| UniProt/SwissProt ID: | CXXC1_HUMAN |
| Description: | CXXC finger protein 1 [Source:HGNC Symbol;Acc:24343] |
| Location: | chr18 q21.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T521 | GSMYPtRIEGA | zf-CpG_bind_C | PhosphoSitePlus |
| Y405 | AANRIyEILPQ | zf-CpG_bind_C | PhosphoSitePlus |
| S224 | FPSSLsPVTPS | PhosphoSitePlus; HPRD; phosphoELM | |
| T227 | SLSPVtPSESL | PhosphoSitePlus; HPRD; phosphoELM | |
| S19 | GEDSKsENGEN | PhosphoSitePlus; HPRD | |
| S6 | MEGDGsDPEPP | PhosphoSitePlus | |
| S511 | YAKYEsQTSFG | zf-CpG_bind_C | PhosphoSitePlus |
| T126 | RAGSGtGVGAM | PhosphoSitePlus | |
| S124 | QRRAGsGTGVG | PhosphoSitePlus | |
| T513 | KYESQtSFGSM | HPRD | |
| S308 | GLPWMsDTEES | PhosphoSitePlus | |
| S6 | PEPP | HPRD | |
| S221 | YKYFPsSLSPV | PhosphoSitePlus | |
| Dephosphorylation site |
| CXXC1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000285106 | E474K | COSMIC | Head and Neck Cancer | ENSP00000285106 | F219L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000285106 | M190I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000285106 | L646F | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| CXXC1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| CXXC1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | CXXC1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| CXXC1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0006351 | transcription, DNA-dependent | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0048188 | Set1C/COMPASS complex | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0045322 | unmethylated CpG binding | IDA | molecular_function |
| GO:0006987 | activation of signaling protein activity involved | TAS | biological_process |
| GO:0042800 | histone methyltransferase activity (H3-K4 specific | IDA | molecular_function |
| GO:0016607 | nuclear speck | IDA | cellular_component |
| GO:0030968 | endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0016363 | nuclear matrix | IEA | cellular_component |
| GO:0045893 | positive regulation of transcription, DNA-dependen | IDA | biological_process |
| GO:0006355 | regulation of transcription, DNA-dependent | IDA | biological_process |
| GO:0035097 | histone methyltransferase complex | IDA | cellular_component |
| GO:0051568 | histone H3-K4 methylation | IDA | biological_process |