Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:M3K2_HUMAN
Description:mitogen-activated protein kinase kinase kinase 2 [Source:HGNC Symbol;Acc:6854]
Location:chr2 q14.3
Node attribute:substrate; kinase; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T524KSVTGtPYWMSPkinasePhosphoSitePlus
S311HSLSTsSGSSIHPRD
S493NILRDsTGNVKPkinasePhosphoSitePlus
S520GTGMKsVTGTPPkinasePhosphoSitePlus
T337DIDNPtLTVMDPhosphoSitePlus
S239MPRAQsYPDNHPhosphoSitePlus; HPRD; phosphoELM; SysPTM
T290PRARRtQGTSLPhosphoSitePlus
T432DPQEKtLSIFMPkinasePhosphoSitePlus
S297GTSLRsPVSFSPhosphoSitePlus; phosphoELM
S331IRRRGsDIDNPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S312SLSTSsGSSIFPhosphoSitePlus; HPRD
S514QTICLsGTGMKPkinasePhosphoSitePlus
S159IIGPTsRDRSSPhosphoSitePlus; HPRD; phosphoELM
S26SRPALsLQETRPhosphoSitePlus; phosphoELM
S153RKKRLsIIGPTPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S347DISPPsRSPRAHPRD; phosphoELM
T158SIIGPtSRDRSPhosphoSitePlus; HPRD
S315TSSGSsIFTPEPhosphoSitePlus; HPRD
T516ICLSGtGMKSVPkinasePhosphoSitePlus
S349SPPSRsPRAPTPhosphoSitePlus; HPRD
S300LRSPVsFSPTDPhosphoSitePlus; phosphoELM
T522GMKSVtGTPYWPkinasePhosphoSitePlus
S505GDFGAsKRLQTPkinasePhosphoSitePlus
S314STSSGsSIFTPHPRD
S163TSRDRsSPPPGPhosphoSitePlus; HPRD; phosphoELM
T310DHSLStSSGSSHPRD
S164SRDRSsPPPGYPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y240PRAQSyPDNHQPhosphoSitePlus
Y169SPPPGyIPDELPhosphoSitePlus
S248NHQEFsDYDNPPhosphoSitePlus
Y250QEFSDyDNPIFPhosphoSitePlus
S302SPVSFsPTDHSPhosphoSitePlus
S344TVMDIsPPSRSPhosphoSitePlus; HPRD; phosphoELM; SysPTM

Dephosphorylation site
M3K2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000387246*620YCOSMICIntestines Cancer16959974
ENSP00000343463M112IHPINon-small cell lung carcinoma17344846
ENSP00000387246P285SDing2008Lung Cancer18948947
ENSP00000343463*620YCOSMICIntestines Cancer16959974
ENSP00000387246M112IHPINon-small cell lung carcinoma17344846

Differential expressed protein
M3K2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
M3K2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
M3K2_HUMANIKBA_HUMANkinase -> substrateNetPath
M3K2_HUMANMP2K3_HUMANkinase -> substrateKEGG
PKN1_HUMANM3K2_HUMANkinase -> substrateKEGG
KPCA_HUMANM3K2_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04540Gap junction
hsa04010MAPK signaling pathway
hsa04912GnRH signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0007257activation of JUN kinase activityTASbiological_process
GO:0000187activation of MAPK activityTASbiological_process
GO:0006468protein phosphorylationTASbiological_process
GO:0046872metal ion bindingIEAmolecular_function
GO:0071260cellular response to mechanical stimulusIEPbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0004672protein kinase activityIDAmolecular_function
GO:0004674protein serine/threonine kinase activityTASmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004709MAP kinase kinase kinase activityIEAmolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0005515protein bindingIEAmolecular_function


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