Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:MEN1_HUMAN
Description:multiple endocrine neoplasia I [Source:HGNC Symbol;Acc:7010]
Location:chr11 q13.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T402EQSQGtQSQGSMeninPhosphoSitePlus
S492GPRREsKPEEPMeninPhosphoSitePlus
T594KQKVStPSDYTHPRD
S394RPGEQsQGTQSHPRD
T557EGPVLtFQSEKMeninPhosphoSitePlus
T599KQKVStPSDYTHPRD; phosphoELM
S448TFLVQsLGRFEMeninPhosphoSitePlus
S487GPRREsKPEEPHPRD
S548PAPAAsPPPEGHPRD
S399RPGEQsQGTQSMeninPhosphoSitePlus
S598KKQKVsTPSDYHPRD
S399RPGEQsQGTQSHPRD; phosphoELM
T443HVGWAtFLVQSMeninPhosphoSitePlus
S492GPRREsKPEEPHPRD
S593KKQKVsTPSDYHPRD
S543PAPAAsPPPEGHPRD
S404SQGTQsQGSALMeninPhosphoSitePlus
T599KQKVStPSDYTMeninPhosphoSitePlus
S548PAPTAsPPPEGMeninPhosphoSitePlus

Dephosphorylation site
MEN1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000308975I86FCOSMICIntestines Cancer9354421
ENSP00000337088L157WHPIHead and Neck Cancer9709976
ENSP00000308975P291ACOSMICHead and Neck Cancer15754732
ENSP00000396940A289PHPIHead and Neck Cancer11034102
ENSP00000308975A345fs*23COSMICGastric Cancer15944766
ENSP00000308975Q450*COSMICPancreatic Cancer10027401
ENSP00000308975W126*COSMICHead and Neck Cancer10870030
ENSP00000308975E109*COSMICAdrenal Gland Neoplasms9935177
ENSP00000308975L22RCOSMICPancreatic Cancer21252315
ENSP00000308975Q166*COSMICGastric Cancer10634374
ENSP00000366530E279AHPIHead and Neck Cancer11034102 21819486
ENSP00000308975D17fs*102COSMICNeoplasms by Histologic Type11549677
ENSP00000308975E30*COSMICPancreatic Cancer21252315
ENSP00000308975I140fs*45COSMICGastric Cancer10634374
ENSP00000308975G42SCOSMICGastric Cancer9652567
ENSP00000308975A284PCOSMICHead and Neck Cancer10931084
ENSP00000308975G156DCOSMICHead and Neck Cancer11034102
ENSP00000308975F553fs*6COSMICHead and Neck Cancer11034102
ENSP00000377901S258WHPIHead and Neck Cancer11034102
ENSP00000377899S258WHPIHead and Neck Cancer11034102
ENSP00000308975E358GCOSMICOvarian Cancer21720365
ENSP00000308975E387fs*58COSMICPancreatic Cancer9766672
ENSP00000308975Q209*COSMICIntestines Cancer10027401
ENSP00000308975H433PCOSMICIntestines Cancer15944766
ENSP00000308975E378VCOSMICHead and Neck Cancer10856877
ENSP00000308975A164VCOSMICPancreatic Cancer21252315
ENSP00000308975P320RCOSMICPancreatic Cancer21252315
ENSP00000308975W126GCOSMICPancreatic Cancer9354421
ENSP00000308975S145RCOSMICPancreatic Cancer9766672
ENSP00000308975V451fs*7COSMICLung Cancer9361035
ENSP00000308975D136fs*49COSMICHead and Neck Cancer9709976
ENSP00000308975G225fs*56COSMICGastric Cancer10634374
ENSP00000308975W341*COSMICHead and Neck Cancer11034102
ENSP00000308975F159CCOSMICNeoplasms by Histologic Type9354421
ENSP00000396940S258WHPIHead and Neck Cancer11034102
ENSP00000308975A535VCOSMICPancreatic Cancer9354421
ENSP00000337088S258WHPIHead and Neck Cancer11034102
ENSP00000337088E279AHPIHead and Neck Cancer11034102 21819486
ENSP00000308975Y90fs*29COSMICPituitary Carcinoma10424779
ENSP00000308975K310*COSMICHead and Neck Cancer11034102
ENSP00000366530S258WHPIHead and Neck Cancer11034102
ENSP00000396940L157WHPIHead and Neck Cancer9709976
ENSP00000377901A289PHPIHead and Neck Cancer11034102
ENSP00000308975G419fs*26COSMICHead and Neck Cancer17555500
ENSP00000308975K454fs*4COSMICHead and Neck Cancer11034102
ENSP00000308975E179VCOSMICPancreatic Cancer10993646
ENSP00000308975R460*COSMICHead and Neck Cancer10715991
ENSP00000308975E473*COSMICGastric Cancer15944766
ENSP00000377899R300LDing2008Lung Cancer18948947
ENSP00000308975R98fs*21COSMICHead and Neck Cancer10870030
ENSP00000308975W471*COSMICCentral Nervous System Neoplasms11275983
ENSP00000308975S443PCOSMICHead and Neck Cancer11058905
ENSP00000308975R330PCOSMICPancreatic Cancer9766672
ENSP00000308975S253LCOSMICHead and Neck Cancer10931084
ENSP00000308975L175RCOSMICHead and Neck Cancer9709922
ENSP00000308975G208fs*16COSMICGastric Cancer10634374
ENSP00000308975L37PCOSMICPancreatic Cancer10027401
ENSP00000308975R115fs*4COSMICHead and Neck Cancer10931084
ENSP00000308975F410LCOSMICPituitary Carcinoma9407947
ENSP00000308975N51fs*68COSMICHead and Neck Cancer11058905
ENSP00000308975R98*COSMICGastric Cancer10634374
ENSP00000308975K135*COSMICNeoplasms by Histologic Type9740255
ENSP00000308975A49DCOSMICHead and Neck Cancer10870030
ENSP00000308975H139DCOSMICHead and Neck Cancer9709976
ENSP00000308975Y327*COSMICHead and Neck Cancer10870030
ENSP00000366530L157WHPIHead and Neck Cancer9709976
ENSP00000308975A138fs*47COSMICPancreatic Cancer9766672
ENSP00000308975P245fs*36COSMICPancreatic Cancer19525592
ENSP00000308975K569fs*19COSMICHead and Neck Cancer10931084
ENSP00000377899L157WHPIHead and Neck Cancer9709976
ENSP00000308975W183*COSMICPancreatic Cancer21252315
ENSP00000308975S543*COSMICPancreatic Cancer21252315
ENSP00000308975D406fs*39COSMICOther Cancer19564705
ENSP00000308975N374fs*3COSMICLung Cancer10738303
ENSP00000308975E388*COSMICHead and Neck Cancer10715991
ENSP00000308975Q349*COSMICMelanoma10918183
ENSP00000377901R300LDing2008Lung Cancer18948947
ENSP00000308975W183RCOSMICPancreatic Cancer21252315
ENSP00000308975E392*COSMICPancreatic Cancer9458074
ENSP00000308975D172VCOSMICLung Cancer10027401
ENSP00000337088A289PHPIHead and Neck Cancer11034102
ENSP00000308975L152WCOSMICHead and Neck Cancer9709976
ENSP00000308975W265fs*16COSMICGastric Cancer9652567
ENSP00000308975V53ICOSMICIntestines Cancer10027401
ENSP00000308975T552SCOSMICAdrenal Gland Neoplasms10647896
ENSP00000308975E60*COSMICHead and Neck Cancer11058905
ENSP00000308975Q393*COSMICOther Cancer10594843
ENSP00000308975P32RCOSMICPancreatic Cancer20403035
ENSP00000308975S543LCOSMICNeoplasms by Histologic Type9354421
ENSP00000308975K502MCOSMICPituitary Carcinoma9407947
ENSP00000337088R300LDing2008Lung Cancer18948947
ENSP00000366530A289PHPIHead and Neck Cancer11034102
ENSP00000308975F146fs*39COSMICHead and Neck Cancer10870030
ENSP00000308975D418NCOSMICHead and Neck Cancer9241276
ENSP00000308975E358*COSMICHead and Neck Cancer11034102
ENSP00000308975R14fs*105COSMICHead and Neck Cancer11549677
ENSP00000308975E26KCOSMICHead and Neck Cancer9241276
ENSP00000308975E45DCOSMICHead and Neck Cancer9709922
ENSP00000308975R415*COSMICPancreatic Cancer9458074
ENSP00000308975Q584*COSMICHead and Neck Cancer10856877
ENSP00000308975K119delCOSMICHead and Neck Cancer9709922
ENSP00000308975V121DCOSMICHead and Neck Cancer20480190
ENSP00000308975G225VCOSMICPancreatic Cancer21252315
ENSP00000308975R171QCOSMICAdrenal Gland Neoplasms10634422
ENSP00000308975S178YCOSMICPancreatic Cancer10594843
ENSP00000308975Q442*COSMICHead and Neck Cancer11058905
ENSP00000308975T346fs*22COSMICHead and Neck Cancer9709922
ENSP00000308975T580RCOSMICHead and Neck Cancer10931084
ENSP00000308975Q536*COSMICHead and Neck Cancer15754732
ENSP00000308975Q400*COSMICPancreatic Cancer21252315
ENSP00000308975L89RCOSMICPancreatic Cancer9458074
ENSP00000308975D82fs*37COSMICHead and Neck Cancer10931084
ENSP00000377899E279AHPIHead and Neck Cancer11034102 21819486
ENSP00000308975R108*COSMICHead and Neck Cancer9241276
ENSP00000308975I85VCOSMICLung Cancer20668451
ENSP00000308975F134fs*51COSMICGastric Cancer10634374
ENSP00000308975R295LCOSMICLung Cancer18948947
ENSP00000308975E469*COSMICHead and Neck Cancer11580998
ENSP00000308975Q141RCOSMICPancreatic Cancer9766672
ENSP00000308975M561TCOSMICHead and Neck Cancer9241276
ENSP00000377899A289PHPIHead and Neck Cancer11034102
ENSP00000377901L157WHPIHead and Neck Cancer9709976
ENSP00000366530R300LDing2008Lung Cancer18948947
ENSP00000396940E279AHPIHead and Neck Cancer11034102 21819486
ENSP00000308975V211FCOSMICHead and Neck Cancer17555500
ENSP00000377901E279AHPIHead and Neck Cancer11034102 21819486
ENSP00000308975G74fs*45COSMICHead and Neck Cancer11095441

Differential expressed protein
MEN1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
MEN1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANMEN1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
MEN1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030097hemopoiesisIEAbiological_process
GO:0043065positive regulation of apoptotic processIEAbiological_process
GO:0032092positive regulation of protein bindingIDAbiological_process
GO:0031062positive regulation of histone methylationIEAbiological_process
GO:0009790embryo developmentIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003682chromatin bindingIEAmolecular_function
GO:0032154cleavage furrowIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0006974response to DNA damage stimulusIDAbiological_process
GO:0000403Y-form DNA bindingIDAmolecular_function
GO:0046621negative regulation of organ growthIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0030674protein binding, bridgingIDAmolecular_function
GO:0045736negative regulation of cyclin-dependent protein kiIMPbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0002076osteoblast developmentIEAbiological_process
GO:0043433negative regulation of sequence-specific DNA bindiIDAbiological_process
GO:0045786negative regulation of cell cycleIDAbiological_process
GO:0047485protein N-terminus bindingIPImolecular_function
GO:0000785chromatinIDAcellular_component
GO:0005829cytosolIDAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0007179transforming growth factor beta receptor signalingTASbiological_process
GO:0009411response to UVIDAbiological_process
GO:0070412R-SMAD bindingIPImolecular_function
GO:0043234protein complexIDAcellular_component
GO:0000122negative regulation of transcription from RNA polyIEAbiological_process
GO:0001776leukocyte homeostasisIEAbiological_process
GO:0048704embryonic skeletal system morphogenesisIEAbiological_process
GO:0000400four-way junction DNA bindingIDAmolecular_function
GO:0007420brain developmentIEAbiological_process
GO:0060021palate developmentIEAbiological_process
GO:0030511positive regulation of transforming growth factor IMPbiological_process
GO:0051781positive regulation of cell divisionIEAbiological_process
GO:0006367transcription initiation from RNA polymerase II prTASbiological_process
GO:0035097histone methyltransferase complexIPIcellular_component
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0044212transcription regulatory region DNA bindingIDAmolecular_function
GO:0045669positive regulation of osteoblast differentiationIEAbiological_process
GO:0005737cytoplasmIEAcellular_component
GO:0043280positive regulation of cysteine-type endopeptidaseIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0010332response to gamma radiationIDAbiological_process
GO:0046329negative regulation of JNK cascadeIDAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIDAbiological_process
GO:0006351transcription, DNA-dependentTASbiological_process
GO:0002051osteoblast fate commitmentIEAbiological_process
GO:0000165MAPK cascadeIDAbiological_process
GO:0006281DNA repairNASbiological_process
GO:0045597positive regulation of cell differentiationIEAbiological_process
GO:0060135maternal process involved in female pregnancyIEAbiological_process
GO:0010467gene expressionTASbiological_process
GO:0003690double-stranded DNA bindingIDAmolecular_function
GO:0034968histone lysine methylationIDAbiological_process
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0051974negative regulation of telomerase activityIMPbiological_process
GO:0018024histone-lysine N-methyltransferase activityIDAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0006338chromatin remodelingIEAbiological_process
GO:0016363nuclear matrixIDAcellular_component
GO:0045668negative regulation of osteoblast differentiationIEAbiological_process
GO:0016571histone methylationIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0007050cell cycle arrestIEAbiological_process
GO:0032925regulation of activin receptor signaling pathwayIEAbiological_process
GO:0005654nucleoplasmTAScellular_component