocy	IEA	biological_process
GO:0008045	motor neuron axon guidance	IEA	biological_process
GO:0030426	growth cone	IEA	cellular_component
GO:0001963	synaptic transmission, dopaminergic	IEA	biological_process
GO:0032092	positive regulation of protein binding	IEA	biological_process
GO:0033136	serine phosphorylation of STAT3 protein	IEA	biological_process
GO:0016301	kinase activity	IEA	molecular_function
GO:0031175	neuron projection development	ISS	biological_process
GO:0006886	intracellular protein transport	IEA	biological_process
GO:0030054	cell junction	IEA	cellular_component
GO:0046826	negative regulation of protein export from nucleus	IEA	biological_process
GO:0004674	protein serine/threonine kinase activity	IEA	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0021954	central nervous system neuron development	IEA	biological_process
GO:0044428	nuclear part	IEA	cellular_component
GO:0007416	synapse assembly	TAS	biological_process
GO:0031914	negative regulation of synaptic plasticity	IEA	biological_process
GO:0045860	positive regulation of protein kinase activity	IEA	biological_process
GO:0001764	neuron migration	IEA	biological_process
GO:0005515	protein binding	IEA	molecular_function
GO:0004674	protein serine/threonine kinase activity	ISS	molecular_function
GO:0016533	cyclin-dependent protein kinase 5 holoenzyme compl	IEA	cellular_component
GO:0045211	postsynaptic membrane	IEA	cellular_component
GO:0006887	exocytosis	IEA	biological_process
GO:0031175	neuron projection development	IEA	biological_process
GO:0006913	nucleocytoplasmic transport	IEA	biological_process
GO:0030426	growth cone	ISS	cellular_component
GO:0016772	transferase activity, transferring phosphorus-cont	IEA	molecular_function
GO:0031594	neuromuscular junction	IEA	cellular_component
GO:0030182	neuron differentiation	IEA	biological_process
GO:0035249	synaptic transmission, glutamatergic	IEA	biological_process
GO:0004672	protein kinase activity	TAS	molecular_function
GO:0008542	visual learning	IEA	biological_process
GO:0007596	blood coagulation	TAS	biological_process
GO:0030866	cortical actin cytoskeleton organization	IEA	biological_process
GO:0007268	synaptic transmission	TAS	biological_process
GO:0030424	axon	IEA	cellular_component
GO:0043025	neuronal cell body	ISS	cellular_component
GO:0043125	ErbB-3 class receptor binding	IEA	molecular_function
GO:0004672	protein kinase activity	IEA	molecular_function
GO:0046777	protein autophosphorylation	IEA	biological_process
GO:0005176	ErbB-2 class receptor binding	ISS	molecular_function
GO:0061001	regulation of dendritic spine morphogenesis	IEA	biological_process
GO:2000251	positive regulation of actin cytoskeleton reorgani	TAS	biological_process
GO:0043525	positive regulation of neuron apoptotic process	ISS	biological_process
GO:0046875	ephrin receptor binding	IEA	molecular_function
GO:0045892	negative regulation of transcription, DNA-dependen	IMP	biological_process
GO:0005737	cytoplasm	ISS	cellular_component
GO:0030182	neuron differentiation	ISS	biological_process
GO:0043113	receptor clustering	IEA	biological_process
GO:0045786	negative regulation of cell cycle	IEA	biological_process
GO:0005634	nucleus	IEA	cellular_component
GO:0006468	protein phosphorylation	IEA	biological_process
GO:0070509	calcium ion import	IEA	biological_process
GO:0043204	perikaryon	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0051402	neuron apoptotic process	IEA	biological_process
GO:0030027	lamellipodium	IEA	cellular_component
GO:0090314	positive regulation of protein targeting to membra	IEA	biological_process
GO:0016020	membrane	ISS	cellular_component

Human Phosphorylation Mediated
Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated Signaling Transduction Network

PhoSigNet

Human Phosphorylation Mediated
Signaling Transduction Network