Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ARHG2_HUMAN
Description:Rho/Rac guanine nucleotide exchange factor (GEF) 2 [Source:HGNC Symbol;Acc:682]
Location:chr1 q22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S122RERPSsAIYPSPhosphoSitePlus
T148ILSQStDSLNMHPRD
S519TLDKPsVVSLQPHPhosphoSitePlus
T830GEERAtEAGSLPhosphoSitePlus
S695SGGNTsPGVTAphosphoELM
S133DSFRQsLLGSRPhosphoSitePlus
S136HFNDEsPLGLRHPRD
T694DSGGNtSPGVTphosphoELM
S163HFNDEsPLGLRPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T695DSGGNtSPGVTPhosphoSitePlus; HPRD
S109ALQSVsLRSKTPhosphoSitePlus
S886DPRRRsLPAGDPAK1HPRD; SysPTM
S691PLEPDsGGNTSPhosphoSitePlus; HPRD; SysPTM
Y894AGDALyLSFNPPhosphoSitePlus; HPRD; SysPTM
S145LRRILsQSTDSHPRD
S647SESLEsPRGERphosphoELM
S151LAKSVsTTNIAPhosphoSitePlus; phosphoELM
S952SEEEGsSRLSPPhosphoSitePlus
S953EEEGSsRLSPPPhosphoSitePlus; HPRD
S885DPRRRsSPQAMPAK1phosphoELM
S295HTRFLsQLLERRhoGEFPhosphoSitePlus
S722ADSDSsQRDRNPhosphoSitePlus
T392VTQRItKYPLLRhoGEFPhosphoSitePlus
T115LRSKTtIRERPPhosphoSitePlus
T774PEKQAtELALLHPRD
S913RLQDSsDPDTGHPRD
S121IRERPsSAIYPPhosphoSitePlus
T667DSGGNtSPGVTHPRD
Y125PSSAIyPSDSFPhosphoSitePlus
S940ERLQDsSDPDTPhosphoSitePlus; HPRD
Y510EKDQKyIFPTLPHPhosphoSitePlus
S711RTFNGsIELCRPhosphoSitePlus
S896DALYLsFNPPQPhosphoSitePlus
T184NMRNRtLSVESPhosphoSitePlus
T152AKSVStTNIAGPhosphoSitePlus; phosphoELM
S127SAIYPsDSFRQPhosphoSitePlus
S522KPSVVsLQNLIPHPhosphoSitePlus
S904RQELGsPEERLHPRD
S142SRRGRsSLSLAPhosphoSitePlus
S177SQSTDsLNMRNPhosphoSitePlus; HPRD
S719LCRADsDSSQRPhosphoSitePlus
S116RRGRSsLSLAKHPRD
T679VELLLtPREPAPhosphoSitePlus; HPRD; SysPTM
T651VELLLtPREPAHPRD
S782LCRANsRDGEAPhosphoSitePlus; HPRD
T455DPRAQtPVPGKPhosphoSitePlus
T672TSPGVtANGEAHPRD
T802PEKQAtELALLPhosphoSitePlus; HPRD
T310LCPGStRNFVIRhoGEFPhosphoSitePlus
T700TSPGVtANGEAHPRD; SysPTM
S143RRGRSsLSLAKPhosphoSitePlus; HPRD
S886DPRRRsLPAGDPhosphoSitePlus; SysPTM
S947DPDTGsEEEGSPhosphoSitePlus
S903NPPQPsRGTDRPhosphoSitePlus
S172LRRILsQSTDSPhosphoSitePlus; HPRD
S617LFRSEsLESPRHPRD
S696SGGNTsPGVTAPhosphoSitePlus; HPRD; SysPTM
T945SSDPDtGSEEEPhosphoSitePlus
S663PLEPDsGGNTSHPRD
T153KSVSTtNIAGHPhosphoSitePlus; phosphoELM
S941RLQDSsDPDTGPhosphoSitePlus; HPRD
Y866AGDALyLSFNPHPRD
Y434VDEGIyQLEKGPhosphoSitePlus
S150SQSTDsLNMRNHPRD
S137QSLLGsRRGRSPhosphoSitePlus
S928GSSRLsPPHSPHPRD
S427VKELLsNVDEGRhoGEFPhosphoSitePlus
S948PEETEsRDGEAHPRD
S912ERLQDsSDPDTHPRD
S932LSPPHsPRDFTHPRD; SysPTM
S620SESLEsPRGERHPRD
Y356LYKELyARDKRRhoGEFPhosphoSitePlus
S149LSLAKsVSTTNPhosphoSitePlus; phosphoELM
S147RILSQsTDSLNHPRD
S644LFRSEsLESPRphosphoELM
S754LCRANsRDGEAHPRD
S858DPRRRsLPAGDPAK1HPRD
Y394QRITKyPLLISRhoGEFPhosphoSitePlus
S645LFRSEsLESPRPhosphoSitePlus; HPRD; SysPTM
S925EEEGSsRLSPPHPRD
S189TLSVEsLIDEAPhosphoSitePlus
S668SGGNTsPGVTAHPRD
S960LSPPHsPRDFTPhosphoSitePlus; HPRD
S129IYPSDsFRQSLPhosphoSitePlus
S648SESLEsPRGERPhosphoSitePlus; HPRD
S976PEETEsRDGEAPhosphoSitePlus; HPRD
S956GSSRLsPPHSPPhosphoSitePlus; HPRD
S643RGLFRsESLESPhosphoSitePlus
S309ALCPGsTRNFVRhoGEFPhosphoSitePlus
S174RILSQsTDSLNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S186RNRTLsVESLIPhosphoSitePlus
S932RQELGsPEERLPhosphoSitePlus; HPRD; SysPTM
S721RADSDsSQRDRPhosphoSitePlus
T175ILSQStDSLNMPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
ARHG2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000315325N681SCOSMICOvarian Cancer21720365
ENSP00000357299N681SCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000354837Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
ARHG2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANARHG2_HUMANkinase -> substrateHPRD; RegPhos; Robert H Newman (2013)
ZAGL2_HUMANARHG2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05130Pathogenic Escherichia coli infection

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043198dendritic shaftIEAcellular_component
GO:0007015actin filament organizationIMPbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0071474cellular hyperosmotic responseISSbiological_process
GO:0035023regulation of Rho protein signal transductionNASbiological_process
GO:0008017microtubule bindingIDAmolecular_function
GO:0007067mitosisIEAbiological_process
GO:0006886intracellular protein transportNASbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0000902cell morphogenesisIEAbiological_process
GO:0005923tight junctionIEAcellular_component
GO:0000132establishment of mitotic spindle orientationIEAbiological_process
GO:0005794Golgi apparatusIEAcellular_component
GO:0005819spindleIEAcellular_component
GO:0008270zinc ion bindingNASmolecular_function
GO:0048365Rac GTPase bindingIDAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0043066negative regulation of apoptotic processISSbiological_process
GO:0071356cellular response to tumor necrosis factorISSbiological_process
GO:0000902cell morphogenesisIMPbiological_process
GO:0008134transcription factor bindingISSmolecular_function
GO:0042127regulation of cell proliferationTASbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0050768negative regulation of neurogenesisIEAbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0017048Rho GTPase bindingIDAmolecular_function
GO:0007026negative regulation of microtubule depolymerizatioIMPbiological_process
GO:0005874microtubuleIDAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0007015actin filament organizationIEAbiological_process
GO:0005089Rho guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0030676Rac guanyl-nucleotide exchange factor activityIDAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0043025neuronal cell bodyIEAcellular_component
GO:0051092positive regulation of NF-kappaB transcription facIDAbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0032587ruffle membraneIDAcellular_component
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0008017microtubule bindingIEAmolecular_function
GO:0060547negative regulation of necrotic cell deathISSbiological_process
GO:0006915apoptotic processTASbiological_process
GO:0035556intracellular signal transductionIEAbiological_process