Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:TB22A_HUMAN
Description:TBC1 domain family, member 22A [Source:HGNC Symbol;Acc:1309]
Location:chr22 q13.31
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S171QSLPHsATVTLPhosphoSitePlus
S135PPSPPsGDLRLHPRD
S147KSVSEsHTSCPPhosphoSitePlus
T50TAKMPtTPVKAPhosphoSitePlus; HPRD
S188STLSSsALSERPhosphoSitePlus; HPRD
S221RRLSWsGIPKPRabGAP-TBCPhosphoSitePlus
T173LPHSAtVTLGGPhosphoSitePlus
S219ELRRLsWSGIPRabGAP-TBCPhosphoSitePlus
T175HSATVtLGGTSHPRD; phosphoELM
S143LRLVKsVSESHPhosphoSitePlus
S221RRLSWsGIPKPHPRD
S219ELRRLsWSGIPHPRD
S145LVKSVsESHTSPhosphoSitePlus
T51AKMPTtPVKAKPhosphoSitePlus; HPRD
S167LQRSQsLPHSAPhosphoSitePlus; HPRD
S288DIPRMsPEALIRabGAP-TBCPhosphoSitePlus
T179VTLGGtSDPSTPhosphoSitePlus
S165APLQRsQSLPHPhosphoSitePlus; HPRD; phosphoELM
S132EAEPPsPPSGDPhosphoSitePlus; HPRD

Dephosphorylation site
TB22A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000336724N423TTCGAOvarian Cancer21720365, 18772890
ENSP00000336724N423TCOSMICOvarian Cancer21720365

Differential expressed protein
TB22A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
TB22A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
TNI3K_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
PKN1_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
GRK5_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
PDPK1_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
MAPK5_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
DYRK2_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
ANPRB_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)
YES_HUMANTB22A_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
TB22A_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005622intracellularIEAcellular_component
GO:0032313regulation of Rab GTPase activityIEAbiological_process
GO:0005097Rab GTPase activator activityIEAmolecular_function
GO:0042803protein homodimerization activityIDAmolecular_function


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