| UniProt/SwissProt ID: | PHB2_HUMAN |
| Description: | prohibitin 2 [Source:HGNC Symbol;Acc:30306] |
| Location: | chr12 p13.31 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S119 | AQELPsMYQRL | Band_7 | PhosphoSitePlus |
| S151 | AKFNAsQLITQ | Band_7; Med2 | PhosphoSitePlus |
| S243 | LGEALsKNPGY | PhosphoSitePlus | |
| T263 | QNISKtIATSQ | PhosphoSitePlus | |
| S91 | RPRKIsSPTGS | Band_7 | PhosphoSitePlus |
| Y121 | ELPSMyQRLGL | Band_7 | PhosphoSitePlus |
| Y34 | AGAVAyGVRES | PhosphoSitePlus | |
| T21 | PRGMGtALKLL | PhosphoSitePlus | |
| Y77 | IPWFQyPIIYD | Band_7 | PhosphoSitePlus |
| Y128 | RLGLDyEERVL | Band_7 | PhosphoSitePlus |
| S293 | TRGSDsLIKGK | PhosphoSitePlus | |
| S135 | ERVLPsIVNEV | Band_7; Med2 | PhosphoSitePlus |
| Y81 | QYPIIyDIRAR | Band_7 | PhosphoSitePlus |
| Y248 | SKNPGyIKLRK | PhosphoSitePlus; phosphoELM | |
| Dephosphorylation site |
| PHB2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| PHB2_HUMAN do not have mutation site. |
| Differential expressed protein |
| PHB2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PHB2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| SRPK1_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DDR1_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KCC1D_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KS6B1_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PRKY_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | PHB2_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PHB2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0005743 | mitochondrial inner membrane | IEA | cellular_component |
| GO:0060762 | regulation of branching involved in mammary gland | IEA | biological_process |
| GO:0033147 | negative regulation of intracellular estrogen rece | IEA | biological_process |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0030331 | estrogen receptor binding | NAS | molecular_function |
| GO:0005743 | mitochondrial inner membrane | ISS | cellular_component |
| GO:0045892 | negative regulation of transcription, DNA-dependen | IEA | biological_process |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005634 | nucleus | ISS | cellular_component |
| GO:0033600 | negative regulation of mammary gland epithelial ce | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0060749 | mammary gland alveolus development | IEA | biological_process |
| GO:0060744 | mammary gland branching involved in thelarche | IEA | biological_process |