Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:CASP1_HUMAN
Description:caspase 1, apoptosis-related cysteine peptidase [Source:HGNC Symbol;Acc:1499]
Location:chr11 q22.3
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S376RKVRFsFEQPDPeptidase_C14PhosphoSitePlus
S227PEHKTsDSTFLPeptidase_C14PhosphoSitePlus
S16KLFIRsMGEGTCARDPhosphoSitePlus
T226RPEHKtSDSTFPeptidase_C14PhosphoSitePlus
S376RKVRFsFEQPDPAK1HPRD
T32DELLQtRVLNKCARDPhosphoSitePlus
T21SMGEGtINGLLCARDPhosphoSitePlus

Dephosphorylation site
CASP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000410076A329TCOSMICOvarian Cancer21720365
ENSP00000433138N205ICOSMICOvarian Cancer21720365
ENSP00000433138A329TCOSMICOvarian Cancer21720365
ENSP00000410076N205ICOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000410076Thyroid CarcinomaNormal vs. CancertissueUp2.717194741

Hyperphosphorylation site
CASP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANCASP1_HUMANkinase -> substrateHPRD
CASP1_HUMANANDR_HUMANotherNetPath
P53_HUMANCASP1_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04621NOD-like receptor signaling pathway
hsa05134Legionellosis
hsa05164Influenza A
hsa04623Cytosolic DNA-sensing pathway
hsa05132Salmonella infection
hsa05133Pertussis

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionTASbiological_process
GO:0008233peptidase activityIEAmolecular_function
GO:0005576extracellular regionIEAcellular_component
GO:0004197cysteine-type endopeptidase activityTASmolecular_function
GO:0032611interleukin-1 beta productionIEAbiological_process
GO:0006508proteolysisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0004197cysteine-type endopeptidase activityIEAmolecular_function
GO:0072559NLRP3 inflammasome complexIDAcellular_component
GO:0072558NLRP1 inflammasome complexIDAcellular_component
GO:0050718positive regulation of interleukin-1 beta secretioIEAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0072557IPAF inflammasome complexISScellular_component
GO:0006508proteolysisIDAbiological_process
GO:0035872nucleotide-binding domain, leucine rich repeat conTASbiological_process
GO:0042221response to chemical stimulusIEAbiological_process
GO:0016485protein processingIEAbiological_process
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityTASbiological_process
GO:0008219cell deathIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0072557IPAF inflammasome complexIEAcellular_component
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0050717positive regulation of interleukin-1 alpha secretiIEAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEPbiological_process
GO:0001666response to hypoxiaIEAbiological_process
GO:0008234cysteine-type peptidase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0097169AIM2 inflammasome complexIDAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIEAbiological_process
GO:0008656cysteine-type endopeptidase activator activity invTASmolecular_function
GO:0006917induction of apoptosisIEAbiological_process
GO:0071310cellular response to organic substanceIDAbiological_process
GO:0045087innate immune responseTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0033198response to ATPIEAbiological_process


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