| UniProt/SwissProt ID: | FOXN3_HUMAN |
| Description: | forkhead box N3 [Source:HGNC Symbol;Acc:1928] |
| Location: | chr14 q32.11 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T297 | RPLPItPIGVT | PhosphoSitePlus | |
| S8 | PVMPPsKKPES | PhosphoSitePlus | |
| T316 | SCRMRtESEPS | PhosphoSitePlus | |
| S97 | DDTPPsPAHSD | PhosphoSitePlus | |
| S432 | ARKVPsDTLPL | PhosphoSitePlus | |
| S318 | RMRTEsEPSCG | PhosphoSitePlus | |
| S83 | ESVLRsVSPVQ | PhosphoSitePlus | |
| S101 | PSPAHsDMPYD | PhosphoSitePlus | |
| S324 | EPSCGsPVVSG | PhosphoSitePlus | |
| S85 | VLRSVsPVQDL | PhosphoSitePlus | |
| Dephosphorylation site |
| FOXN3_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000452227 | T412I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000452227 | D42E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000452227 | S79L | COSMIC | Melanoma | 21499247 | ENSP00000452005 | S336F | COSMIC | Melanoma | ENSP00000452005 | D42E | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000452005 | T412I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000452227 | S336F | COSMIC | Melanoma | ENSP00000452005 | S79L | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| FOXN3_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| FOXN3_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | FOXN3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | FOXN3_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| FOXN3_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0008301 | DNA binding, bending | IBA | molecular_function |
| GO:0000077 | DNA damage checkpoint | TAS | biological_process |
| GO:0005667 | transcription factor complex | IBA | cellular_component |
| GO:0003705 | RNA polymerase II distal enhancer sequence-specifi | IBA | molecular_function |
| GO:0003690 | double-stranded DNA binding | IBA | molecular_function |
| GO:0008134 | transcription factor binding | IBA | molecular_function |
| GO:0009790 | embryo development | IBA | biological_process |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0007389 | pattern specification process | IBA | biological_process |
| GO:0009888 | tissue development | IBA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IEA | biological_process |
| GO:0043565 | sequence-specific DNA binding | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0000085 | G2 phase of mitotic cell cycle | TAS | biological_process |
| GO:0003700 | sequence-specific DNA binding transcription factor | IEA | molecular_function |
| GO:0051090 | regulation of sequence-specific DNA binding transc | IBA | biological_process |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |