Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:SRSF1_HUMAN
Description:serine/arginine-rich splicing factor 1 [Source:HGNC Symbol;Acc:10780]
Location:chr17 q22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y112APRGRyGPPSRPhosphoSitePlus
S242YSPRHsRSRSHPRD; phosphoELM
T187SHEGEtAYIRVPhosphoSitePlus
S2____MsGGGVIPhosphoSitePlus
S119PPSRRsENRVVPhosphoSitePlus
Y72AEDAVyGRDGYRRM_1PhosphoSitePlus
S227RSRSYsPRRSRPhosphoSitePlus; HPRD
S201GPRSPsYGRSRPhosphoSitePlus; HPRD; phosphoELM
Y189EGETAyIRVKVPhosphoSitePlus; HPRD
Y19NDCRIyVGNLPRRM_1PhosphoSitePlus
S116RYGPPsRRSENPhosphoSitePlus
S215RSRSRsRSRSNPhosphoSitePlus
S238GSPRYsPRHSRPhosphoSitePlus; HPRD; phosphoELM
S209RSRSRsRSRSRPhosphoSitePlus
S244PRHSRsRSRT_PhosphoSitePlus
S242YSPRHsRSRSRPhosphoSitePlus
S221RSRSNsRSRSYPhosphoSitePlus
S231YSPRRsRGSPRPhosphoSitePlus; HPRD; phosphoELM
S217RSRSRsRSNSRPhosphoSitePlus
Y202PRSPSyGRSRSPhosphoSitePlus; HPRD
Y149AGDVCyADVYRRRM_1PhosphoSitePlus
Y226SRSRSySPRRSPhosphoSitePlus; HPRD
S2GGVIHPRD; phosphoELM
S199VDGPRsPSYGRPhosphoSitePlus; HPRD; phosphoELM
S223RSNSRsRSYSPPhosphoSitePlus
Y153CYADVyRDGTGRRM_1PhosphoSitePlus
S234RRSRGsPRYSPPhosphoSitePlus; HPRD; phosphoELM
S219RSRSRsNSRSRPhosphoSitePlus
S246HSRSRsRT___PhosphoSitePlus
Y77YGRDGyDYDGYRRM_1PhosphoSitePlus
S205PSYGRsRSRSRPhosphoSitePlus; HPRD; phosphoELM
S211RSRSRsRSRSRPhosphoSitePlus
T248RSRSRt_____PhosphoSitePlus
Y237RGSPRySPRHSPhosphoSitePlus; HPRD
S133LPPSGsWQDLKRRM_1PhosphoSitePlus
S244PRHSRsRSHPRD
Y170KEDMTyAVRKLRRM_1PhosphoSitePlus
Y39DVFYKyGAIRDRRM_1PhosphoSitePlus
Y37IEDVFyKYGAIRRM_1PhosphoSitePlus
S225NSRSRsYSPRRPhosphoSitePlus; HPRD
S207YGRSRsRSRSRPhosphoSitePlus
S213RSRSRsRSRSRPhosphoSitePlus
T169RKEDMtYAVRKRRM_1PhosphoSitePlus

Dephosphorylation site
SRSF1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000258962P89SSjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000258962H140QCOSMICOvarian Cancer21720365
ENSP00000258962R85QCOSMICHead and Neck Cancer21798893
ENSP00000258962R51CCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000258962Hepatocellular CarcinomaNormal vs. CancertissueUp3.415759316
ENSP00000258962Lung CancerTreatment(none vs betulin-treatment)cell lineUp319085751
ENSP00000258962Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineUp220804217

Hyperphosphorylation site
SRSF1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ARAF_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
KPCZ_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
FGR_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
AKT1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
CLK1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
EPHA3_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
WEE1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
DYRK4_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
SRPK2_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
NEK2_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
GSK3A_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
M4K2_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
CLK3_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)
FYN_HUMANSRSF1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
SRSF1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0060048cardiac muscle contractionIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0003723RNA bindingIDAmolecular_function
GO:0006376mRNA splice site selectionTASbiological_process
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0008380RNA splicingIEAbiological_process
GO:0050733RS domain bindingIEAmolecular_function
GO:0006406mRNA export from nucleusTASbiological_process
GO:0000395mRNA 5'-splice site recognitionIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0006366transcription from RNA polymerase II promoterTASbiological_process
GO:0006369termination of RNA polymerase II transcriptionTASbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:0031124mRNA 3'-end processingTASbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006397mRNA processingTASbiological_process


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