| UniProt/SwissProt ID: | OTU7B_HUMAN |
| Description: | OTU domain containing 7B [Source:HGNC Symbol;Acc:16683] |
| Location: | chr1 q21.2 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T371 | EQKENtKEQAV | OTU | PhosphoSitePlus |
| T451 | QPESPtASAGD | PhosphoSitePlus; SysPTM | |
| S464 | RSTPEsGDSDK | PhosphoSitePlus; HPRD; phosphoELM | |
| S103 | GISHAsSSIVS | PhosphoSitePlus | |
| S467 | PESGDsDKESV | PhosphoSitePlus; HPRD; phosphoELM | |
| T65 | SGGSRtPEKGF | PhosphoSitePlus | |
| S149 | NEDFRsFIERD | PhosphoSitePlus | |
| Y779 | SYSNGyREPPE | PhosphoSitePlus | |
| S449 | LAQPEsPTASA | PhosphoSitePlus; HPRD; phosphoELM | |
| S555 | KKKKNsLKSWK | PhosphoSitePlus | |
| S100 | LSRGIsHASSS | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y218 | LRKALyALMEK | OTU | PhosphoSitePlus |
| S159 | DLIEQsMLVAL | PhosphoSitePlus | |
| Dephosphorylation site |
| OTU7B_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000358131 | E833K | COSMIC | Breast Cancer | 20668451 | ENSP00000358131 | E292* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000358131 | P79S | COSMIC | Melanoma | 21499247 |
| Differential expressed protein |
| OTU7B_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| OTU7B_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ACVR1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STK4_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MK01_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PXK_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| STYK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BMR1B_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AURKB_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KPCI_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KAPCB_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| FYN_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| PKN1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MKNK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TESK2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK6_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| KSYK_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK5_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK7_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CDK4_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| GSK3B_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| BTK_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TRIB3_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ACK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| SRPK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| DCLK2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| MP2K6_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CHK2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| RAF1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| IRAK1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| IRAK3_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| CLK2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| WEE1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| TGFR2_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| M3K7_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| AKT1_HUMAN | OTU7B_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| OTU7B_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008234 | cysteine-type peptidase activity | ISS | molecular_function |
| GO:0070536 | protein K63-linked deubiquitination | IDA | biological_process |
| GO:0016579 | protein deubiquitination | IEA | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0071108 | protein K48-linked deubiquitination | ISS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0015630 | microtubule cytoskeleton | IDA | cellular_component |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0035871 | protein K11-linked deubiquitination | IDA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0004221 | ubiquitin thiolesterase activity | IEA | molecular_function |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0002385 | mucosal immune response | ISS | biological_process |
| GO:0006508 | proteolysis | IEA | biological_process |
| GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB c | IDA | biological_process |