| UniProt/SwissProt ID: | PRDM1_HUMAN |
| Description: | PR domain containing 1, with ZNF domain [Source:HGNC Symbol;Acc:9346] |
| Location: | chr6 q21 |
| Node attribute: | substrate; TF |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S227 | TQTQSsLKQPS | PhosphoSitePlus | |
| S641 | CHKRFsSTSNL | zf-H2C2_2 | PhosphoSitePlus |
| Dephosphorylation site |
| PRDM1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358087 | E693Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358092 | E729Q | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358085 | D123Y | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 | ENSP00000358087 | E707K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358092 | E743K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000358092 | P362S | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| PRDM1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PRDM1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRPK1_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYR1B_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | PRDM1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PRDM1_HUMAN | IFNB_HUMAN | TF -> target gene | TRANSFAC |
| PRDM1_HUMAN | ID3_HUMAN | TF -> target gene | TRANSFAC |
| PRDM1_HUMAN | PAX5_HUMAN | TF -> target gene | TRANSFAC |
| PRDM1_HUMAN | C2TA_HUMAN | TF -> target gene | TRANSFAC |
| PRDM1_HUMAN | SPIB_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| PRDM1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0030889 | negative regulation of B cell proliferation | IEA | biological_process |
| GO:0045579 | positive regulation of B cell differentiation | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0001893 | maternal placenta development | IEA | biological_process |
| GO:0001892 | embryonic placenta development | IEA | biological_process |
| GO:0010628 | positive regulation of gene expression | IEA | biological_process |
| GO:0001701 | in utero embryonic development | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0045165 | cell fate commitment | IEA | biological_process |
| GO:0007281 | germ cell development | IEA | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0031665 | negative regulation of lipopolysaccharide-mediated | IEA | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | TAS | molecular_function |
| GO:0042826 | histone deacetylase binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0000122 | negative regulation of transcription from RNA poly | IEA | biological_process |