| UniProt/SwissProt ID: | RHG20_HUMAN |
| Description: | Rho GTPase activating protein 20 [Source:HGNC Symbol;Acc:18357] |
| Location: | chr11 q23.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S20 | PGRSSsLTGVS | PhosphoSitePlus | |
| S657 | KRPLEsKPVNI | PhosphoSitePlus | |
| T22 | RSSSLtGVSRL | PhosphoSitePlus | |
| Y242 | GSERDyQLWVN | RA | PhosphoSitePlus |
| S248 | QLWVNsGKEEA | RA | PhosphoSitePlus |
| S18 | GQPGRsSSLTG | PhosphoSitePlus | |
| Dephosphorylation site |
| RHG20_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000260283 | Q627E | COSMIC | Renal Cancer | 20054297 | ENSP00000260283 | F551L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260283 | T858S | COSMIC | Skin Cancer | 21984974 | ENSP00000260283 | D452G | COSMIC | Renal Cancer | 20054297 | ENSP00000260283 | D987E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000260283 | H643N | COSMIC | Skin Cancer | 21984974 | ENSP00000260283 | S516R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RHG20_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RHG20_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | RHG20_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RHG20_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |