Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BAD_HUMAN
Description:BCL2-associated agonist of cell death [Source:HGNC Symbol;Acc:936]
Location:chr11 q13.1
Node attribute:substrate; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T80SYPAGtEDDEGBcl-2_BADPhosphoSitePlus
S153TRVFQsWWDRNHPRD
S97PFRGRsRSAPPBcl-2_BAD; Bclx_interactPhosphoSitePlus; SysPTM
S118ELRRMsDEFVDRSK3RegPhos; SysPTM
S74IRSRHsSYPAGHPRD
S99RGRSRsAPPNLPKB_groupphosphoELM; SysPTM
S75RSRHSsYPAGTRSK-1phosphoELM
S99RGRSRsAPPNLphosphoELM; SysPTM
S124DEFVDsFKKGLBcl-2_BAD; Bclx_interactPhosphoSitePlus
S153TRVFQsWWDRNPRKACAHPRD
Y76SRHSSyPAGTEHPRD; phosphoELM
S134LPRPKsAGTATPAK1HPRD
S25RGLGPsPAGDGHPRD
S118ELRRMsDEFVDAKT_groupRegPhos; SysPTM
S32AGDGPsGSGKHBcl-2_BADPhosphoSitePlus
S134LPRPKsAGTATBcl-2_BADPhosphoSitePlus
S118ELRRMsDEFVDRSK-1phosphoELM; SysPTM
S34DGPSGsGKHHRBcl-2_BADPhosphoSitePlus
S118ELRRMsDEFVDPRKACAHPRD; SysPTM
Y110WAAQRyGRELRBcl-2_BAD; Bclx_interactPhosphoSitePlus
S75RSRHSsYPAGTPIM1HPRD; RegPhos
S75RSRHSsYPAGTPIM3HPRD; RegPhos
S75RSRHSsYPAGTPIM2HPRD; RegPhos
S75RSRHSsYPAGTPAK7HPRD
S75RSRHSsYPAGTp38a(MAPK14RegPhos
S75RSRHSsYPAGTAKT1HPRD; RegPhos
S25RGLGPsPAGDGBcl-2_BADPhosphoSitePlus
S71AVEIRsRHSSYBcl-2_BADPhosphoSitePlus
S91MGEEPsPFRGRBcl-2_BADPhosphoSitePlus
S99RGRSRsAPPNLAKT1HPRD; RegPhos; SysPTM
Y76SRHSSyPAGTEBcl-2_BADPhosphoSitePlus
S118ELRRMsDEFVDPIM2HPRD; RegPhos; SysPTM
S118ELRRMsDEFVDPIM3HPRD; RegPhos; SysPTM
S118ELRRMsDEFVDPIM1HPRD; RegPhos; SysPTM
S118ELRRMsDEFVDRPS6KA2HPRD; SysPTM
S118ELRRMsDEFVDRPS6KA1HPRD; SysPTM
S118ELRRMsDEFVDBcl-2_BAD; Bclx_interactPhosphoSitePlus; SysPTM
S118ELRRMsDEFVDRSK1RegPhos; SysPTM
S99RGRSRsAPPNLPIM1HPRD; RegPhos; SysPTM
S99RGRSRsAPPNLPIM2HPRD; RegPhos; SysPTM
T137PKSAGtATQMRBcl-2_BADPhosphoSitePlus
S99RGRSRsAPPNLRSK_groupphosphoELM; SysPTM
S118ELRRMsDEFVDPKACaRegPhos; SysPTM
S75RSRHSsYPAGTAKT_groupRegPhos
S118ELRRMsDEFVDPKA_groupRegPhos; SysPTM
S75RSRHSsYPAGTBcl-2_BADPhosphoSitePlus
S153TRVFQsWWDRNRPS6KA5HPRD
S153TRVFQsWWDRNRPS6KA1HPRD
S153TRVFQsWWDRNRSK3RegPhos
S153TRVFQsWWDRNMSK1RegPhos
S118ELRRMsDEFVDphosphoELM; SysPTM
S99RGRSRsAPPNLPIM3HPRD; RegPhos; SysPTM
S75RSRHSsYPAGTPKA_groupphosphoELM; RegPhos
S75RSRHSsYPAGTphosphoELM
S75RSRHSsYPAGTRPS6KA1HPRD
S75RSRHSsYPAGTRPS6KA2HPRD
S99RGRSRsAPPNLBcl-2_BAD; Bclx_interactPhosphoSitePlus; SysPTM
S99RGRSRsAPPNLPAK1phosphoELM; SysPTM
S75RSRHSsYPAGTRSK3RegPhos
S75RSRHSsYPAGTRSK1RegPhos
S75RSRHSsYPAGTRSK-2phosphoELM
S99RGRSRsAPPNLAKT_groupRegPhos; SysPTM
S118ELRRMsDEFVDAKT1HPRD; RegPhos; SysPTM
S153TRVFQsWWDRNPKACaRegPhos
S99RGRSRsAPPNLPKA_groupRegPhos; SysPTM
S75RSRHSsYPAGTPAK5RegPhos
S74IRSRHsSYPAGBcl-2_BADPhosphoSitePlus
S146MRQSSsWTRVFBcl-2_BADPhosphoSitePlus
S75RSRHSsYPAGTRSK_groupphosphoELM
S118ELRRMsDEFVDPAK1HPRD; SysPTM
S134LPRPKsAGTATHPRD; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S99PFRGRSRsAPPNLWAPPP3CAHPRD
S75EIRSRHSsYPAGTEDPPP3CAHPRD

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000309103S124FCOSMICCentral Nervous System Neoplasms18772396
ENSP00000378040S124FCOSMICCentral Nervous System Neoplasms18772396

Differential expressed protein
BAD_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S75Bcl-2_BADEIRSRHSsYPAGTEDovarian cancer21849418PhosphoSitePlus
S99Bcl-2_BAD; Bclx_interactPFRGRSRsAPPNLWAovarian cancer21849418PhosphoSitePlus
S118Bcl-2_BAD; Bclx_interactGRELRRMsDEFVDSFovarian cancer21849418PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
RAF1_HUMANBAD_HUMANkinase -> substrateKEGG
AKT1_HUMANBAD_HUMANkinase -> substrateNetPath
PAK4_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
EF2K_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
MP2K1_HUMANBAD_HUMANkinase -> substrateKEGG
AKT3_HUMANBAD_HUMANkinase -> substrateKEGG
PIM2_HUMANBAD_HUMANkinase -> substrateRegPhos
CLK2_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
KS6A2_HUMANBAD_HUMANkinase -> substrateRegPhos
PIM1_HUMANBAD_HUMANkinase -> substrateRegPhos
STK11_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANBAD_HUMANkinase -> substrateHPRD
PAK7_HUMANBAD_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANBAD_HUMANkinase -> substrateRegPhos
TNI3K_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
RIPK3_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
MK14_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
PIM3_HUMANBAD_HUMANkinase -> substrateRegPhos
KPCA_HUMANBAD_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
MARK2_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
ARBK1_HUMANBAD_HUMANkinase -> substrateRobert H Newman (2013)
KS6A5_HUMANBAD_HUMANkinase -> substrateHPRD; RegPhos
KS6A1_HUMANBAD_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
PP2BA_HUMANBAD_HUMANphosphatase -> substrateHPRD
CHP1_HUMANBAD_HUMANphosphatase -> substrateKEGG
BAD_HUMANCYC_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04722Neurotrophin signaling pathway
hsa05212Pancreatic cancer
hsa05213Endometrial cancer
hsa04012ErbB signaling pathway
hsa05160Hepatitis C
hsa04210Apoptosis
hsa05145Toxoplasmosis
hsa05221Acute myeloid leukemia
hsa05218Melanoma
hsa04370VEGF signaling pathway
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05223Non-small cell lung cancer
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa04910Insulin signaling pathway
hsa05010Alzheimer's disease
hsa05152Tuberculosis
hsa05203Viral carcinogenesis
hsa04510Focal adhesion
hsa05215Prostate cancer
hsa05210Colorectal cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008289lipid bindingIDAmolecular_function
GO:0019221cytokine-mediated signaling pathwayIEAbiological_process
GO:0005543phospholipid bindingIMPmolecular_function
GO:0051592response to calcium ionIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingTASbiological_process
GO:0097191extrinsic apoptotic signaling pathwayIMPbiological_process
GO:0046902regulation of mitochondrial membrane permeabilityIMPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0032355response to estradiol stimulusIEAbiological_process
GO:0009725response to hormone stimulusIEAbiological_process
GO:0046034ATP metabolic processIEAbiological_process
GO:0097193intrinsic apoptotic signaling pathwayIMPbiological_process
GO:0042593glucose homeostasisIEAbiological_process
GO:0010508positive regulation of autophagyTASbiological_process
GO:0042542response to hydrogen peroxideIEAbiological_process
GO:0090200positive regulation of release of cytochrome c froIMPbiological_process
GO:0030346protein phosphatase 2B bindingIEAmolecular_function
GO:0060154cellular process regulating host cell cycle in resIEAbiological_process
GO:0071316cellular response to nicotineIDAbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0010918positive regulation of mitochondrial membrane poteIEAbiological_process
GO:0046931pore complex assemblyIDAbiological_process
GO:0005741mitochondrial outer membraneIDAcellular_component
GO:0071247cellular response to chromateIEAbiological_process
GO:0046031ADP metabolic processIEAbiological_process
GO:0005829cytosolIEAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0032024positive regulation of insulin secretionISSbiological_process
GO:0009749response to glucose stimulusIEAbiological_process
GO:0010033response to organic substanceIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityISSbiological_process
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0046982protein heterodimerization activityIEAmolecular_function
GO:0019903protein phosphatase bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIEAbiological_process
GO:0032570response to progesterone stimulusIEAbiological_process
GO:0043280positive regulation of cysteine-type endopeptidaseIDAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0006007glucose catabolic processIEAbiological_process
GO:0035774positive regulation of insulin secretion involved IEAbiological_process
GO:0008656cysteine-type endopeptidase activator activity invIEAmolecular_function
GO:0001666response to hypoxiaIEAbiological_process
GO:0044342type B pancreatic cell proliferationIEAbiological_process
GO:0043422protein kinase B bindingIEAmolecular_function
GO:2000078positive regulation of type B pancreatic cell deveIEAbiological_process
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0033133positive regulation of glucokinase activityIEAbiological_process
GO:0006917induction of apoptosisIEAbiological_process
GO:0045471response to ethanolIEAbiological_process
GO:0034201response to oleic acidIEAbiological_process
GO:0006915apoptotic processIEAbiological_process
GO:0071456cellular response to hypoxiaIEPbiological_process
GO:0045579positive regulation of B cell differentiationIEAbiological_process
GO:0007173epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0032024positive regulation of insulin secretionIEAbiological_process
GO:0043065positive regulation of apoptotic processIMPbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0042981regulation of apoptotic processIEAbiological_process
GO:0050679positive regulation of epithelial cell proliferatiIMPbiological_process
GO:0014070response to organic cyclic compoundIEAbiological_process
GO:0008283cell proliferationIEAbiological_process
GO:0043200response to amino acid stimulusIEAbiological_process
GO:0071396cellular response to lipidIEAbiological_process
GO:0008543fibroblast growth factor receptor signaling pathwaTASbiological_process
GO:0043281regulation of cysteine-type endopeptidase activityIEAbiological_process
GO:0045582positive regulation of T cell differentiationIEAbiological_process
GO:0033574response to testosterone stimulusIEAbiological_process
GO:0005515protein bindingIPImolecular_function