| UniProt/SwissProt ID: | BPNT1_HUMAN |
| Description: | 3'(2'), 5'-bisphosphate nucleotidase 1 [Source:HGNC Symbol;Acc:1096] |
| Location: | chr1 q41 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T248 | CKKWDtCAPEV | Inositol_P | PhosphoSitePlus |
| S3 | NTVL | HPRD | |
| S61 | MSICSsLARKF | Inositol_P | PhosphoSitePlus |
| S57 | RLAQMsICSSL | Inositol_P | PhosphoSitePlus |
| Y16 | LVASAySIAQK | Inositol_P | PhosphoSitePlus |
| S240 | AYVFAsPGCKK | Inositol_P | PhosphoSitePlus |
| T6 | MASSNtVLMRL | PhosphoSitePlus | |
| T6 | LMRL | HPRD | |
| Dephosphorylation site |
| BPNT1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000446828 | *309Y | COSMIC | Intestines Cancer | 17932254 | ENSP00000318852 | *309Y | COSMIC | Intestines Cancer | 17932254 | ENSP00000318852 | L8V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000318852 | Q181* | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000318852 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.41 | 18646787 | ENSP00000318852 | Breast Cancer | Normal vs. Cancer | cell line | Up | 1.2 | 20052998 | ENSP00000318852 | Breast Cancer | Normal vs. Cancer | cell line | Up | 2.9 | 20052998 | ENSP00000318852 | Breast Cancer | Metastasis | cell line | Up | 2.6 | 20052998 | ENSP00000318852 | Renal Cancer | Normal vs. Cancer | tissue | Up | 2.8 | 19610612 |
| Hyperphosphorylation site |
| BPNT1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PKN1_HUMAN | BPNT1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| BPNT1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0004441 | inositol-1,4-bisphosphate 1-phosphatase activity | IEA | molecular_function |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0008441 | 3'(2'),5'-bisphosphate nucleotidase activity | IEA | molecular_function |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0050427 | 3'-phosphoadenosine 5'-phosphosulfate metabolic pr | TAS | biological_process |
| GO:0046854 | phosphatidylinositol phosphorylation | IEA | biological_process |
| GO:0006139 | nucleobase-containing compound metabolic process | TAS | biological_process |
| GO:0006805 | xenobiotic metabolic process | TAS | biological_process |
| GO:0000287 | magnesium ion binding | IEA | molecular_function |