Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:BPNT1_HUMAN
Description:3'(2'), 5'-bisphosphate nucleotidase 1 [Source:HGNC Symbol;Acc:1096]
Location:chr1 q41
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T248CKKWDtCAPEVInositol_PPhosphoSitePlus
S3NTVLHPRD
S61MSICSsLARKFInositol_PPhosphoSitePlus
S57RLAQMsICSSLInositol_PPhosphoSitePlus
Y16LVASAySIAQKInositol_PPhosphoSitePlus
S240AYVFAsPGCKKInositol_PPhosphoSitePlus
T6MASSNtVLMRLPhosphoSitePlus
T6LMRLHPRD

Dephosphorylation site
BPNT1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000446828*309YCOSMICIntestines Cancer17932254
ENSP00000318852*309YCOSMICIntestines Cancer17932254
ENSP00000318852L8VCOSMICOvarian Cancer21720365
ENSP00000318852Q181*COSMICSkin Cancer21984974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000318852Hepatocellular CarcinomaNormal vs. Cancercell lineDown0.4118646787
ENSP00000318852Breast CancerNormal vs. Cancercell lineUp1.220052998
ENSP00000318852Breast CancerNormal vs. Cancercell lineUp2.920052998
ENSP00000318852Breast CancerMetastasiscell lineUp2.620052998
ENSP00000318852Renal CancerNormal vs. CancertissueUp2.819610612

Hyperphosphorylation site
BPNT1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PKN1_HUMANBPNT1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
BPNT1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0044281small molecule metabolic processTASbiological_process
GO:0004441inositol-1,4-bisphosphate 1-phosphatase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:00084413'(2'),5'-bisphosphate nucleotidase activityIEAmolecular_function
GO:0007399nervous system developmentTASbiological_process
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic prTASbiological_process
GO:0046854phosphatidylinositol phosphorylationIEAbiological_process
GO:0006139nucleobase-containing compound metabolic processTASbiological_process
GO:0006805xenobiotic metabolic processTASbiological_process
GO:0000287magnesium ion bindingIEAmolecular_function


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