| UniProt/SwissProt ID: | TB22A_HUMAN |
| Description: | TBC1 domain family, member 22A [Source:HGNC Symbol;Acc:1309] |
| Location: | chr22 q13.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S171 | QSLPHsATVTL | PhosphoSitePlus | |
| S135 | PPSPPsGDLRL | HPRD | |
| S147 | KSVSEsHTSCP | PhosphoSitePlus | |
| T50 | TAKMPtTPVKA | PhosphoSitePlus; HPRD | |
| S188 | STLSSsALSER | PhosphoSitePlus; HPRD | |
| S221 | RRLSWsGIPKP | RabGAP-TBC | PhosphoSitePlus |
| T173 | LPHSAtVTLGG | PhosphoSitePlus | |
| S219 | ELRRLsWSGIP | RabGAP-TBC | PhosphoSitePlus |
| T175 | HSATVtLGGTS | HPRD; phosphoELM | |
| S143 | LRLVKsVSESH | PhosphoSitePlus | |
| S221 | RRLSWsGIPKP | HPRD | |
| S219 | ELRRLsWSGIP | HPRD | |
| S145 | LVKSVsESHTS | PhosphoSitePlus | |
| T51 | AKMPTtPVKAK | PhosphoSitePlus; HPRD | |
| S167 | LQRSQsLPHSA | PhosphoSitePlus; HPRD | |
| S288 | DIPRMsPEALI | RabGAP-TBC | PhosphoSitePlus |
| T179 | VTLGGtSDPST | PhosphoSitePlus | |
| S165 | APLQRsQSLPH | PhosphoSitePlus; HPRD; phosphoELM | |
| S132 | EAEPPsPPSGD | PhosphoSitePlus; HPRD | |
| Dephosphorylation site |
| TB22A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000336724 | N423T | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000336724 | N423T | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| TB22A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| TB22A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| TNI3K_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GRK5_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PDPK1_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MAPK5_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ST17A_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DYRK2_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ANPRB_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| YES_HUMAN | TB22A_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| TB22A_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0032313 | regulation of Rab GTPase activity | IEA | biological_process |
| GO:0005097 | Rab GTPase activator activity | IEA | molecular_function |
| GO:0042803 | protein homodimerization activity | IDA | molecular_function |