| UniProt/SwissProt ID: | ARC1B_HUMAN |
| Description: | actin related protein 2/3 complex, subunit 1B, 41kDa [Source:HGNC Symbol;Acc:704] |
| Location: | chr7 q22.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S330 | HKNSVsQISVL | HPRD | |
| T21 | WNKDRtQIAIC | TFIIIC_delta | PhosphoSitePlus |
| T21 | WNKDRtQIAIC | PAK1 | HPRD; RegPhos |
| S336 | QISVLsGGKAK | HPRD | |
| S310 | LDKKAsSEGGT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S311 | DKKASsEGGTA | PhosphoSitePlus; HPRD; SysPTM | |
| T297 | SQRGLtARERF | PhosphoSitePlus | |
| T89 | RTWKPtLVILR | HPRD | |
| S355 | MDGGMsIWDVK | PhosphoSitePlus | |
| S170 | KCRIFsAYIKE | Rax2; WD40 | PhosphoSitePlus |
| S170 | KCRIFsAYIKE | HPRD | |
| T315 | SSEGGtAAGAG | HPRD; phosphoELM; RegPhos; SysPTM | |
| Y172 | RIFSAyIKEVE | HPRD | |
| Y172 | RIFSAyIKEVE | Rax2 | PhosphoSitePlus |
| Y35 | HEVHIyEKSGA | TFIIIC_delta | PhosphoSitePlus |
| S328 | SLHKNsVSQIS | HPRD | |
| Dephosphorylation site |
| ARC1B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| ARC1B_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000389631 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| ARC1B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | ARC1B_HUMAN | kinase -> substrate | HPRD; RegPhos |
| ZAGL2_HUMAN | ARC1B_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05132 | Salmonella infection |
| hsa05130 | Pathogenic Escherichia coli infection |
| hsa05131 | Shigellosis |
| hsa05100 | Bacterial invasion of epithelial cells |
| hsa04666 | Fc gamma R-mediated phagocytosis |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005856 | cytoskeleton | IEA | cellular_component |
| GO:0005200 | structural constituent of cytoskeleton | TAS | molecular_function |
| GO:0030833 | regulation of actin filament polymerization | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0015629 | actin cytoskeleton | TAS | cellular_component |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0006928 | cellular component movement | TAS | biological_process |
| GO:0003779 | actin binding | IEA | molecular_function |
| GO:0005885 | Arp2/3 protein complex | TAS | cellular_component |